Acute ischemic stroke trials.

To the Editor: We congratulate Duncan and colleagues on their illuminating report regarding outcome measures in acute stroke trials.1 However, we wish to point out that their claim to have analyzed all “phase II and phase III randomized trials of pharmacological interventions in the acute phase of stroke, published in English in 1980 or later” may be overstated. They review only 51 trials. Our systematic review of all randomized acute ischemic stroke trials reported in English has …