Multi-contrast photoacoustic microscopy

We developed multi-contrast photoacoustic microscopy (PAM) for in vivo anatomical, functional, metabolic, and molecular imaging. This technical innovation enables comprehensive understanding of the tumor microenvironment. With multi-contrast PAM, we longitudinally determined tumor vascular anatomy, blood flow, oxygen saturation of hemoglobin, and oxygen extraction fraction.

[1]  Qifa Zhou,et al.  Label-free imaging of zebrafish larvae in vivo by photoacoustic microscopy , 2012, Biomedical optics express.

[2]  R. Pittman,et al.  Method for in vivo microscopy of the cutaneous microcirculation of the hairless mouse ear. , 1980, Microvascular research.

[3]  Qifa Zhou,et al.  Toward dual-wavelength functional photoacoustic endoscopy: laser and peripheral optical systems development , 2012, Photonics West - Biomedical Optics.

[4]  T. Duong,et al.  Imaging oxygen consumption in forepaw somatosensory stimulation in rats under isoflurane anesthesia , 2004, Magnetic resonance in medicine.

[5]  J. Richalet,et al.  Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue , 1998, European Journal of Applied Physiology and Occupational Physiology.

[6]  Rachel L. Mistur,et al.  FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[7]  Lihong V. Wang,et al.  Biomedical Optics: Principles and Imaging , 2007 .

[8]  Lihong V. Wang,et al.  Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries. , 2008, Optics letters.

[9]  W. Kuschinsky,et al.  Patterns of capillary plasma perfusion in brains in conscious rats during normocapnia and hypercapnia. , 1995, Circulation research.

[10]  A. Ruddell,et al.  Lymph node mapping in the mouse. , 2008, Journal of immunological methods.

[11]  James Park,et al.  Behavioral Neurobiology: The Cellular Organization of Natural Behavior , 2002, The Yale Journal of Biology and Medicine.

[12]  Junjie Yao,et al.  Transverse flow imaging based on photoacoustic Doppler bandwidth broadening. , 2010, Journal of biomedical optics.

[13]  J F Greenleaf,et al.  Scattering of ultrasound by tissues. , 1984, Ultrasonic imaging.

[14]  Lihong V. Wang,et al.  Tutorial on Photoacoustic Microscopy and Computed Tomography , 2008, IEEE Journal of Selected Topics in Quantum Electronics.

[15]  Lihong V. Wang,et al.  In vivo photoacoustic microscopy of human skin , 2010 .

[16]  L V Wang,et al.  Realtime photoacoustic microscopy of murine cardiovascular dynamics. , 2008, Optics express.

[17]  Junjie Yao,et al.  VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting , 2011, Proceedings of the National Academy of Sciences.

[18]  F. Srienc,et al.  Dynamics of glucose uptake by single Escherichia coli cells. , 1999, Metabolic engineering.

[19]  Wei Wang,et al.  Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic Tomography , 2008, Proceedings of the IEEE.

[20]  Adrian L. Harris,et al.  Hypoxia — a key regulatory factor in tumour growth , 2002, Nature Reviews Cancer.

[21]  R. Frackowiak,et al.  Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values , 1980, Journal of computer assisted tomography.

[22]  Sh. Kogan,et al.  Electronic noise and fluctuations in solids , 1996 .

[23]  Lihong V Wang,et al.  Photoacoustic tomography and sensing in biomedicine , 2009, Physics in medicine and biology.

[24]  Geng Ku,et al.  Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent. , 2004, Optics letters.

[25]  Alexander A. Oraevsky,et al.  Distribution of the laser radiation intensity in turbid media: Monte Carlo simulations, theoretical analysis, and results of optoacoustic measurements , 2002 .

[26]  Junjie Yao,et al.  In vivo imaging of epileptic activity using 2-NBDG, a fluorescent deoxyglucose analog , 2012, Journal of Neuroscience Methods.

[27]  Hanzhang Lu,et al.  Noninvasive quantification of whole‐brain cerebral metabolic rate of oxygen (CMRO2) by MRI , 2009, Magnetic resonance in medicine.

