Combinatorial drug therapy for cancer in the post-genomic era
暂无分享,去创建一个
[1] T. Yap,et al. Development of therapeutic combinations targeting major cancer signaling pathways. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] Christie S. Chang,et al. The BioGRID interaction database: 2013 update , 2012, Nucleic Acids Res..
[3] A. Jemal,et al. Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. , 2012, The Lancet. Oncology.
[4] Qian Wang,et al. Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[5] Mallika Singh,et al. Genetically engineered mouse models: closing the gap between preclinical data and trial outcomes. , 2012, Cancer research.
[6] Sven Diederichs,et al. The hallmarks of cancer , 2012, RNA biology.
[7] H. Brody. From an ethics of rationing to an ethics of waste avoidance. , 2012, The New England journal of medicine.
[8] P. Sorger,et al. Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks , 2012, Cell.
[9] Paul Workman,et al. Personalized medicine: patient-predictive panel power. , 2012, Cancer cell.
[10] Andrew L. Kung,et al. Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. , 2012, Cancer cell.
[11] Jian Jin,et al. Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer , 2012, Cell.
[12] D. Berry. Adaptive clinical trials in oncology , 2012, Nature Reviews Clinical Oncology.
[13] Charles Swanton,et al. Intratumor Heterogeneity: Seeing the Wood for the Trees , 2012, Science Translational Medicine.
[14] D. Solit,et al. Will Hsp90 Inhibitors Prove Effective in BRAF-Mutant Melanomas? , 2012, Clinical Cancer Research.
[15] S. Lowe,et al. Life in the Fast Lane: Mammalian Disease Models in the Genomics Era , 2012, Cell.
[16] Hugo Y. K. Lam,et al. Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes , 2012, Cell.
[17] Ben H. Park,et al. Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood , 2012, Clinical Cancer Research.
[18] S. Ramaswamy,et al. Systematic identification of genomic markers of drug sensitivity in cancer cells , 2012, Nature.
[19] P. A. Futreal,et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. , 2012, The New England journal of medicine.
[20] Adam A. Margolin,et al. The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.
[21] P. Workman,et al. Discovery of small molecule cancer drugs: Successes, challenges and opportunities , 2012, Molecular oncology.
[22] Levi A Garraway,et al. Circumventing cancer drug resistance in the era of personalized medicine. , 2012, Cancer discovery.
[23] M. Piccart,et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. , 2012, The New England journal of medicine.
[24] Michele De Palma,et al. The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilities , 2012, Molecular oncology.
[25] B. Taylor,et al. Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring V600EBRAF , 2012, Oncogene.
[26] R. Bernards,et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR , 2012, Nature.
[27] P. Workman,et al. Exploiting the cancer genome: strategies for the discovery and clinical development of targeted molecular therapeutics. , 2012, Annual review of pharmacology and toxicology.
[28] E. Baudin,et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[29] Paul Workman,et al. Hsp90 Molecular Chaperone Inhibitors: Are We There Yet? , 2012, Clinical Cancer Research.
[30] Xing-Ming Zhao,et al. Prediction of Drug Combinations by Integrating Molecular and Pharmacological Data , 2011, PLoS Comput. Biol..
[31] Tom Misteli,et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) , 2011, Nature.
[32] Bissan Al-Lazikani,et al. canSAR: an integrated cancer public translational research and drug discovery resource , 2011, Nucleic Acids Res..
[33] W. Pao,et al. Evolutionary Modeling of Combination Treatment Strategies To Overcome Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer , 2011, Molecular pharmaceutics.
[34] W. Sellers. A Blueprint for Advancing Genetics-Based Cancer Therapy , 2011, Cell.
[35] Lincoln Stein,et al. Reactome pathway analysis to enrich biological discovery in proteomics data sets , 2011, Proteomics.
[36] F. Prinz,et al. Believe it or not: how much can we rely on published data on potential drug targets? , 2011, Nature Reviews Drug Discovery.
[37] Sarat Chandarlapaty,et al. mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling. , 2011, Cancer discovery.
[38] Tom L. Blundell,et al. Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database , 2011, BMC Bioinformatics.
[39] N. Socci,et al. Optimization of Dosing for EGFR-Mutant Non–Small Cell Lung Cancer with Evolutionary Cancer Modeling , 2011, Science Translational Medicine.
[40] A. Hauschild,et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. , 2011, The New England journal of medicine.
[41] E. Ruppin,et al. Predicting selective drug targets in cancer through metabolic networks , 2011, Molecular systems biology.
[42] K. Flaherty,et al. Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436). , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[43] P. Workman,et al. Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors , 2011, Current medicinal chemistry.
[44] Arturo Molina,et al. Abiraterone and increased survival in metastatic prostate cancer. , 2011, The New England journal of medicine.
