Essential role of aldehyde dehydrogenase 1 A 3 ( ALDH 1 A 3 ) for the maintenance of non-small cell lung cancer stem cells is associated with the STAT 3 pathway

Chunli Shao1,2, James P. Sullivan3, Luc Girard1,2, Alexander Augustyn1,2, Paul Yenerall1,2, Jaime Rodriguez4, Hui Liu4, Carmen Behrens4, Jerry W. Shay5, Ignacio I. Wistuba4, John D. Minna 1,2,6,7 Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, Department of Translational Molecular Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77054, Department of Cell Biology, Department of Pharmacology, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.

[1]  N. Maitland,et al.  JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells. , 2013, Cancer research.

[2]  P. Russell,et al.  The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer , 2013, Thorax.

[3]  D. Nam,et al.  Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. , 2013, Cancer cell.

[4]  J. Shih,et al.  ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors. , 2013, Cancer letters.

[5]  M. McCarter,et al.  ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets , 2012, Stem cells.

[6]  J. Visvader,et al.  Cancer stem cells: current status and evolving complexities. , 2012, Cell stem cell.

[7]  M. Roizen,et al.  Hallmarks of Cancer: The Next Generation , 2012 .

[8]  Li Lin,et al.  STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. , 2011, Cancer research.

[9]  R. Ferris,et al.  Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells , 2011, Clinical Cancer Research.

[10]  P. Marcato,et al.  Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform , 2011, Cell cycle.

[11]  Surendra Singh,et al.  Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. , 2011, Biochemical and biophysical research communications.

[12]  Patrick W. Lee,et al.  Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis , 2011, Stem cells.

[13]  A. Allan,et al.  The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells , 2011, Stem Cell Reviews and Reports.

[14]  Laura A. Sullivan,et al.  Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. , 2010, Cancer research.

[15]  L. Nicholson,et al.  Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose? , 2010, The Journal of pathology.

[16]  P. Andrews,et al.  Retinoic acid directs neuronal differentiation of human pluripotent stem cell lines in a non-cell-autonomous manner. , 2010, Differentiation; research in biological diversity.

[17]  F. Hamdy,et al.  High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer. , 2010, Cancer research.

[18]  D. Birnbaum,et al.  CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. , 2010, The Journal of clinical investigation.

[19]  I. Herr,et al.  CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non‐small cell lung cancer patients , 2009, International journal of cancer.

[20]  F. Bertucci,et al.  Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer , 2009, Clinical Cancer Research.

[21]  F. Bertucci,et al.  Retinoid signaling regulates breast cancer stem cell differentiation , 2009, Cell cycle.

[22]  L. Mariani,et al.  Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment , 2009, Proceedings of the National Academy of Sciences.

[23]  Feng Jiang,et al.  Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer , 2009, Molecular Cancer Research.

[24]  B. Levi,et al.  Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. , 2009, Blood.

[25]  F. Bertucci,et al.  Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. , 2009, Cancer research.

[26]  F. Gonzalez,et al.  Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C/EBPbeta interaction. , 2009, Biochemical pharmacology.

[27]  H. Baker,et al.  ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells , 2008, Molecular Cancer.

[28]  J. Visvader,et al.  Cancer stem cells in solid tumours: accumulating evidence and unresolved questions , 2008, Nature Reviews Cancer.

[29]  Anna E. Lokshin,et al.  Drug-Selected Human Lung Cancer Stem Cells: Cytokine Network, Tumorigenic and Metastatic Properties , 2008, PloS one.

[30]  C. Brocker,et al.  Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily , 2008, Expert opinion on drug metabolism & toxicology.

[31]  Yang Xie,et al.  Enhanced identification and biological validation of differential gene expression via Illumina whole-genome expression arrays through the use of the model-based background correction methodology , 2008, Nucleic acids research.

[32]  Lakshmaiah Sreerama,et al.  ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors. , 2008, Lung cancer.

[33]  M. Biffoni,et al.  Identification and expansion of the tumorigenic lung cancer stem cell population , 2008, Cell Death and Differentiation.

[34]  J. Moreb,et al.  Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry‐based assay , 2007, Cytometry. Part B, Clinical cytometry.

[35]  Stephen Lam,et al.  Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. , 2007, Cancer research.

[36]  A. Cheung,et al.  Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential , 2007, Leukemia.

[37]  J. Whitesides,et al.  Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. Clarke,et al.  Stem Cells and Cancer: Two Faces of Eve , 2006, Cell.

[39]  D. Mohuczy,et al.  Retinoic Acid Down-Regulates Aldehyde Dehydrogenase and Increases Cytotoxicity of 4-Hydroperoxycyclophosphamide and Acetaldehyde , 2005, Journal of Pharmacology and Experimental Therapeutics.

[40]  G. Duester,et al.  Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid. , 2003, Chemico-biological interactions.

[41]  Lakshmaiah Sreerama,et al.  Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study , 2002, Cancer Chemotherapy and Pharmacology.

[42]  C. Bloomfield,et al.  All-trans-retinoic acid in acute promyelocytic leukemia. , 1997, The New England journal of medicine.

[43]  M. Schweder,et al.  Overexpression of the human aldehyde dehydrogenase class I results in increased resistance to 4-hydroperoxycyclophosphamide. , 1996, Cancer gene therapy.

[44]  J. Minna,et al.  Human lung cancer cell lines exhibit resistance to retinoic acid treatment. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.