Evidence for a social function of the anterior temporal lobes: Low-frequency rTMS reduces implicit gender stereotypes

By nature, stereotypes require processes of categorization or semantic association, including social information about groups of people. There is empirical evidence that the anterior temporal lobe (ATL) processes domain‐general semantic information, and supports social knowledge. A recent study showed that inhibitory repetitive transcranial magnetic stimulation (rTMS) to the ATL reduced racial stereotypes on an implicit association test (IAT). However, it was not determined whether this was caused by changes to specific social, or general semantic processing, or both. The current study addresses these theoretical issues. The design investigated the effect of rTMS to the left or right ATL, or a sham stimulation, on a social IAT (gender stereotypes), a non-social IAT (living versus non-living associations), and a non-semantic control (Stroop) task. The results showed that low-frequency rTMS to both left and right ATL significantly reduced D-scores on the gender IAT compared to the sham group; however, there were no differences on the non-social IAT or the Stroop. The findings show the ATL has a role in mediating stereotypes, and the decrease of bias after stimulation could be due to weakening of social stereotypical associations either within the ATL or via a network of brain regions connected with the ATL.

[1]  R. Myers,et al.  Neural control of social behavior: prefrontal and anterior temporal cortex. , 1973, Neuropsychologia.

[2]  Jordan Grafman,et al.  Social concepts are represented in the superior anterior temporal cortex , 2007, Proceedings of the National Academy of Sciences.

[3]  Ingrid R. Olson,et al.  Social cognition and the anterior temporal lobes , 2010, NeuroImage.

[4]  S. Fiske.  Social Cognition and the Normality of Prejudgment , 2008 .

[5]  J Tudor-Hart,et al.  On the nature of prejudice. , 1961, The Eugenics review.

[6]  P. Devine.  Stereotypes and prejudice: Their automatic and controlled components. , 1989 .

[7]  L. Squire,et al.  The medial temporal lobe memory system , 1991, Science.

[8]  Richard S. J. Frackowiak,et al.  A voxel‐based morphometry study of semantic dementia: Relationship between temporal lobe atrophy and semantic memory , 2000, Annals of neurology.

[9]  P. Devine,et al.  Stereotyping and evaluation in implicit race bias: evidence for independent constructs and unique effects on behavior. , 2006, Journal of personality and social psychology.

[10]  G. Gainotti.  Different patterns of famous people recognition disorders in patients with right and left anterior temporal lesions: A systematic review , 2007, Neuropsychologia.

[11]  R. Kikinis,et al.  Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study. , 2002, The American journal of psychiatry.

[12]  M. A. Lambon Ralph,et al.  The inferior, anterior temporal lobes and semantic memory clarified: Novel evidence from distortion-corrected fMRI , 2010, Neuropsychologia.

[13]  R. Goebel,et al.  Individual faces elicit distinct response patterns in human anterior temporal cortex , 2007, Proceedings of the National Academy of Sciences.

[14]  M. L. Lambon Ralph,et al.  The role of the anterior temporal lobes in the comprehension of concrete and abstract words: rTMS evidence , 2009, Cortex.

[15]  Brian A. Nosek,et al.  Understanding and Using the Implicit Association Test: II. Method Variables and Construct Validity , 2005, Personality & social psychology bulletin.

[16]  A. Greenwald,et al.  Measuring individual differences in implicit cognition: the implicit association test. , 1998, Journal of personality and social psychology.

[17]  M. L. Lambon Ralph,et al.  Conceptual knowledge is underpinned by the temporal pole bilaterally: convergent evidence from rTMS. , 2009, Cerebral cortex.

[18]  C. Price,et al.  Identification of famous faces and buildings: a functional neuroimaging study of semantically unique items. , 2001, Brain : a journal of neurology.

[19]  J. Hilton,et al.  Attitudes and the Implicit Association Test. , 2001, Journal of personality and social psychology.

[20]  L. Brothers,et al.  The neural basis of primate social communication , 1990 .

[21]  Lars A. Ross,et al.  Improved proper name recall by electrical stimulation of the anterior temporal lobes , 2010, Neuropsychologia.

[22]  C. Frith.  The social brain? , 2007, Philosophical Transactions of the Royal Society B: Biological Sciences.

[23]  N. Birbaumer,et al.  Enhancement of Planning Ability by Transcranial Direct Current Stimulation , 2009, The Journal of Neuroscience.

[24]  Á. Pascual-Leone,et al.  Noninvasive human brain stimulation. , 2007, Annual review of biomedical engineering.