[28]  Lihong V. Wang,et al.  Functional transcranial brain imaging by optical-resolution photoacoustic microscopy. , 2009, Journal of biomedical optics.

[29]  Lihong V. Wang,et al.  In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. , 2010, Chemical reviews.

[30]  P Perrotte,et al.  Effect of prior therapy on survival after salvage cryotherapy for recurrent prostate cancer , 1999, Prostate Cancer and Prostatic Diseases.

[31]  Zhongping Chen,et al.  Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity. , 2000, Optics letters.

[32]  Junjie Yao,et al.  Noninvasive quantification of metabolic rate of oxygen (MRO2) by photoacoustic microscopy , 2011, BiOS.

[33]  Lihong V. Wang,et al.  Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo. , 2010, Optics letters.

[34]  G. Palade,et al.  Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. , 1995, Journal of cell science.

[35]  N. Hu,et al.  Hemodynamics of the Stage 12 to Stage 29 Chick Embryo , 1989, Circulation research.

[36]  Umar Mahmood,et al.  Evaluation and clinically relevant applications of a fluorescent imaging analog to fluorodeoxyglucose positron emission tomography. , 2009, Journal of biomedical optics.

[37]  Steven L. Jacques,et al.  Depth profiling of absorbing soft materials using photoacoustic methods , 1999 .

[38]  R. Sutherland.  Cell and environment interactions in tumor microregions: the multicell spheroid model. , 1988, Science.

[39]  Avishay Eyal,et al.  Time-resolved photoacoustic Doppler characterization of flow using pulsed excitation , 2010, BiOS.

[40]  G Marchal,et al.  Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging. , 1992, Archives of neurology.

[41]  P. Holt,et al.  Cryotherapy for skin cancer: results over a 5‐year period using liquid nitrogen spray cryosurgery , 1988, The British journal of dermatology.

[42]  W. Fishman,et al.  Combination of Evans blue with plasma protein; its significance in capillary permeability studies, blood dye disappearance curves, and its use as a protein tag. , 1947, The American journal of physiology.

[43]  Rakesh K. Jain,et al.  Quantitative angiogenesis assays: Progress and problems , 1997, Nature Medicine.

[44]  S. Shuster,et al.  Control and function of sebaceous glands. , 1989, Physiological reviews.

[45]  Carmen A. Puliafito,et al.  Collecting back-reflected photons in photoacoustic microscopy , 2010, Optics express.

[46]  R K Jain,et al.  Differential response of normal and tumor microcirculation to hyperthermia. , 1984, Cancer research.

[47]  V. Newhouse,et al.  Ultrasound Doppler Probing of Flows Transverse with Respect to Beam Axis , 1987, IEEE Transactions on Biomedical Engineering.

[48]  Zhixing Xie,et al.  Laser-scanning optical-resolution photoacoustic microscopy. , 2009, Optics letters.

[49]  I. Calasso,et al.  Photoacoustic point source. , 2001, Physical review letters.

[50]  Junjie Yao,et al.  In vivo photoacoustic microscopy with 7.6-µm axial resolution using a commercial 125-MHz ultrasonic transducer , 2012, Journal of biomedical optics.

[51]  E. Russell,et al.  Comparison of Normal Blood Picture of Young Adults from 18 Inbred Strains of Mice , 1951, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[52]  Felix W Wehrli,et al.  MRI Estimation of Global Brain Oxygen Consumption Rate , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[53]  Stanislav Y. Emelianov,et al.  Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents , 2011, Annals of Biomedical Engineering.

[54]  Lihong V. Wang,et al.  In vivo dark-field reflection-mode photoacoustic microscopy. , 2005, Optics letters.

[55]  Wiendelt Steenbergen,et al.  The Twente Photoacoustic Mammoscope: system overview and performance , 2005, Physics in medicine and biology.

[56]  Nisha Charkoudian,et al.  Skin blood flow in adult human thermoregulation: how it works, when it does not, and why. , 2003, Mayo Clinic proceedings.

