What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2019? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society

The International Liver Transplantation Society (ILTS) 2019 Annual Congress was held in Toronto, Canada, in May 2019. Members of the ILTS Basic and Translational Research Committee attended all sessions of the meeting and selected the most promising, innovative, and novel research presented. A total of 900 abstracts were presented at the meeting. The percentage of abstracts presented at the ILTS Congress that contains basic or translational research continues to increase, accounting for 15% of all the abstracts in 2019, up from 10% in 2018. Here, we summarize the “what’s hot what’s new” in 5 main themes: liver immunobiology and tolerance, ischemia/reperfusion injury and organ preservation, bioengineering and liver regeneration, hepatic primary tumor biology, and pathophysiology of liver failure.

[1]  J. Teckman,et al.  Liver disease with unknown etiology – have you ruled out alpha-1 antitrypsin deficiency? , 2021, Therapeutic advances in chronic disease.

[2]  F. Tacke,et al.  Hypothermic Oxygenated Machine Perfusion Reduces Early Allograft Injury and Improves Post-transplant Outcomes in Extended Criteria Donation Liver Transplantation From Donation After Brain Death , 2021, Annals of surgery.

[3]  S. Del Turco,et al.  Comparison between galectin-3 and YKL-40 levels for the assessment of liver fibrosis in cirrhotic patients. , 2021, Arab Journal of Gastroenterology.

[4]  N. Heaton,et al.  Hypothermic Machine Perfusion in Liver Transplantation - A Randomized Trial. , 2021, The New England journal of medicine.

[5]  D. Crawford,et al.  Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury , 2020, International journal of molecular sciences.

[6]  S. Curbishley,et al.  Transplantation of discarded livers following viability testing with normothermic machine perfusion , 2020, Nature Communications.

[7]  Shuyun Liu,et al.  26: Mesenchymal Stem Cells (MSCs) Ameliorate Acute Kidney Injury Through Enhancing mtDNA transcription and Mitochondrial Biogenesis , 2019, Transplantation.

[8]  R. D. de Kleine,et al.  Biliary Bicarbonate, pH, and Glucose Are Suitable Biomarkers of Biliary Viability During Ex Situ Normothermic Machine Perfusion of Human Donor Livers , 2019, Transplantation.

[9]  D. Meierhofer,et al.  PS-168-Novel real time prediction of liver graft function during hypothermic oxygenated machine perfusion prior to liver transplantation , 2019, Journal of Hepatology.

[10]  C. Ceresa.  Novel approaches in optimising steatotic livers for transplantation , 2018 .

[11]  Timothy Block,et al.  Glycosylation and liver cancer. , 2015, Advances in cancer research.

[12]  S. Bramhall,et al.  Aetiology and risk factors of ischaemic cholangiopathy after liver transplantation. , 2014, World journal of gastroenterology.

[13]  E. Mercken,et al.  RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression , 2013, Cell reports.

[14]  D. Schuppan,et al.  Progression of liver fibrosis in post-transplant hepatitis C: mechanisms, assessment and treatment. , 2013, Journal of hepatology.

[15]  M. Manns,et al.  A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration , 2013, Cell.

[16]  O. Dirsch,et al.  Early release of macrophage migration inhibitory factor after liver ischemia and reperfusion injury in rats. , 2012, Cytokine.

[17]  G. Vasta,et al.  Roles of galectins in infection , 2009, Nature Reviews Microbiology.