Exercise triggers ARVC phenotype in mice expressing a disease-causing mutated version of human plakophilin-2.

[1]  G. Thiene,et al.  Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). , 2004, Heart rhythm.

[2]  S. Russell,et al.  Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. , 2013, Journal of the American College of Cardiology.

[3]  R. Gourdie,et al.  The connexin43 carboxyl terminus and cardiac gap junction organization. , 2012, Biochimica et biophysica acta.

[4]  D. Fenyö,et al.  Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque. , 2013, Cardiovascular research.

[5]  W. Birchmeier,et al.  Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. , 2012, Cardiovascular research.

[6]  G. Thiene,et al.  Adipositas cordis, fatty infiltration of the right ventricle, and arrhythmogenic right ventricular cardiomyopathy. Just a matter of fat? , 2005, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[7]  A. Jaffe,et al.  Transient right but not left ventricular dysfunction after strenuous exercise at high altitude. , 1997, Journal of the American College of Cardiology.

[8]  R. Hauer,et al.  Plakophilin-2 Mutations Are the Major Determinant of Familial Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy , 2006, Circulation.

[9]  H. Calkins,et al.  Shared Desmosome Gene Findings in Early and Late Onset Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy , 2010, Journal of cardiovascular translational research.

[10]  G. Guerrero-Serna,et al.  Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes , 2009, Circulation Research.

[11]  D. Corrado,et al.  Right ventricular cardiomyopathy and sudden death in young people. , 1988, The New England journal of medicine.

[12]  Michael J Ackerman,et al.  Recommendations for physical activity and recreational sports participation for young patients with genetic cardiovascular diseases. , 2004, Circulation.

[13]  J. Towbin,et al.  Genetics of arrhythmogenic right ventricular cardiomyopathy: a practical guide for physicians. , 2013, Journal of the American College of Cardiology.

[14]  G. Danieli,et al.  Ultrastructural evidence of intercalated disc remodelling in arrhythmogenic right ventricular cardiomyopathy: an electron microscopy investigation on endomyocardial biopsies. , 2006, European heart journal.

[15]  R. Hauer,et al.  Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. , 2013, Heart rhythm.

[16]  Stefan L. Zimmerman,et al.  Yield of serial evaluation in at-risk family members of patients with ARVD/C. , 2014, Journal of the American College of Cardiology.

[17]  Walter Birchmeier,et al.  Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy , 2004, Nature Genetics.

[18]  Stefan L. Zimmerman,et al.  Incremental value of cardiac magnetic resonance imaging in arrhythmic risk stratification of arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. , 2013, Journal of the American College of Cardiology.

[19]  Jan Bogaert,et al.  Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. , 2012, European heart journal.

[20]  G. Breithardt,et al.  Connexin expression patterns in arrhythmogenic right ventricular cardiomyopathy. , 2013, The American journal of cardiology.

[21]  H. Calkins,et al.  Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy , 2014, Science Translational Medicine.

[22]  J. Saffitz,et al.  Distinct Pathways Regulate Expression of Cardiac Electrical and Mechanical Junction Proteins in Response to Stretch , 2005, Circulation research.

[23]  M. Link,et al.  Ventricular arrhythmias in the North American multidisciplinary study of ARVC: predictors, characteristics, and treatment. , 2014, Journal of the American College of Cardiology.

[24]  Hugh Calkins,et al.  A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. , 2008, The New England journal of medicine.

[25]  G. Thiene,et al.  Arrhythmogenic Cardiomyopathy: Transgenic Animal Models Provide Novel Insights Into Disease Pathobiology , 2011, Circulation. Cardiovascular genetics.

[26]  S. Rizzo,et al.  The changing spectrum of arrhythmogenic (right ventricular) cardiomyopathy , 2012, Cell and Tissue Research.

[27]  B. Sievers,et al.  Journal of Cardiovascular Magnetic Resonance Right Ventricular Wall Motion Abnormalities Found in Healthy Subjects by Cardiovascular Magnetic Resonance Imaging and Characterized with a New Segmental Model , 2022 .

[28]  P. Elliott,et al.  Clinical Expression of Plakophilin-2 Mutations in Familial Arrhythmogenic Right Ventricular Cardiomyopathy , 2006, Circulation.

[29]  R. Hauer,et al.  Arrhythmogenic right ventricular dysplasia/cardiomyopathy according to revised 2010 task force criteria with inclusion of non-desmosomal phospholamban mutation carriers. , 2013, The American journal of cardiology.

[30]  L. Jordaens,et al.  Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Pathogenic Desmosome Mutations in Index-Patients Predict Outcome of Family Screening Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Genotype-Phenotype Follow-Up Study , 2011, Circulation.

[31]  J. D. de Bakker,et al.  Cardiac connexins and impulse propagation. , 2010, Journal of molecular and cellular cardiology.

[32]  Hein Heidbüchel,et al.  Disproportionate exercise load and remodeling of the athlete's right ventricle. , 2011, Medicine and science in sports and exercise.

[33]  J. Brugada,et al.  Cardiac Arrhythmogenic Remodeling in a Rat Model of Long-Term Intensive Exercise Training , 2011, Circulation.

[34]  W. McKenna,et al.  The Cardiac Desmosome and Arrhythmogenic Cardiomyopathies: From Gene to Disease , 2010, Circulation research.

[35]  S. Acton,et al.  Robust Cardiomyocyte-Specific Gene Expression Following Systemic Injection of AAV: In Vivo Gene Delivery Follows a Poisson Distribution , 2010, Gene Therapy.

[36]  A. Waldo.  Activation Delay and VT Parameters in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Toward Improvement of Diagnostic ECG Criteria , 2009 .

[37]  K. Green,et al.  Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc , 2011, Circulation research.

[38]  G. Breithardt,et al.  Age- and Training-Dependent Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Heterozygous Plakoglobin-Deficient Mice , 2006, Circulation.

[39]  D. Corrado,et al.  Arrhythmogenic Right Ventricular Cardiomyopathy. , 2010, Cardiac electrophysiology clinics.

[40]  Wojciech Zareba,et al.  Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Proposed Modification of the Task Force Criteria , 2010, Circulation.

[41]  Mario Delmar,et al.  Cardiac connexins, mutations and arrhythmias , 2012, Current opinion in cardiology.