[57]  B. Tromberg,et al.  Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy. , 2007, Journal of biomedical optics.

[58]  T. Wobbes,et al.  In vivo destruction of tumor tissue by cryoablation can induce inhibition of secondary tumor growth: an experimental study. , 2001, Cryobiology.

[59]  Shuliang Jiao,et al.  Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform. , 2012, Journal of biomedical optics.

[60]  A. Villringer,et al.  Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study. , 1994, Circulation research.

[61]  K. Kirk Shung,et al.  A 3-D High-Frequency Array Based 16 Channel Photoacoustic Microscopy System for In Vivo Micro-Vascular Imaging , 2009, IEEE Transactions on Medical Imaging.

[62]  J. Trosko,et al.  A fluorescence photobleaching assay of gap junction-mediated communication between human cells. , 1986, Science.

[63]  J. McKENDRICK,et al.  The Central Nervous System of Vertebrates , 1909, Nature.

[64]  Lihong V. Wang,et al.  In-vivo photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature. , 2009, Journal of biomedical optics.

[65]  Andrew G. Glen,et al.  APPL , 2001 .

[66]  T. Tadros,et al.  Hepatic blood flow and oxygen consumption after burn and sepsis. , 2000, The Journal of trauma.

[67]  Junjie Yao,et al.  In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth. , 2010, Optics letters.

[68]  W. Le,et al.  Pathological role of hypoxia in Alzheimer's disease , 2010, Experimental Neurology.

[69]  Sheng-Wen Huang,et al.  Photoacoustic correlation spectroscopy and its application to low-speed flow measurement. , 2010, Optics letters.

[70]  Yan Huang,et al.  Induction of angiogenesis in a mouse model using engineered transcription factors , 2002, Nature Medicine.

[71]  Lihong V. Wang,et al.  Photoacoustic Doppler flow measurement in optically scattering media , 2007 .

[72]  J. Folkman,et al.  Is angiogenesis an organizing principle in biology and medicine? , 2007, Journal of pediatric surgery.

[73]  Lihong V Wang,et al.  Universal back-projection algorithm for photoacoustic computed tomography , 2005, SPIE BiOS.

[74]  Zhongping Chen,et al.  Imaging and quantifying transverse flow velocity with the Doppler bandwidth in a phase-resolved functional optical coherence tomography. , 2002, Optics letters.

[75]  Junjie Yao,et al.  Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo. , 2009, Journal of biomedical optics.

[76]  G. Crelier,et al.  Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: The deoxyhemoglobin dilution model , 1999, Magnetic resonance in medicine.

[77]  Junjie Yao,et al.  Label-free oxygen-metabolic photoacoustic microscopy in vivo. , 2011, Journal of biomedical optics.

[78]  Sheng-Wen Huang,et al.  Photoacoustic flow measurements based on wash-in analysis of gold nanorods , 2007, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[79]  J. Pouysségur,et al.  Hypoxia signalling in cancer and approaches to enforce tumour regression , 2006, Nature.

[80]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[81]  R. Cobbold.  Foundations of Biomedical Ultrasound , 2006 .

[82]  Richard Su,et al.  Whole-body three-dimensional optoacoustic tomography system for small animals. , 2009, Journal of biomedical optics.

[83]  K Messmer,et al.  The Hairless Mouse Ear for in Vivo Studies of Skin Microcirculation , 1989, Plastic and reconstructive surgery.

[84]  Quing Zhu,et al.  Curved array photoacoustic tomographic system for small animal imaging. , 2008, Journal of biomedical optics.

[85]  Yoshifumi Kato,et al.  Basic fibroblast growth factor and granulocyte colony-stimulating factor enhance mucosal surface expansion after adult small bowel transplantation without vascular reconstruction in rats. , 2006, Journal of pediatric surgery.

[86]  Hui Fang,et al.  M-mode photoacoustic particle flow imaging. , 2009, Optics letters.

[87]  R. Rogers,et al.  Oxygen consumption of the respiratory muscles in normal and in malnourished patients with chronic obstructive pulmonary disease. , 1989, The American review of respiratory disease.