[45] A. Tolcher,et al. A phase I dose-escalation study of oral MK-2206 (allosteric AKT inhibitor) with oral selumetinib (AZD6244; MEK inhibitor) in patients with advanced or metastatic solid tumors. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[46] Luay Nakhleh,et al. Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling , 2011, Oncogene.
[47] M. Garrett,et al. Anticancer therapy with checkpoint inhibitors: what, where and when? , 2011, Trends in pharmacological sciences.
[48] J. Troge,et al. Tumour evolution inferred by single-cell sequencing , 2011, Nature.
[49] Sanjay A Pai,et al. The emperor of all maladies , 2011 .
[50] J. Woodcock,et al. Development of novel combination therapies. , 2011, The New England journal of medicine.
[51] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[52] Julio Saez-Rodriguez,et al. Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli , 2011, PLoS Comput. Biol..
[53] K. Anderson,et al. Genetic variegation of clonal architecture and propagating cells in leukaemia , 2011, Nature.
[54] C. Der. Faculty Opinions recommendation of COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. , 2010 .
[55] L. Garraway,et al. Clinical implications of the cancer genome. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[56] Michael Peyton,et al. Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo , 2010, PloS one.
[57] Paul N. Mortenson,et al. Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. , 2010, Journal of medicinal chemistry.
[58] Gary D. Bader,et al. Pathway Commons, a web resource for biological pathway data , 2010, Nucleic Acids Res..
[59] Lincoln Stein,et al. Reactome: a database of reactions, pathways and biological processes , 2010, Nucleic Acids Res..
[60] Damian Szklarczyk,et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored , 2010, Nucleic Acids Res..
[61] Jeffrey W. Clark,et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. , 2010, The New England journal of medicine.
[62] V. A. Shiva Ayyadurai,et al. CytoSolve: A Scalable Computational Method for Dynamic Integration of Multiple Molecular Pathway Models , 2010, Cellular and molecular bioengineering.
[63] Alan Ashworth,et al. Translating cancer research into targeted therapeutics , 2010, Nature.
[64] M. Gerlinger,et al. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine , 2010, British Journal of Cancer.
[65] Yiling Lu,et al. Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis. , 2010, Cancer research.
[66] D. Schadendorf,et al. Improved survival with ipilimumab in patients with metastatic melanoma. , 2010, The New England journal of medicine.
[67] Taebo Sim,et al. A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl. , 2010, Journal of medicinal chemistry.
[68] Paul Workman,et al. Envisioning the future of early anticancer drug development , 2010, Nature Reviews Cancer.
[69] G. Hon,et al. Next-generation genomics: an integrative approach , 2010, Nature Reviews Genetics.
[70] G. Shapiro,et al. A Phase I Study of Foretinib, a Multi-Targeted Inhibitor of c-Met and Vascular Endothelial Growth Factor Receptor 2 , 2010, Clinical Cancer Research.
[71] Melanie I. Stefan,et al. BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models , 2010, BMC Systems Biology.
[72] Borisas Bursteinas,et al. ROCK: a breast cancer functional genomics resource , 2010, Breast Cancer Research and Treatment.
[73] Mallika Singh,et al. Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models , 2010, Nature Biotechnology.
[74] A. Balmain,et al. Guidelines for the welfare and use of animals in cancer research , 2010, British Journal of Cancer.
[75] C. Ng,et al. A phase I study of bevacizumab in combination with sunitinib, sorafenib, and erlotinib plus cetuximab, and trastuzumab plus lapatinib. , 2010 .
[76] J. Baselga,et al. A phase I study of the oral mTOR inhibitor ridaforolimus (RIDA) in combination with the IGF-1R antibody dalotozumab (DALO) in patients (pts) with advanced solid tumors. , 2010 .
[77] Bo Zhang,et al. A formal model for analyzing drug combination effects and its application in TNF-α-induced NFκB pathway , 2010, BMC Systems Biology.
[78] J. Humm,et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study , 2010, The Lancet.
[79] Mark P Little,et al. Cancer models, genomic instability and somatic cellular Darwinian evolution , 2010, Biology Direct.
[80] Ben S. Wittner,et al. A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations , 2010, Cell.
[81] F. Michor,et al. Evolution of resistance to anti-cancer therapy during general dosing schedules. , 2010, Journal of theoretical biology.
[82] Chao Zhang,et al. RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF , 2010, Nature.
[83] Jacob J Hughey,et al. Computational modeling of mammalian signaling networks , 2010, Wiley interdisciplinary reviews. Systems biology and medicine.
[84] T. Mukohara,et al. Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.
