论文信息 - Designing Chemical Libraries for Lead Discovery

Designing Chemical Libraries for Lead Discovery

The selection of compounds for use in high throughput biological assays is one of the critical factors that dictates the likelihood of detecting exploitable biological properties. In this paper, we present a process designed to deliver molecules that contain chemical functionality of immediate value in a lead discovery program, molecules that are sufficiently different from each other to ensure that redundancy of effort is avoided. The design process has already been implemented and used to add tens of thousands of reaction products to the Optiverse™ library

D. E. Patterson | A. M. Ferguson | T. Underiner | C. Garr

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