Semi‐automated risk estimation using large databases: quinolones and clostridium difficile associated diarrhea

The availability of large databases with person time information and appropriate statistical methods allow for relatively rapid pharmacovigilance analyses. A semi‐automated method was used to investigate the effect of fluoroquinolones on the incidence of C. difficile associated diarrhea (CDAD).

[1]  C. Surawicz,et al.  Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients. , 1990, The Journal of infectious diseases.

[2]  A. Barkun,et al.  Patterns of antibiotic use and risk of hospital admission because of Clostridium difficile infection , 2008, Canadian Medical Association Journal.

[3]  G. Raugi,et al.  Implications of the changing face of Clostridium difficile disease for health care practitioners. , 2007, American journal of infection control.

[4]  R. Gaynes,et al.  Outbreak of Clostridium difficile infection in a long-term care facility: association with gatifloxacin use. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  F. Vekeman,et al.  Drug utilisation and cost considerations of erythropoiesis stimulating agents in oncology patients receiving chemotherapy: observations from a large managed-care database , 2009, Journal of medical economics.

[6]  L. Mcfarland.  Renewed interest in a difficult disease: Clostridium difficile infections – epidemiology and current treatment strategies , 2009, Current opinion in gastroenterology.

[7]  S. Meyers.  Clostridium difficile Colitis , 1999, American Journal of Gastroenterology.

[8]  T. Riley,et al.  Ciprofloxacin and Clostridium difficile-associated diarrhoea. , 1991, The Journal of infection.

[9]  B. Dale,et al.  Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea. , 2003, The Journal of hospital infection.

[10]  R. Barton,et al.  Clindamycin-associated colitis. A prospective study. , 1974, Annals of internal medicine.

[11]  A. Huang,et al.  Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case–control studies , 2004, Canadian Medical Association Journal.

[12]  C. Nord,et al.  Frequency of antibiotic-associated diarrhoea in 2462 antibiotic-treated hospitalized patients: a prospective study. , 2001, The Journal of antimicrobial chemotherapy.

[13]  M. Stevenson,et al.  Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review. , 2003, The Journal of antimicrobial chemotherapy.

[14]  E. Frome.  The analysis of rates using Poisson regression models. , 1983, Biometrics.

[15]  M. Loeb,et al.  Quinolone Use as a Risk Factor for Nosocomial Clostridium difficile-Associated Diarrhea , 2001, Infection Control & Hospital Epidemiology.

[16]  K. Nelson,et al.  The role of physical proximity in nosocomial diarrhea. , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[17]  J Urquhart,et al.  Channeling bias in the interpretation of drug effects. , 1991, Statistics in medicine.

[18]  V. Fraser,et al.  Prevalence of Clostridium difficile environmental contamination and strain variability in multiple health care facilities. , 2007, American journal of infection control.

[19]  A. Harris,et al.  difficile–associated Diarrhea , 2022 .

[20]  M. Kollef,et al.  Increase in Adult Clostridium difficile–related Hospitalizations and Case-Fatality Rate, United States, 2000–2005 , 2008, Emerging infectious diseases.

[21]  D. Gerding.  Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[22]  A. M. Walker,et al.  An application of propensity score matching using claims data , 2005, Pharmacoepidemiology and drug safety.

[23]  Phillip W. Lord,et al.  Semantic Similarity in Biomedical Ontologies , 2009, PLoS Comput. Biol..

[24]  L. Lanthier,et al.  Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[25]  Louis Valiquette,et al.  Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity , 2004, Canadian Medical Association Journal.

[26]  Carlene A. Muto,et al.  Antimicrobial-associated risk factors for Clostridium difficile infection. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.