Evaluating motor end‐plate‐targeted injections of botulinum toxin type A in a canine model

Tarsal joint forces were measured in dogs over 70 days following botulinum toxin type A (BTX‐A) injections. Three dogs were injected at motor end‐plates located by electromyography (EMG), while 3 dogs were similarly injected, but without EMG guidance. Extension forces were significantly (P < 0.05) smaller in limbs injected at motor end‐plates than in corresponding limbs on days 14 and 35. There were no significant differences at other times. Using these techniques, EMG end‐plate targeting potentiates effects of BTX‐A. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:653–655, 1998.

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