An Integrated Approach From Disease To Prevention

Seasonal influenza, more commonly referred to as “flu” is an acute viral infection caused by an influenza virus. The virus circulates worldwide and can affect anybody, in any age group. The clinical features and complications associated with the disease are highlighted in Table 1. There are 3 types of seasonal influenza viruses – A, B and C. Type A influenza viruses are further classified into subtypes according to the combinations of various virus surface proteins. Among many subtypes of influenza A viruses, influenza A (H1N1) and A (H3N2) subtypes are currently circulating amongst humans. WHO, with its partners, monitors influenza globally, recommends seasonal influenza vaccine compositions twice a year for the Northern and Southern hemispheres, and supports member states efforts to develop prevention and control strategies. WHO works to strengthen national and regional influenza diagnostic capacities including antiviral susceptibility monitoring, disease surveillance, outbreak responses, and increases vaccine coverage among highrisk group.

[1]  L. Abbate Risk of Narcolepsy in Children and Young People Receiving AS03 Adjuvanted Pandemic A/H1N1 2009 Influenza Vaccine: Retrospective Analysis , 2013 .

[2]  B. Gessner,et al.  Seasonal influenza epidemiology in sub-Saharan Africa: a systematic review. , 2011, The Lancet. Infectious diseases.

[3]  R. Walker,et al.  Live attenuated versus inactivated influenza vaccine in infants and young children. , 2007, The New England journal of medicine.

[4]  L. Finelli,et al.  Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010. , 2010, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[5]  Ross E. G. Upshur,et al.  Guillain-Barré syndrome after influenza vaccination in adults: a population-based study. , 2006, Archives of internal medicine.

[6]  A. Monto,et al.  Comparative efficacy of inactivated and live attenuated influenza vaccines. , 2009, The New England journal of medicine.

[7]  W. P. Glezen,et al.  Maternal immunization with influenza or tetanus toxoid vaccine for passive antibody protection in young infants. , 1993, The Journal of infectious diseases.

[8]  E. Shapiro,et al.  Influenza vaccine given to pregnant women reduces hospitalization due to influenza in their infants. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  A. Klimov,et al.  Clinical and epidemiological evaluation of a live, cold-adapted influenza vaccine for 3-14-year-olds. , 1996, Bulletin of the World Health Organization.

[10]  S. Arifeen,et al.  Effectiveness of maternal influenza immunization in mothers and infants. , 2008, The New England journal of medicine.

[11]  G. Dinant,et al.  The Efficacy of Influenza Vaccination in Elderly Individuals: A Randomized Double-blind Placebo-Controlled Trial , 1994 .