Light dosimetry model for photodynamic therapy treatment planning

A light dosimetry model for photodynamic therapy is described leading to the dependence of necrosis depth on incident light dose. Semiempirical dosimetry relations are derived for four modes of light delivery. Results for Photofrin® II at 630 nm are summarized in graphical form. Numerical values of the parameters and necrosis depth calculations are compared with literature data.

[1]  L. O. Svaasand,et al.  Thermal and Optical Dosimetry for Photoradiation Therapy of Malignant Tumors , 1984 .

[2]  R Cubeddu,et al.  PHOTOPHYSICAL PROPERTIES OF PORPHYRIN‐CHLORIN SYSTEMS IN THE PRESENCE OF SURFACTANTS , 1987, Photochemistry and photobiology.

[3]  L. O. Svaasand,et al.  OPTICAL PROPERTIES OF HUMAN BRAIN , 1983, Photochemistry and photobiology.

[4]  L. O. Svaasand,et al.  OPTICAL PENETRATION IN HUMAN INTRACRANIAL TUMORS , 1985, Photochemistry and photobiology.

[5]  A E Profio,et al.  Light transport in tissue. , 1989, Applied optics.

[6]  James H. Hill,et al.  PHOTODYNAMIC THERAPY OF HEAD and NECK SQUAMOUS CELL CARCINOMA: OPTICAL DOSIMETRY and CLINICAL TRIAL , 1987, Photochemistry and photobiology.

[7]  W. Potter,et al.  PDT Dosimetry And Response , 1989 .

[8]  F. P. Bolin,et al.  Refractive index of some mammalian tissues using a fiber optic cladding method. , 1989, Applied optics.

[9]  A E Profio,et al.  TRANSPORT OF LIGHT IN TISSUE IN PHOTODYNAMIC THERAPY , 1987, Photochemistry and photobiology.

[10]  A E Profio,et al.  Laser-induced hyperthermia of ocular tumors. , 1989, Applied optics.

[11]  Thomas S. Mang,et al.  THE THEORY OF PHOTODYNAMIC THERAPY DOSIMETRY: CONSEQUENCES OF PHOTO‐DESTRUCTION OF SENSITIZER , 1987 .

[12]  H. A. Ferwerda,et al.  Scattering and absorption of turbid materials determined from reflection measurements. 1: theory. , 1983, Applied optics.

[13]  M. V. van Gemert,et al.  Light dosimetry: status and prospects. , 1987, Journal of photochemistry and photobiology. B, Biology.

[14]  G. H. Gijsbers,et al.  Wavelength and light-dose dependence in tumour phototherapy with haematoporphyrin derivative. , 1985, British Journal of Cancer.

[15]  Steven L. Jacques.  Simple Theory, Measurements, And Rules Of Thumb For Dosimetry During Photodynamic Therapy. , 1989 .

[16]  T J Dougherty,et al.  PHOTOSENSITIZERS: THERAPY AND DETECTION OF MALIGNANT TUMORS , 1987, Photochemistry and photobiology.

[17]  Optical dosimetry in photodynamic therapy , 1986, Lasers in surgery and medicine.

[18]  Leonard I. Grossweiner,et al.  Treatment planning for photodynamic therapy: semi-empirical model and clinical trials on head and neck carcinoma , 1990, Photonics West - Lasers and Applications in Science and Engineering.

[19]  A E Profio,et al.  Light dosimetry in tissue: application to photoradiation therapy. , 1983, Advances in experimental medicine and biology.

[20]  A E Profio,et al.  Fluorescence of HpD for tumor detection and dosimetry in photoradiation therapy. , 1984, Progress in clinical and biological research.

[21]  M F Mafee,et al.  Photodynamic therapy in the treatment of squamous cell carcinoma of the head and neck. , 1990, Archives of otolaryngology--head & neck surgery.

[22]  L. Grossweiner,et al.  Applications of the 1-D diffusion approximation to the optics of tissues and tissue phantoms. , 1989, Applied optics.

[23]  S L Jacques,et al.  Pulsed photothermal radiometry in turbid media: internal reflection of backscattered radiation strongly influences optical dosimetry. , 1989, Applied optics.

[24]  J Moan,et al.  PHOTOBLEACHING OF PORPHYRINS USED IN PHOTODYNAMIC THERAPY AND IMPLICATIONS FOR THERAPY , 1987, Photochemistry and photobiology.

[25]  M S Patterson,et al.  In vivo TESTS OF THE CONCEPT OF PHOTODYNAMIC THRESHOLD DOSE IN NORMAL RAT LIVER PHOTOSENSITIZED BY ALUMINUM CHLOROSULPHONATED PHTHALOCYANINE , 1990, Photochemistry and photobiology.