Alzheimer’s Disease—A Dysfunction in Cholesterol and Lipid Metabolism

[1]  H. McKee,et al.  Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration. , 2004, American journal of ophthalmology.

[2]  W. Lukiw.  Gene Expression Profiling in Fetal, Aged, and Alzheimer Hippocampus: A Continuum of Stress-Related Signaling , 2004, Neurochemical Research.

[3]  K. Blennow,et al.  Plasma Levels of β-Amyloid(1-40), β-Amyloid(1-42), and Total β-Amyloid Remain Unaffected in Adult Patients With Hypercholesterolemia After Treatment With Statins , 2004 .

[4]  M. Mattson,et al.  Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Lewis H Kuller,et al.  Incidence and Prevalence of Dementia in the Cardiovascular Health Study , 2004, Journal of the American Geriatrics Society.

[6]  B. Austen,et al.  Proteolytic cascade in the amyloidogenesis of Alzheimer's disease. , 2004, Biochemical Society transactions.

[7]  B. Hyman,et al.  Beta-secretase activity increases with aging in human, monkey, and mouse brain. , 2004, The American journal of pathology.

[8]  Joanna L. Jankowsky,et al.  Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase , 2004 .

[9]  L. Miller,et al.  The Role of Cholesterol and Statins in Alzheimer's Disease , 2004, The Annals of pharmacotherapy.

[10]  J. Shioi,et al.  Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity* , 2003, Journal of Biological Chemistry.

[11]  R. Moore,et al.  Statins in hypercholesterolaemia: A dose-specific meta-analysis of lipid changes in randomised, double blind trials , 2003, BMC family practice.

[12]  S. Noy,et al.  The Role of Cardiovascular Risk Factors in Alzheimer's Disease , 2003, CNS Spectrums.

[13]  Song‐Pyo Hong,et al.  Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression* , 2003, Journal of Biological Chemistry.

[14]  R. Sperling,et al.  Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program. , 2003, American heart journal.

[15]  Ramón Cacabelos,et al.  Cerebrovascular risk factors in Alzheimer's disease: Brain hemodynamics and pharmacogenomic implications , 2003, Neurological research.

[16]  J. Baudry,et al.  Aβ, aging, and Alzheimer's disease: A tale, models, and hypotheses , 2003, Neurological research.

[17]  D. Lütjohann,et al.  24S-Hydroxycholesterol: a Marker of Brain Cholesterol Metabolism , 2003, Pharmacopsychiatry.

[18]  J. H. Boo,et al.  Lovastatin enhances Aβ production and senile plaque deposition in female Tg2576 mice , 2003, Neurobiology of Aging.

[19]  S. Pasternak,et al.  The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective. , 2003, Journal of Alzheimer's disease : JAD.

[20]  L. Thal,et al.  Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology , 2003, Neurology.

[21]  G. Vega,et al.  Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients , 2003, Neurology.

[22]  S. Youssef,et al.  Statins as potential therapeutic agents in neuroinflammatory disorders. , 2003, Current opinion in neurology.

[23]  T. Golde,et al.  Overexpression of nicastrin increases Aß production , 2003 .

[24]  Rudolph E. Tanzi,et al.  Alzheimer's disease: the cholesterol connection , 2003, Nature Neuroscience.

[25]  U. Igbavboa,et al.  Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease. , 2003, Biochimica et biophysica acta.

[26]  M. Ball,et al.  Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signaling , 2002, Journal of neuroscience research.

[27]  N. Bazan,et al.  Prostaglandins and other lipid mediators in Alzheimer's disease. , 2002, Prostaglandins & other lipid mediators.

[28]  B. Strooper,et al.  FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction , 2002, Neurobiology of Aging.

[29]  J. Dietschy,et al.  Cholesterol metabolism in the brain , 2001, Current opinion in lipidology.

[30]  C. Schweiger.  [Statins and the risk of dementia]. , 2001, Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology.

[31]  G. Celesia,et al.  Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. , 2000, Archives of neurology.

[32]  D. Schenk.  Alzheimer's disease: A partner for presenilin , 2000, Nature.

[33]  Ruedi Aebersold,et al.  Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing , 2000, Nature.

[34]  D. R. Gross,et al.  Link between heart disease, cholesterol, and Alzheimer's disease: A review , 2000, Microscopy research and technique.

[35]  Rong Wang,et al.  Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model , 2000, Neurobiology of Disease.

[36]  D J Stephens,et al.  The role of cholesterol in the biosynthesis of beta-amyloid. , 1999, Neuroreport.

[37]  U. Igbavboa,et al.  Recent advances in brain cholesterol dynamics: Transport, domains, and Alzheimer's disease , 1999, Lipids.

[38]  T. Mizuno,et al.  Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells. , 1998, Biochimica et biophysica acta.

[39]  B. Strooper,et al.  Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[40]  M. Smith,et al.  Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. , 1998, The American journal of pathology.

[41]  Patrick L. McGeer,et al.  Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease , 1996, Neurology.

[42]  W. Klein,et al.  Cholesterol Modulates -Secretase Cleavage of Amyloid Precursor Protein (*) , 1996, The Journal of Biological Chemistry.

[43]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[44]  C. Newschaffer,et al.  Aging and total cholesterol levels: cohort, period, and survivorship effects. , 1992, American journal of epidemiology.

[45]  L. Herbette,et al.  Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol , 1992, Neurobiology of Aging.

[46]  N. Robakis,et al.  Immunohistochemical evidence of antioxidant stress in Alzheimer's disease , 1992 .

[47]  S. M. Sumi,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) , 1991, Neurology.

[48]  K. Duff,et al.  Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol , 2007, Journal of Molecular Neuroscience.

[49]  D. Borchelt,et al.  Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. , 2004, Human molecular genetics.

[50]  K. Blennow,et al.  Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins. , 2004, Archives of neurology.

[51]  H. Kölsch,et al.  The role of 24S-hydroxycholesterol in Alzheimer's disease. , 2003, The journal of nutrition, health & aging.

[52]  T. Golde,et al.  Overexpression of nicastrin increases Abeta production. , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[53]  J. Shioi,et al.  Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. , 2003, The Journal of biological chemistry.

[54]  L. Launer.  Nonsteroidal anti-inflammatory drug use and the risk for Alzheimer's disease: dissecting the epidemiological evidence. , 2003, Drugs.

[55]  B. Wolozin.  Cyp46 (24S-cholesterol hydroxylase): a genetic risk factor for Alzheimer disease. , 2003, Archives of neurology.

[56]  H. Braak,et al.  Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. , 2003, Archives of neurology.

[57]  F. Licastro,et al.  Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits. , 2002, Journal of Alzheimer's disease : JAD.

[58]  B. de Strooper,et al.  FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction. , 2002, Neurobiology of aging.

[59]  D. Holtzman,et al.  Clearance of amyloid beta-peptide from brain: transport or metabolism? , 2000, Nature medicine.

[60]  W. Grant.  Dietary links to Alzheimer's disease: 1999 update. , 1999, Journal of Alzheimer's disease : JAD.

[61]  M. Emmerling,et al.  Amyloid and lipids in the pathology of Alzheimer disease. , 1999, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

[62]  A. Nissinen,et al.  Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. , 1998, Neuroepidemiology.

[63]  W. Grant.  Dietary Links to Alzheimer's Disease , 1997 .

[64]  W. Klein,et al.  Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. , 1996, The Journal of biological chemistry.