Differential Roles of Nuclear and Cytoplasmic Cyclin-Dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death
暂无分享,去创建一个
David S. Park | N. Kushwaha | P. Albert | R. Slack | M. O'hare | I. Vincent | S. Callaghan | H. Aleyasin | Yi Zhang
[1] J C Rothwell,et al. Physiology and Anatomy of Possible Oscillators in the Central Nervous System , 2008, Movement disorders : official journal of the Movement Disorder Society.
[2] J. Massagué,et al. G1 cell-cycle control and cancer , 2004, Nature.
[3] David S. Park,et al. p53 Activation Domain 1 Is Essential for PUMA Upregulation and p53-Mediated Neuronal Cell Death , 2004, The Journal of Neuroscience.
[4] D. Green,et al. The Pathophysiology of Mitochondrial Cell Death , 2004, Science.
[5] I. Kohane,et al. Gene regulation and DNA damage in the ageing human brain , 2004, Nature.
[6] N. Ip,et al. Cdk5: mediator of neuronal death and survival , 2004, Neuroscience Letters.
[7] R. DePinho,et al. Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice , 2003, The Journal of Neuroscience.
[8] David S. Park,et al. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[9] Jerry H. Wang,et al. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors , 2003, Nature Neuroscience.
[10] Lei Zhang,et al. Cyclin-dependent Kinase-5 Is Involved in Neuregulin-dependent Activation of Phosphatidylinositol 3-Kinase and Akt Activity Mediating Neuronal Survival* , 2003, Journal of Biological Chemistry.
[11] David S. Park,et al. Calpains Mediate p53 Activation and Neuronal Death Evoked by DNA Damage* , 2003, Journal of Biological Chemistry.
[12] D. E. Goll,et al. The calpain system. , 2003, Physiological reviews.
[13] S. Zahler,et al. Subcellular Localization and in VivoSubunit Interactions of Ubiquitous μ-Calpain* , 2003, The Journal of Biological Chemistry.
[14] Junmin Peng,et al. Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis , 2003, Neuron.
[15] J. Lupski,et al. Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy , 2002, Nature Genetics.
[16] David S. Park,et al. Interaction of the c-Jun/JNK Pathway and Cyclin-dependent Kinases in Death of Embryonic Cortical Neurons Evoked by DNA Damage* , 2002, The Journal of Biological Chemistry.
[17] David S. Park,et al. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death , 2002, The Journal of cell biology.
[18] Maria K. Lehtinen,et al. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. , 2002, Molecular cell.
[19] A. Kulkarni,et al. Cyclin‐dependent kinase 5 prevents neuronal apoptosis by negative regulation of c‐Jun N‐terminal kinase 3 , 2002, The EMBO journal.
[20] David S. Park,et al. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death , 2001, The Journal of cell biology.
[21] T. Gibson,et al. The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin , 2001, Nature Genetics.
[22] S. Sugano,et al. Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene , 2001, Nature Genetics.
[23] Li-Huei Tsai,et al. A decade of CDK5 , 2001, Nature Reviews Molecular Cell Biology.
[24] David S. Park,et al. Cyclin-Dependent Kinases and P53 Pathways Are Activated Independently and Mediate Bax Activation in Neurons after DNA Damage , 2001, The Journal of Neuroscience.
[25] J. Julien,et al. Deregulation of Cdk5 in a Mouse Model of ALS Toxicity Alleviated by Perikaryal Neurofilament Inclusions , 2001, Neuron.
[26] W. Markesbery,et al. Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. , 2001, Archives of neurology.
[27] H. Soininen,et al. The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis. , 2001, Biochemical and biophysical research communications.
[28] S. Reed,et al. Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle. , 2000, Current opinion in cell biology.
[29] David S. Park,et al. Induction and Modulation of Cerebellar Granule Neuron Death by E2F-1* , 2000, The Journal of Biological Chemistry.
[30] K. Ishiguro,et al. Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25* , 2000, The Journal of Biological Chemistry.
[31] L. Tsai,et al. Neurotoxicity induces cleavage of p35 to p25 by calpain , 2000, Nature.
[32] E. Holmes,et al. Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[33] David S. Park,et al. Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage , 2000, The Journal of Neuroscience.
[34] David S. Park,et al. Involvement of Caspase 3 in Apoptotic Death of Cortical Neurons Evoked by DNA Damage , 2000, Molecular and Cellular Neuroscience.
[35] V Hachinski,et al. Vascular Factors in Cognitive Impairment‐Where Are We Now? , 2000, Annals of the New York Academy of Sciences.
