Synthesis, Structure Analysis, and Antitumor Activity of (R)‐2,4‐Dioxo‐5‐fluoro‐1‐[1‐(methoxycarbonyl) Ethylaminocarbonylmethyl]‐1,2,3,4‐tetrahydropyrimidine

A new dipeptide compound, (R)-2,4-dioxo-5-fluoro-1-[1-(methoxycarbonyl) ethylaminocarbonylmethyl]-1,2,3, 4-tetrahydropyrimidine (5-FUAPM), has been synthesized and identified by means of elemental analysis, IR, 1H NMR and 13C NMR spectra. The single crystal of compound 5-FUAPM·DMF was also obtained and characterized by DSC-TGA techniques. The crystal belongs to orthorhombic space group P2121 21 with the cell parameters: a=0.4740(7) nm, b=1.923(3) nm, c=1.9229 nm, α=β=γ=90°, V=1.753 nm3, Z=4, Dc=1.312 g/cm3, Mr=346.32, F(000) =728 and μ=0.111 mm−1. The final R and wR are 0.1378 and 0.2862, respectively. The result of the biological test showed that the compound 5-FUAPM has certain antitumor activities.

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