[85] Martin Peifer,et al. Analysis of Compound Synergy in High-Throughput Cellular Screens by Population-Based Lifetime Modeling , 2010, PloS one.
[86] J. Reis-Filho,et al. Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF , 2010, Cell.
[87] Gary D Bader,et al. The Genetic Landscape of a Cell , 2010, Science.
[88] S. Martino,et al. Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: a phase 3, open-label, randomised controlled trial , 2009, The Lancet.
[89] R. Bernards,et al. Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer , 2009, Oncogene.
[90] A. Ashworth,et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.
[91] T. Mok,et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. , 2009, The New England journal of medicine.
[92] Livia Perfetto,et al. MINT, the molecular interaction database: 2009 update , 2009, Nucleic Acids Res..
[93] Li Wang,et al. High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886) , 2009, Cancer biology & therapy.
[94] S. Chandarlapaty,et al. Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth , 2009, Oncogene.
[95] Irina M. Armean,et al. The IntAct molecular interaction database in 2010 , 2009, Nucleic Acids Res..
[96] P. R. ten Wolde,et al. Spatio-temporal correlations can drastically change the response of a MAPK pathway , 2009, Proceedings of the National Academy of Sciences.
[97] T. Willson,et al. Open access chemical and clinical probes to support drug discovery. , 2009, Nature chemical biology.
[98] Michael J. Emanuele,et al. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene , 2009, Cell.
[99] G. Vassal,et al. Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells. , 2009, Cancer research.
[100] U. Banerji,et al. Heat Shock Protein 90 as a Drug Target: Some Like It Hot , 2009, Clinical Cancer Research.
[101] Ralph Weissleder,et al. Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers , 2008, Nature Medicine.
[102] Corey Nislow,et al. Combination chemical genetics. , 2008, Nature chemical biology.
[103] K. Shokat,et al. Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases , 2008, Nature chemical biology.
[104] M. Esteller,et al. Epigenetic biomarkers for human cancer: the time is now. , 2008, Critical reviews in oncology/hematology.
[105] M. Stratton,et al. Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing , 2008, Proceedings of the National Academy of Sciences.
[106] W. Scheithauer,et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[107] L. Pearl,et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. , 2008, Cancer research.
[108] L. Pearl,et al. The Hsp90 molecular chaperone: an open and shut case for treatment. , 2008, The Biochemical journal.
[109] M. Meyerson,et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP , 2008, Proceedings of the National Academy of Sciences.
[110] A. Ashworth,et al. Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer. , 2008, Cancer cell.
[111] C. Keith,et al. The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action. , 2007, Cancer research.
[112] C. Hudis,et al. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[113] G. Mills,et al. Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling , 2011 .
[114] Forest M White,et al. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma , 2007, Proceedings of the National Academy of Sciences.
[115] A. Ashworth,et al. Utilizing RNA interference to enhance cancer drug discovery , 2007, Nature Reviews Drug Discovery.
[116] Pall I. Olason,et al. A human phenome-interactome network of protein complexes implicated in genetic disorders , 2007, Nature Biotechnology.
[117] P. Lønning,et al. Survival and safety of exemestane versus tamoxifen after 2–3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial , 2007, The Lancet.
[118] Apurva A Desai,et al. Sorafenib in advanced clear-cell renal-cell carcinoma. , 2007, The New England journal of medicine.
[119] K. Shokat,et al. Escape from HER family tyrosine kinase inhibitor therapy by the kinase inactive HER3 , 2007, Nature.
[120] M. Berger,et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. , 2006, The New England journal of medicine.
[121] Madhusudan Natarajan,et al. A global analysis of cross-talk in a mammalian cellular signalling network , 2006, Nature Cell Biology.
[122] Y. Bang,et al. Histone Deacetylase Inhibitors for Cancer Therapy , 2006, Epigenetics.
[123] K. Sachs,et al. Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data , 2005, Science.
[124] M. Kris,et al. Pulsatile Administration of the Epidermal Growth Factor Receptor Inhibitor Gefitinib Is Significantly More Effective than Continuous Dosing for Sensitizing Tumors to Paclitaxel , 2005, Clinical Cancer Research.
[125] P. Workman,et al. The combination of cytotoxic and molecularly targeted therapies - can it be done? , 2004 .
[126] Michael E Phelps,et al. Systems Biology and New Technologies Enable Predictive and Preventative Medicine , 2004, Science.
[127] T. Hunter,et al. Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies , 2004, Current Biology.
[128] Armando Santoro,et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. , 2004, The New England journal of medicine.
[129] Michael S Saag,et al. Treatment for Adult HIV Infection 2006 Recommendations of the International AIDS Society–USA Panel , 2006 .
[130] J. Kornhauser,et al. PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation , 2004, Proteomics.
