Regulation of superficial nephron filtration rate by tubulo-glomerular feedback

SummaryPossible regulation of glomerular filtration rate by tubulo-glomerular feedback from a late tubular site was studied in microperfusion experiments on rats. During perfusion of loops of Henle with varying flow rates and different perfusion solutions, filtration rate of the perfused nephrons was measured by total proximal fluid collection and inulin determination. During perfusion with isotonic Ringer's solution nephron filtration rate decreased significantly with increasing perfusion rates. Since proximal intratubular pressure was experimentally kept constant, this response must reflect decreased glomerular capillary pressure. Increasing the flow rate during perfusion with isotonic sodium sulfate or mannitol solutions was not associated with significant changes of filtration rate. Thus some correlate of the flow rate of normal loop of Henle fluid can affect filtrate formation. Such an effect may be mediated by the juxtaglomerular apparatus. Our results are consistent with the concept that the triggering signal is a function of the amount of distal sodium that is able to permeate the cell membrane at the receptor site rather than of distal intratubular sodium concentration.

[1]  K. Thurau,et al.  Micropuncture studies on the filtration rate of single superficial and juxtamedullary glomeruli in the rat kidney , 2004, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[2]  G. Schloss DER REGULATIONSAPPARAT AM GEFÄSSPOL DES NIERENKÖRPERCHENS IN DER NORMALEN MENSCHLICHEN NIERE , 1945 .

[3]  H. Pagel,et al.  Pressure in the glomerular capillaries of the rat kidney and its relation to arterial blood pressure , 2004, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[4]  C. W. Gottschalk,et al.  Proximal tubular function in rats with low inulin clearance. , 1968, Acta physiologica Scandinavica.

[5]  K. Thurau,et al.  A micropuncture study of the relationship between flow-rate through the loop of Henle and sodium concentration in the early distal tubule , 2004, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[6]  F. Kiil,et al.  Role of autoregulation in maintaining glomerular filtration rate at large urine flow. , 1969, Acta physiologica Scandinavica.

[7]  J. Schnermann,et al.  Balance between tubular flow rate and net fluid reabsorption in the proximal convolution of the rat kidney , 2004, Pflügers Archiv.

[8]  J. Schnermann Microperfusion study of single short loops of Henle in rat kidney , 2004, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[9]  J. Brown,et al.  The effect of acute haemorrhage in the dog and man on plasma‐renin concentration , 1966, The Journal of physiology.

[10]  A. B. Maunsbach,et al.  The juxtaglomerular apparatus as studied electron microscopically. , 1962, Journal of ultrastructure research.

[11]  A. Vander,et al.  CONTROL OF RENIN SECRETION IN THE ANESTHETIZED DOG. , 1964, The American journal of physiology.

[12]  K. Ullrich,et al.  Wasserrückresorption und Ionentransport durch die Sammelrohrzellen der Säugetierniere , 1958, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[13]  A J Vander,et al.  Control of renin release. , 1967, Physiological reviews.

[14]  J. Schnermann,et al.  Die Natriumkonzentration an den Macula densa-Zellen als regulierender Faktor für das Glomerulumfiltrat (Mikropunktionsversuche) , 1965, Klinische Wochenschrift.

[15]  J. Bing,et al.  Renin content of different parts of the juxtaglomerular apparatus. 4. Localization of renin in the kidney. , 2009, Acta pathologica et microbiologica Scandinavica.

[16]  P. Leyssac THE IN VIVO EFFECT OF ANGIOTENSIN ON THE PROXIMAL TUBULAR REABSORPTION OF SALT IN RAT KIDNEYS. , 1964, Acta physiologica Scandinavica.

[17]  J. Schnermann,et al.  Balance between tubular flow rate and net fluid reabsorption in the proximal convolution of the rat kidney , 2004, Pflügers Archiv.

[18]  E. Windhager,et al.  Peritubular control of proximal tubular fluid reabsorption in the rat kidney. , 1968, The American journal of physiology.

[19]  G. Giebisch,et al.  Effect of reduction in filtration rate on renal tubular sodium and water reabsorption. , 1968, The American journal of physiology.

[20]  Cook Wf The detection of renin in juxtaglomerular cells. , 1968 .

[21]  F. S. Wright,et al.  An inhibitory effect of furosemide on sodium reabsorption by the proximal tubule of the rat nephron. , 1969, The Journal of clinical investigation.

[22]  L. Tobian Renin release and its role in renal function and the control of salt balance and arterial pressure. , 1967, Federation proceedings.

[23]  J. Mcmanus Further observations on the glomerular root of the vertebrate kidney. , 1947, The Quarterly journal of microscopical science.

[24]  G. Giebisch,et al.  Effect of ionic substitutions on distal potential differences in rat kidney. , 1966, The American journal of physiology.

[25]  R. C. Nairn,et al.  The histological localization of renin with fluorescent antibody. , 1959, British journal of experimental pathology.

[26]  Y. Kaneko,et al.  Renin release during acute reduction of arterial pressure in normotensive subjects and patients with renovascular hypertension. , 1967, The Journal of clinical investigation.

[27]  K. Thurau RENAL HEMODYNAMICS. , 1964, The American journal of medicine.

[28]  J. Brown,et al.  Influence of sodium deprivation and loading on the plasma‐renin in man , 1964, The Journal of physiology.

[29]  R. Edelman,et al.  Localization of Renin in Juxtaglomerular Cells of Rabbit and Dog Through the Use of the Fluorescent‐Antibody Technique , 1961 .

[30]  J. Führ,et al.  Eine einfache colorimetrische Methode zur Inulinbestimmung für Nieren-Clearance-Untersuchungen bei Stoffwechselgesunden und Diabetikern , 1955, Klinische Wochenschrift.

[31]  D. Levine,et al.  The influence of sampling technique on the micropuncture determination of GFR and reabsorptive characteristics of single rat proximal tubules , 2004, Pflügers Archiv.

[32]  C. W. Gottschalk,et al.  Proximal Tubular Function in Rats with Low Inulin Clearance1 , 1968 .

[33]  H. Iwao,et al.  Control of renin secretion. , 1977, Japanese circulation journal.

[34]  J. Langston,et al.  THEORY FOR RENAL AUTOREGULATION BY FEEDBACK AT THE JUXTAGLOMERULAR APPARATUS. , 1964, Circulation research.

[35]  R. Berliner,et al.  A study by continuous microperfusion of water and electrolyte movements in the loop of Henle and distal tubule of the rat. , 1969, Nephron.

[36]  J. Brown,et al.  The assay of renin in single glomeruli and the appearance of the juxtaglomerular apparatus in the rabbit following renal artery constriction. , 1966, Clinical science.

[37]  K. Gertz,et al.  Transtubuläre Natriumchloridflüsse und Permeabilität für Nichtelektrolyte im proximalen und distalen Konvolut der Rattenniere , 1962, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.