[88]  Junjie Yao,et al.  Photoacoustic tomography: fundamentals, advances and prospects. , 2011, Contrast media & molecular imaging.

[89]  K. Hunt,et al.  Wide-field imaging of fluorescent deoxy-glucose in ex vivo malignant and normal breast tissue , 2011, Biomedical optics express.

[90]  Martin Oheim,et al.  Two-photon imaging of capillary blood flow in olfactory bulb glomeruli , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[91]  Lihong V. Wang,et al.  Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging , 2006, Nature Biotechnology.

[92]  C. Claussen,et al.  Simultaneous Mr/pet Imaging of the Human Brain: Feasibility Study 1 , 2022 .

[93]  Thomas N. Sato,et al.  Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. , 1999, Science.

[94]  R. Esenaliev,et al.  Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors , 1999 .

[95]  Xinmai Yang,et al.  Growth of melanoma brain tumors monitored by photoacoustic microscopy. , 2010, Journal of biomedical optics.

[96]  Martin Frenz,et al.  Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo , 2005, IEEE Transactions on Medical Imaging.

[97]  E. S. Furgason,et al.  The Dependence of Ultrasound Doppler Bandwidth on Beam Geometry , 1980, IEEE Transactions on Sonics and Ultrasonics.

[98]  W. Hoefnagels,et al.  Simultaneous measurements of cerebral oxygenation changes during brain activation by near‐infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects , 2002, Human brain mapping.

[99]  Liang Song,et al.  Multifocal optical-resolution photoacoustic microscopy in vivo. , 2011, Optics letters.

[100]  O. Bonnefous,et al.  Time Domain Formulation of Pulse-Doppler Ultrasound and Blood Velocity Estimation by Cross Correlation , 1986, Ultrasonic imaging.

[101]  Lihong V. Wang,et al.  Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging. , 2010, Optics letters.

[102]  J. D. de Boer,et al.  Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow. , 2000, Optics letters.

[103]  Lihong V. Wang,et al.  Photoacoustic Doppler effect from flowing small light-absorbing particles. , 2007, Physical review letters.

[104]  Konstantin V Sokolov,et al.  Intravascular Photoacoustic Imaging , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[105]  Edward Z. Zhang,et al.  A miniature all-optical photoacoustic imaging probe , 2011, BiOS.

[106]  F. Stuart Foster,et al.  Femtosecond photoacoustics: integrated two-photon fluorescence and photoacoustic microscopy , 2010, BiOS.

[107]  Junjie Yao,et al.  Fast voice-coil scanning optical-resolution photoacoustic microscopy. , 2011, Optics letters.

[108]  Karthik Vishwanath,et al.  Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors. , 2009, Neoplasia.

[109]  Quing Zhu,et al.  Three-dimensional photoacoustic tomography based on the focal-line concept. , 2011, Journal of biomedical optics.

[110]  Lihong V. Wang,et al.  Second generation optical-resolution photoacoustic microscopy , 2011, BiOS.

[111]  Qifa Zhou,et al.  Integrated ultrasound and photoacoustic probe for co-registered intravascular imaging. , 2011, Journal of biomedical optics.

[112]  Avishay Eyal,et al.  Flow-dependant photothermal modulation of the photoacoustic response , 2012, Photonics West - Biomedical Optics.

[113]  M I GREGERSEN,et al.  Simultaneous measurement in dogs of plasma volume with I131 human albumin and T-1824 with comparisons of their long-term disappearance from the plasma. , 1953, The American journal of physiology.

[114]  Lihong V. Wang,et al.  Photoacoustic imaging and characterization of the microvasculature. , 2010, Journal of biomedical optics.

[115]  T. Byzova,et al.  Angiogenesis in melanoma. , 2007, Seminars in oncology.

[116]  Lihong V. Wang,et al.  In vivo functional human imaging using photoacoustic microscopy: response to ischemic and thermal stimuli , 2010, BiOS.