[131] M. Hung,et al. The HER-2-Targeting Antibodies Trastuzumab and Pertuzumab Synergistically Inhibit the Survival of Breast Cancer Cells , 2004, Cancer Research.
[132] Ming Tan,et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. , 2004, Cancer cell.
[133] T. Hubbard,et al. A census of human cancer genes , 2004, Nature Reviews Cancer.
[134] Michael I. Jordan,et al. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[135] D. Wodarz,et al. Evolutionary dynamics of mutator phenotypes in cancer: implications for chemotherapy. , 2003, Cancer research.
[136] J. Kuriyan,et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. , 2002, Cancer cell.
[137] I. Weinstein. Addiction to Oncogenes--the Achilles Heal of Cancer , 2002, Science.
[138] J. Cuzick,et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial , 2002, The Lancet.
[139] Gabriele Ausiello,et al. MINT: the Molecular INTeraction database , 2006, Nucleic Acids Res..
[140] B. E. C. Oiffier,et al. CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma , 2002 .
[141] R. Wooster,et al. Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential. , 2001, Biochemical pharmacology.
[142] C. Sawyers,et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. , 2001, The New England journal of medicine.
[143] D. Tuveson,et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. , 2001, The New England journal of medicine.
[144] Ennis,et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. , 2001, The New England journal of medicine.
[145] S. Huang,et al. Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. , 2000, Experimental cell research.
[146] A. Khomenko,et al. Standard short-course chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countries. , 2000, JAMA.
[147] T G Myers,et al. DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. , 1999, Journal of the National Cancer Institute.
[148] S. Hammer,et al. Antiretroviral therapy for HIV infection in 1998: updated recommendations of the International AIDS Society-USA Panel. , 1997, JAMA.
[149] Zhen-yi Wang,et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. , 1988, Haematology and blood transfusion.
[150] M. Berenbaum. The expected effect of a combination of agents: the general solution. , 1985, Journal of theoretical biology.
[151] R. Jackson,et al. Kinetic simulation of anticancer drug interactions. , 1980, International journal of bio-medical computing.
[152] Goldie Jh,et al. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. , 1979 .
[153] R T Schimke,et al. Gene amplification and drug resistance in cultured murine cells. , 1978, Science.
[154] R L Juliano,et al. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. , 1976, Biochimica et biophysica acta.
[155] R C Young,et al. Combination versus single agent chemotherapy: A review of the basis for selection of drug treatment of cancer , 1975, Cancer.
[156] S. Loewe,et al. Die quantitativen Probleme der Pharmakologie , 1928 .
[157] D. Lauffenburger,et al. Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models , 2011 .
[158] A. Kibel. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study: Scher HI, the Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Consortium (Memorial Sloan-Kettering Cancer Ctr, NY; et al) Lancet 375:1437-1446, 2010 § , 2011 .
[159] Razelle Kurzrock,et al. Combining targeted therapies: practical issues to consider at the bench and bedside. , 2010, The oncologist.
[160] J. Salk. Clonal evolution in cancer , 2010 .
[161] A. Joe,et al. Oncogene addiction. , 2008, Cancer research.
[162] Raymond A. Molnar,et al. Molecular Systems Biology 3; Article number 80; doi:10.1038/msb4100116 Citation: Molecular Systems Biology 3:80 , 2022 .
[163] E. Petricoin,et al. Modeling of protein signaling networks in clinical proteomics. , 2005, Cold Spring Harbor symposia on quantitative biology.
[164] B. Stockwell,et al. Multicomponent therapeutics for networked systems , 2005, Nature Reviews Drug Discovery.
[165] B. Chabner,et al. Chemotherapy and the war on cancer , 2005, Nature Reviews Cancer.
[166] Martin S. Hirsch,et al. Treatment for adult HIV infection. , 2004 .
[167] Adam J. Smith,et al. The Database of Interacting Proteins: 2004 update , 2004, Nucleic Acids Res..
[168] M. Gottesman. Mechanisms of cancer drug resistance. , 2002, Annual review of medicine.
[169] Pierre Morel,et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. , 2002, The New England journal of medicine.
[170] Ioannis Xenarios,et al. DIP: The Database of Interacting Proteins: 2001 update , 2001, Nucleic Acids Res..
[171] A. D. Lunn,et al. The Data Sets , 1994 .
[172] T. Chou,et al. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. , 1984, Advances in enzyme regulation.
[173] J H Goldie,et al. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. , 1979, Cancer treatment reports.
[174] R. Jackson,et al. Enzyme kinetics and combination chemotherapy: an appraisal of current concepts. , 1975, Advances in enzyme regulation.
[175] R. W. Brockman,et al. MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS. , 1963, Advances in cancer research.