Sinus Node Function in Children: Factors Influencing its Evaluation

Overdrive atrial stimulation was performed in 20 electrophysiologically normal children at the time of routine diagnostic cardiac catheterization, for the determination of the sinus node recovery time (SNRT). Measurements were made at pacing rates of 120, 150, 180, and 200 beats/min.The absolute recovery times demonstrated a wide range of values (420–1280 msec). Expressed as a percent of the resting P-P interval, values at pacing rates of 120 and 150 beats/min were 109–166%, with significantly less overdrive suppression (P < 0.001) occurring at the two faster pacing rates. Atropine diminished the maximum SNRT in all patients tested. This study reports normal values for the SNRT in children. Factors which influence the SNRT are the resting heart rate, the rate of overdrive, and the autonomic tone. In children, the sinus node recovery time should be expressed in terms of the resting sinus interval

[1]  R. Helfant,et al.  Corrected sinus node recovery time. Experimental physiologic and pathologic determinants. , 1975, Circulation.

[2]  E. Lichstein,et al.  Appraisal of sinus nodal recovery time in patients with sick sinus syndrome. , 1974, The American journal of cardiology.

[3]  P. Gillette,et al.  THE RESPONSE OF THE SINO-ATRIAL NODE TO RAPID ATRIAL STIMULATION , 1974, Pediatric Research.

[4]  J. Spear,et al.  Influence of Brief Vagal and Stellate Nerve Stimulation on Pacemaker Activity and Conduction within the Atrioventricular Conduction System of the Dog , 1973, Circulation research.

[5]  J. Bigger,et al.  Premature Atrial Stimulation as a Key to the Understanding of Sinoatrial Conduction in Man: Presentation of Data and Critical Review of the Literature , 1973, Circulation.

[6]  W. Mandel,et al.  Assessment of Sinus Node Function in Patients with the Sick Sinus Syndrome , 1972, Circulation.

[7]  P. Samet,et al.  Significance of the Sinus‐Node Recovery Time , 1972, Circulation.

[8]  H S Marcus,et al.  Evaluation of Sino‐atrial Node Function in Man by Overdrive Suppression , 1971, Circulation.

[9]  S. Goldberg,et al.  The effects of meperidine, promethazine, and chlorpromazine on pulmonary and systemic circulation , 1969 .

[10]  Daniel A. Brody,et al.  Application of Computer Techniques to the Detection and Analysis of Spontaneous P‐Wave Variations , 1967, Circulation.

[11]  T. K. Marshall,et al.  Sudden Death in Young Athletes. , 1967 .

[12]  G. Lange.  Action of Driving Stimuli from Intrinsic and Extrinsic Sources on in Situ Cardiac Pacemaker Tissues , 1965, Circulation research.

[13]  G. Lange,et al.  Factors Controlling Pacemaker Action in Cells of the Sinoatrial Node , 1965, Circulation research.

[14]  T. C. West,et al.  RELEASE OF AUTONOMIC MEDIATORS IN CARDIAC TISSUE BY DIRECT SUBTHRESHOLD ELECTRICAL STIMULATION. , 1963, The Journal of pharmacology and experimental therapeutics.

[15]  A. C. Young,et al.  The Mechanism of Atrioventricular Conduction , 1959, Circulation research.

[16]  W. H. Gaskell.  On the Innervation of the Heart, with especial reference to the Heart of the Tortoise , 1883, The Journal of physiology.

[17]  E. Clark,et al.  Should the sinus venosus type ASD be closed? A review of the atrial conduction defects and surgical results in twenty eight children , 1975 .

[18]  R. Rowe,et al.  “Sluggish” sinus node syndrome as a part of congenital heart disease , 1974 .