[25]  E. Wassermann,et al.  A safety screening questionnaire for transcranial magnetic stimulation , 2001, Clinical Neurophysiology.

[26]  Brian A. Nosek,et al.  Understanding and using the implicit association test: I. An improved scoring algorithm. , 2003, Journal of personality and social psychology.

[27]  Jordan Grafman,et al.  Social conceptual impairments in frontotemporal lobar degeneration with right anterior temporal hypometabolism. , 2009, Brain : a journal of neurology.

[28]  Mahzarin R. Banaji,et al.  The Neural Basis of Implicit Attitudes , 2008 .

[29]  James L. McClelland,et al.  Structure and deterioration of semantic memory: a neuropsychological and computational investigation. , 2004, Psychological review.

[30]  Allan Snyder,et al.  Noninvasive brain stimulation reduces prejudice scores on an implicit association test. , 2011, Neuropsychology.

[31]  Jim E. H. Bright,et al.  Cognition with and without awareness , 1996 .

[32]  R. N. Spreng,et al.  I remember you: A role for memory in social cognition and the functional neuroanatomy of their interaction , 2012, Brain Research.

[33]  T. Rogers,et al.  Where do you know what you know? The representation of semantic knowledge in the human brain , 2007, Nature Reviews Neuroscience.

[34]  Edward E. Smith,et al.  Concepts and concept formation. , 1984, Annual review of psychology.

[35]  Richard J. Binney,et al.  The ventral and inferolateral aspects of the anterior temporal lobe are crucial in semantic memory: evidence from a novel direct comparison of distortion-corrected fMRI, rTMS, and semantic dementia. , 2010, Cerebral cortex.

[36]  Gerald L. Russell,et al.  The temporal variant of frontotemporal dementia. , 1997, Brain : a journal of neurology.

[37]  Shigeru Sato,et al.  Comprehension of implicit meanings in social situations involving irony: A functional MRI study , 2007, NeuroImage.

[38]  J. Dovidio,et al.  Introduction: Reflecting on The Nature of Prejudice: Fifty Years after Allport , 2008 .

[39]  Jean-Francois Mangin,et al.  Modulation of language areas with functional MR image-guided magnetic stimulation , 2006, NeuroImage.

[40]  Yoko Mano,et al.  Dissociable Roles of the Anterior Temporal Regions in Successful Encoding of Memory for Person Identity Information , 2010, Journal of Cognitive Neuroscience.

[41]  W. K. Simmons,et al.  The Selectivity and Functional Connectivity of the Anterior Temporal Lobes , 2009, Cerebral cortex.

[42]  Cara L. Wong,et al.  Low-frequency repetitive transcranial magnetic stimulation of the anterior temporal lobes does not dissociate social versus nonsocial semantic knowledge , 2011, Quarterly journal of experimental psychology.

[43]  J. Rothwell,et al.  Transcranial magnetic stimulation in cognitive neuroscience – virtual lesion, chronometry, and functional connectivity , 2000, Current Opinion in Neurobiology.

[44]  Uwe Herwig,et al.  Using the International 10-20 EEG System for Positioning of Transcranial Magnetic Stimulation , 2004, Brain Topography.

[45]  Felipe Fregni,et al.  Visual memory improved by non-invasive brain stimulation , 2010, Brain Research.

[46]  Edward M. Bowden,et al.  Neural Activity When People Solve Verbal Problems with Insight , 2004, PLoS biology.

[47]  Hj Norussis,et al.  SPSS for Windows , 1993 .

[48]  C. Wilson,et al.  Functional connections in the human temporal lobe , 1990, Experimental Brain Research.

[49]  Alan C. Evans,et al.  Transcranial Magnetic Stimulation during Positron Emission Tomography: A New Method for Studying Connectivity of the Human Cerebral Cortex , 1997, The Journal of Neuroscience.

[50]  Alvaro Pascual-Leone,et al.  Transcranial Magnetic Stimulation in Child Neurology: Current and Future Directions , 2008, Journal of child neurology.

[51]  Christopher C. Pack,et al.  Improved Discrimination of Visual Stimuli Following Repetitive Transcranial Magnetic Stimulation , 2010, PloS one.

[52]  I. Olson,et al.  The Enigmatic temporal pole: a review of findings on social and emotional processing. , 2007, Brain : a journal of neurology.

[53]  W. K. Simmons,et al.  The anterior temporal lobes and the functional architecture of semantic memory , 2009, Journal of the International Neuropsychological Society.

[54]  Allan Snyder,et al.  Reducing false memories by magnetic pulse stimulation , 2009, Neuroscience Letters.