Nicotine induced autophagy of Leydig cells rather than apoptosis is the major reason of the decrease of serum testosterone.

[1]  Q. Lian,et al.  Nicotine affects rat Leydig cell function in vivo and vitro via down-regulating some key steroidogenic enzyme expressions. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[2]  N. Dochtermann,et al.  Consistent individual variation in day, night, and GnRH-induced testosterone concentrations in house sparrows (Passer domesticus). , 2017, General and comparative endocrinology.

[3]  A. Xiang,et al.  Transplantation of CD51+ Stem Leydig Cells: A New Strategy for the Treatment of Testosterone Deficiency , 2017, Stem cells.

[4]  L. Sarna,et al.  Lung Cancer and Tobacco: What Is New? , 2017, The Nursing clinics of North America.

[5]  K. Cardozo,et al.  Analysis of the functional aspects and seminal plasma proteomic profile of sperm from smokers , 2016, BJU international.

[6]  W. Hellstrom,et al.  Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism , 2016, World journal of stem cells.

[7]  E. Ofori,et al.  Tobacco smoking is associated with decreased semen quality , 2016, Reproductive Health.

[8]  Zhao-xia Wang,et al.  Nicotine induces Nme2-mediated apoptosis in mouse testes. , 2016, Biochemical and biophysical research communications.

[9]  Zhao-xia Wang,et al.  Protein profile screening: reduced expression of Sord in the mouse epididymis induced by nicotine inhibits tyrosine phosphorylation level in capacitated spermatozoa. , 2016, Reproduction.

[10]  Zhao-xia Wang,et al.  Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation1 , 2016, Biology of reproduction.

[11]  Masahiko Watanabe.  Smoking: additional burden on aging and death , 2016, Genes and Environment.

[12]  G. Russo,et al.  TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia , 2016, Cell Death and Disease.

[13]  Jie Cui,et al.  Oncotargets and Therapy Dovepress Expressions and Clinical Significance of Autophagy- Related Markers Beclin1, Lc3, and Egfr in Human Cervical Squamous Cell Carcinoma , 2022 .

[14]  Zhao-xia Wang,et al.  Alteration of sperm protein profile induced by cigarette smoking. , 2015, Acta biochimica et biophysica Sinica.

[15]  Yi-ran Huang,et al.  Testosterone regulates the autophagic clearance of androgen binding protein in rat Sertoli cells , 2015, Scientific Reports.

[16]  Zhao-Ying Liu,et al.  BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells. , 2015, Journal of pharmacological sciences.

[17]  M. Hallek,et al.  AKT-pathway inhibition in chronic lymphocytic leukemia reveals response relationships defined by TCL1. , 2014, Current cancer drug targets.

[18]  M. Noguchi,et al.  Inhibition of Akt kinase activity suppresses entry and replication of influenza virus. , 2014, Biochemical and biophysical research communications.

[19]  S. M. Miraglia,et al.  Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue , 2014, Andrology.

[20]  S. Shankar,et al.  Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. , 2014, Cancer letters.

[21]  P. Panda,et al.  Autophagy and apoptosis: where do they meet? , 2014, Apoptosis.

[22]  Zhao-xia Wang,et al.  Cigarette Smoking Exposure Alters Pebp1 DNA Methylation and Protein Profile Involved in MAPK Signaling Pathway in Mice Testis1 , 2013, Biology of reproduction.

[23]  Liankun Sun,et al.  Suppression of Chloride Channel 3 Expression Facilitates Sensitivity of Human Glioma U251 Cells to Cisplatin Through Concomitant Inhibition of Akt and Autophagy , 2013, Anatomical record.

[24]  Zhao-xia Wang,et al.  The alteration of protein profile induced by cigarette smoking via oxidative stress in mice epididymis. , 2013, The international journal of biochemistry & cell biology.

[25]  I. Oyeyipo,et al.  Nicotine alters male reproductive hormones in male albino rats: The role of cessation , 2013, Journal of human reproductive sciences.

[26]  Qing Wu,et al.  Neonatal exposure to benzo[a]pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats. , 2012, Toxicology.

[27]  S. Shankar,et al.  Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. , 2012, Biochemical pharmacology.

[28]  Zuo-min Zhou,et al.  Autophagy and Apoptosis Act as Partners to Induce Germ Cell Death after Heat Stress in Mice , 2012, PloS one.

[29]  S. Hsia,et al.  The endocrine effects of nicotine and cigarette smoke , 2012, Trends in Endocrinology & Metabolism.

[30]  Gang Li,et al.  Expression of proliferin-related protein in testis and the biological significance in testosterone production , 2011, Molecular and Cellular Endocrinology.

[31]  J. A. Dani,et al.  Reward, addiction, withdrawal to nicotine. , 2011, Annual review of neuroscience.

[32]  Zheng Zhou,et al.  [P70S6K is involved in the inhibition of testosterone production in TM3 mouse Leydig cells overexpressing Cox7a2]. , 2011, Zhonghua nan ke xue = National journal of andrology.

[33]  S. Hamamah,et al.  Effects of cigarette smoking on reproduction. , 2011, Human reproduction update.

[34]  F. Cecconi,et al.  The Role of Autophagy During Development in Higher Eukaryotes , 2010, Traffic.

[35]  D. Klionsky,et al.  Eaten alive: a history of macroautophagy , 2010, Nature Cell Biology.

[36]  P. K. Samanta,et al.  Nicotine diminishes testicular gametogenesis, steroidogenesis, and steroidogenic acute regulatory protein expression in adult albino rats: possible influence on pituitary gonadotropins and alteration of testicular antioxidant status. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[37]  B. Kramer,et al.  American Society of Clinical Oncology policy statement: the role of the oncologist in cancer prevention and risk assessment. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[38]  A. C. Collins,et al.  Guidelines on nicotine dose selection for in vivo research , 2007, Psychopharmacology.

[39]  B. Oh,et al.  Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG , 2006, Nature Cell Biology.

[40]  I. Huhtaniemi,et al.  Testicular cell lines , 2004, Molecular and Cellular Endocrinology.

[41]  A. Niemann,et al.  Fluorescence Properties and Staining Behavior of Monodansylpentane, a Structural Homologue of the Lysosomotropic Agent Monodansylcadaverine , 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.