A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes,oct-3 is expressed in the totipotent and pluripotent stem cells of the pre-gastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.

[1]  A. McMahon,et al.  Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo , 1987, Cell.

[2]  G. Martin,et al.  Teratocarcinomas as a model system for the study of embryogenesis and neoplasia , 1975, Cell.

[3]  L. Staudt,et al.  A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain , 1988, Cell.

[4]  L. C. Stevens,et al.  The development of teratomas from parthenogenetically activated ovarian mouse eggs. , 1974, Developmental biology.

[5]  H. Schöler,et al.  A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes , 1987, Nature.

[6]  H. Blau,et al.  Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed , 1983, Molecular and cellular biology.

[7]  R. Roeder,et al.  A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein , 1988, Nature.

[8]  W. Schaffner,et al.  Cell type‐specificity elements of the immunoglobulin heavy chain gene enhancer. , 1987, The EMBO journal.

[9]  H. Schöler,et al.  A family of octamer‐specific proteins present during mouse embryogenesis: evidence for germline‐specific expression of an Oct factor. , 1989, The EMBO journal.

[10]  Carl Wu,et al.  Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis , 1987, Nature.

[11]  M. Kaufman,et al.  Establishment in culture of pluripotential cells from mouse embryos , 1981, Nature.

[12]  P. Donovan,et al.  Migratory and postmigratory mouse primordial germ cells behave differently in culture , 1986, Cell.

[13]  L. Staudt,et al.  Repression of the IgH enhancer in teratocarcinoma cells associated with a novel octamer factor. , 1989, Science.

[14]  W. Herr,et al.  The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. , 1988, Genes & development.

[15]  S. Strickland,et al.  The induction of differentiation in teratocarcinoma stem cells by retinoic acid , 1978, Cell.

[16]  N. Heintz,et al.  Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene , 1987, Cell.

[17]  Hans R. Schöler,et al.  New type of POU domain in germ line-specific protein Oct-4 , 1990, Nature.

[18]  P. Tucker,et al.  Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences , 1986, Nature.

[19]  F. Sanger,et al.  DNA sequencing with chain-terminating inhibitors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[20]  W. Herr,et al.  A 100-kD HeLa cell octamer binding protein (OBP100) interacts differently with two separate octamer-related sequences within the SV40 enhancer. , 1987, Genes & development.

[21]  P. Sharp,et al.  Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro. , 1988, Genes & development.

[22]  E. A. O'neill,et al.  The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain , 1989, Cell.

[23]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[24]  P. Sharp,et al.  The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains. , 1988, Genes & development.

[25]  P. Sharp,et al.  Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif. , 1988, Science.

[26]  W. Schaffner,et al.  A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells , 1988, Nature.

[27]  G. Martin,et al.  Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[28]  D. Belin,et al.  Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNA. , 1987, Genes & development.

[29]  H. Schöler,et al.  Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. , 1989, The EMBO journal.

[30]  R. Roeder,et al.  Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[31]  S. Rusconi,et al.  Metal binding ‘finger’ structures in the glucocorticoid receptor defined by site‐directed mutagenesis. , 1988, The EMBO journal.

[32]  K. Okamoto,et al.  A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells , 1990, Cell.

[33]  Marek Mlodzik,et al.  Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis , 1987, Cell.

[34]  G. Ruvkun,et al.  The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. , 1988, Genes & development.

[35]  B. Hoffman,et al.  A simple and very efficient method for generating cDNA libraries. , 1983, Gene.

[36]  R. Burgess,et al.  Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes. , 1980, Analytical biochemistry.

[37]  P. Holland,et al.  Expression of homeo box genes during mouse development: a review. , 1988, Genes & development.

[38]  P. Sharp,et al.  A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes , 1986, Nature.

[39]  A. Heguy,et al.  Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro , 1987, Cell.

[40]  P. Sharp,et al.  A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes , 1986, Nature.

[41]  M. McBurney,et al.  Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line , 1982, Nature.

[42]  A. Bradley,et al.  Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector , 1986, Nature.