[117]  Alexander A. Oraevsky,et al.  Optoacoustic tomography: New modality of laser diagnostic systems , 2003 .

[118]  Lihong V. Wang,et al.  In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin. , 2011, Journal of biomedical optics.

[119]  Lihong V. Wang,et al.  Label-free photoacoustic ophthalmic angiography. , 2010, Optics letters.

[120]  Hao Zhang,et al.  Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy , 2007 .

[121]  Lihong V. Wang,et al.  Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs , 2012, Science.

[122]  N. Gaudreault,et al.  Subcellular characterization of glucose uptake in coronary endothelial cells. , 2008, Microvascular research.

[123]  E. Marani,et al.  Photoacoustic Imaging of Brain Perfusion on Albino Rats by Using Evans Blue as Contrast Agent , 2003, Archives of physiology and biochemistry.

[124]  Rong Zhou,et al.  Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk , 2003, Science.

[125]  Lihong V. Wang,et al.  Limitations of quantitative photoacoustic measurements of blood oxygenation in small vessels , 2007, Physics in medicine and biology.

[126]  Klotz Im,et al.  The Binding of Organic Ions by Proteins1 , 1946 .

[127]  Takato Abe,et al.  Fluorometric Determination of Glucose Utilization in Neurons in Vitro and in Vivo , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[128]  Lihong V. Wang.  Multiscale photoacoustic microscopy and computed tomography. , 2009, Nature photonics.

[129]  T Hayakawa,et al.  Preoperative staging of superficial esophageal carcinoma: comparison of an ultrasound probe and standard endoscopic ultrasonography. , 1996, Gastrointestinal endoscopy.

[130]  T. Seyfried,et al.  Cancer as a metabolic disease , 2010, Nutrition & metabolism.

[131]  Julie H. Ostrander,et al.  Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines , 2011, Breast Cancer Research and Treatment.

[132]  J. Mink,et al.  Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis. , 1981, The American journal of physiology.

[133]  C. Kasai,et al.  Real-Time Two-Dimensional Blood Flow Imaging Using an Autocorrelation Technique , 1985, IEEE Transactions on Sonics and Ultrasonics.

[134]  Quing Zhu,et al.  Real-time photoacoustic tomography of cortical hemodynamics in small animals. , 2010, Journal of biomedical optics.

[135]  Zhen Cheng,et al.  Near-infrared fluorescent deoxyglucose analogue for tumor optical imaging in cell culture and living mice. , 2006, Bioconjugate chemistry.

[136]  R. Touloukian,et al.  Ileal Blood Flow Preceding Compensatory Intestinal Hypertrophy , 1972, Annals of surgery.

[137]  Hidenao Fukuyama,et al.  Scopolamine abolishes cerebral blood flow response to somatosensory stimulation in anesthetized cats: PET study , 1994, Brain Research.

[138]  K.-W.W. Yeung,et al.  Angle-insensitive flow measurement using Doppler bandwidth , 1998, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[139]  Qifa Zhou,et al.  A 2.5-mm outer diameter photoacoustic endoscopic mini-probe based on a highly sensitive PMN-PT ultrasonic transducer , 2012, Photonics West - Biomedical Optics.

[140]  Junjie Yao,et al.  Photoacoustic microscopy of microvascular responses to cortical electrical stimulation. , 2011, Journal of biomedical optics.

[141]  Xinmai Yang,et al.  In vivo imaging and treatment of solid tumor using integrated photoacoustic imaging and high intensity focused ultrasound system. , 2010, Medical physics.

[142]  Quing Zhu,et al.  A real-time photoacoustic tomography system for small animals. , 2009, Optics express.

[143]  S L Jacques,et al.  Measurement of tissue optical properties by time-resolved detection of laser-induced transient stress. , 1997, Applied optics.

[144]  R. Buxton,et al.  A Model for the Coupling between Cerebral Blood Flow and Oxygen Metabolism during Neural Stimulation , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[145]  Lihong V. Wang,et al.  Prospects of photoacoustic tomography. , 2008, Medical physics.