[36] Stephen Lee,et al. Ran-mediated Nuclear Export of the von Hippel-Lindau Tumor Suppressor Protein Occurs Independently of Its Assembly with Cullin-2* , 2000, The Journal of Biological Chemistry.
[37] M. Maki,et al. Caspases cleave the amino-terminal calpain inhibitory unit of calpastatin during apoptosis in human Jurkat T cells. , 2000, Journal of biochemistry.
[38] L. Tsai,et al. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration , 1999, Nature.
[39] F. Nicoletti,et al. Mitotic signaling by β‐amyloid causes neuronal death , 1999 .
[40] R. Maccioni,et al. Inhibition of tau phosphorylating protein kinase cdk5 prevents β‐amyloid‐induced neuronal death , 1999, FEBS letters.
[41] David S. Park,et al. Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis , 1999, The Journal of Neuroscience.
[42] David S. Park,et al. Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons , 1999, The Journal of Neuroscience.
[43] David S. Park,et al. Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death* , 1999, The Journal of Biological Chemistry.
[44] D. Johnson,et al. Cyclins and cell cycle checkpoints. , 1999, Annual review of pharmacology and toxicology.
[45] R. Klausner,et al. Transcription-Dependent Nuclear-Cytoplasmic Trafficking Is Required for the Function of the von Hippel-Lindau Tumor Suppressor Protein , 1999, Molecular and Cellular Biology.
[46] Sten Orrenius,et al. Cleavage of the calpain inhibitor, calpastatin, during apoptosis , 1998, Cell Death and Differentiation.
[47] W. Markesbery,et al. Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease , 1998, Journal of neurochemistry.
[48] David S. Park,et al. Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents , 1998, The Journal of cell biology.
[49] Francesco Cecconi,et al. Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development , 1998, Cell.
[50] L. Tsai,et al. p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway* , 1998, The Journal of Biological Chemistry.
[51] K. Wang,et al. Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis. , 1998, Archives of biochemistry and biophysics.
[52] N. Dyson. The regulation of E2F by pRB-family proteins. , 1998, Genes & development.
[53] P. Schwartzkroin,et al. Bax Involvement in p53-Mediated Neuronal Cell Death , 1998, The Journal of Neuroscience.
[54] David S. Park,et al. Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons , 1997, The Journal of Neuroscience.
[55] C D Marsden,et al. Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra , 1997, Journal of neurochemistry.
[56] R. Simon,et al. Early Detection of DNA Strand Breaks in the Brain After Transient Focal Ischemia: Implications for the Role of DNA Damage in Apoptosis and Neuronal Cell Death , 1997, Journal of neurochemistry.
[57] David S. Park,et al. G1/S Cell Cycle Blockers and Inhibitors of Cyclin-Dependent Kinases Suppress Camptothecin-Induced Neuronal Apoptosis , 1997, The Journal of Neuroscience.
[58] P. D'Arpa,et al. Mechanism of Action of Camptothecin , 1996, Annals of the New York Academy of Sciences.
[59] David S. Park,et al. Induction of CPP32-like Activity in PC12 Cells by Withdrawal of Trophic Support , 1996, The Journal of Biological Chemistry.
[60] P. Schwartzkroin,et al. Evidence for p53-Mediated Modulation of Neuronal Viability , 1996, The Journal of Neuroscience.
[61] Veeranna,et al. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[62] H. M. Geller,et al. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity , 1996, The Journal of cell biology.
[63] Y. Itoyama,et al. DNA single-strand breaks in postischemic gerbil brain detected by in situ nick translation procedure , 1995, Neuroscience Letters.
[64] K. Tomizawa,et al. An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator (*) , 1995, The Journal of Biological Chemistry.
[65] S. Korsmeyer,et al. Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death , 1995, Science.
[66] Utz Fischer,et al. The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs , 1995, Cell.
[67] Q. Lu,et al. Selective nuclear transport of mu-calpain. , 1994, Biochemical and biophysical research communications.
[68] R. Mellgren,et al. m-Calpain requires DNA for activity on nuclear proteins at low calcium concentrations. , 1993, The Journal of biological chemistry.
[69] L. Greene,et al. Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[70] William D. Richardson,et al. A short amino acid sequence able to specify nuclear location , 1984, Cell.
[71] W. Bradley,et al. DNA damage and chronic neuronal degenerations , 1984, Journal of the Neurological Sciences.
[72] S. Zahler,et al. Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain. , 2003, The Journal of biological chemistry.
[73] F. Nicoletti,et al. Mitotic signaling by beta-amyloid causes neuronal death. , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[74] P. Jenner,et al. Oxidative mechanisms in nigral cell death in Parkinson's disease. , 1998, Movement disorders : official journal of the Movement Disorder Society.