[146]  Liang Song,et al.  Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo. , 2010, Journal of biomedical optics.

[147]  M. Raichle,et al.  Appraising the brain's energy budget , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[148]  David F. Rogers,et al.  Laminar Flow Analysis , 1992 .

[149]  Janice A. Nagy,et al.  The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor , 2001, Nature Medicine.

[150]  R. Poldrack,et al.  Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy? , 2003, Physics in medicine and biology.

[151]  Ting-Yim Lee,et al.  Near-Infrared Spectroscopy Measurement of Oxygen Extraction Fraction and Cerebral Metabolic Rate of Oxygen in Newborn Piglets , 2003, Pediatric Research.

[152]  Geng Ku,et al.  Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies. , 2009, Optics express.

[153]  Shuliang Jiao,et al.  Simultaneous dual molecular contrasts provided by the absorbed photons in photoacoustic microscopy. , 2010, Optics letters.

[154]  A. Adamis,et al.  Sensitive blood-retinal barrier breakdown quantitation using Evans blue. , 2001, Investigative ophthalmology & visual science.

[155]  Younan Xia,et al.  Measuring the Optical Absorption Cross-sections of Au-Ag Nanocages and Au Nanorods by Photoacoustic Imaging. , 2009, The journal of physical chemistry. C, Nanomaterials and interfaces.

[156]  Paul C. Beard,et al.  Pulsed photoacoustic Doppler flowmetry using a cross correlation method , 2010, BiOS.

[157]  M. Gregersen,et al.  THE DISAPPEARANCE OF T-1824 AND STRUCTURALLY RELATED DYES FROM THE BLOOD STREAM , 1943 .

[158]  Ruth A. Rawson,et al.  THE BINDING OF T-1824 AND STRUCTURALLY RELATED DIAZO DYES BY THE PLASMA PROTEINS , 1943 .

[159]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[160]  Lihong V. Wang,et al.  Photoacoustic imaging in biomedicine , 2006 .

[161]  H. Cryer,et al.  Hypoperfusion of the intestinal microcirculation without decreased cardiac output during live Escherichia coli sepsis in rats. , 1989, Circulatory shock.

[162]  Lihong V. Wang,et al.  In vivo volumetric imaging of subcutaneous microvasculature by photoacoustic microscopy. , 2006, Optics express.

[163]  Fanting Kong,et al.  High-resolution photoacoustic imaging of ocular tissues. , 2010, Ultrasound in medicine & biology.

[164]  Lihong V. Wang,et al.  Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue. , 2010, Optics letters.

[165]  B. Amos,et al.  Lessons from the history of light microscopy , 2000, Nature Cell Biology.

[166]  Robert A Kruger,et al.  Photoacoustic angiography of the breast. , 2010, Medical physics.

[167]  A N Smith,et al.  Circulatory and biochemical effects of whole body hyperthermia. , 1975, The British journal of surgery.

[168]  Lihong V. Wang,et al.  Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo , 2012, Nature Medicine.

[169]  Lihong V. Wang,et al.  Simultaneous imaging of a lacZ-marked tumor and microvasculature morphology in vivo by dual-wavelength photoacoustic microscopy. , 2008, Journal of innovative optical health sciences.

[170]  R. Zemp,et al.  Label-free in vivo fiber-based optical-resolution photoacoustic microscopy. , 2011, Optics letters.

[171]  Qifa Zhou,et al.  Real-time four-dimensional optical-resolution photoacoustic microscopy with Au nanoparticle-assisted subdiffraction-limit resolution. , 2011, Optics letters.

[172]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[173]  S A Jones,et al.  Fundamental sources of error and spectral broadening in Doppler ultrasound signals. , 1993, Critical reviews in biomedical engineering.

[174]  John E Tomaszewski,et al.  Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. , 2004, The Journal of clinical investigation.

[175]  Vasilis Ntziachristos,et al.  Real-time imaging of cardiovascular dynamics and circulating gold nanorods with multispectral optoacoustic tomography. , 2010, Optics express.

[176]  Ragnar Olafsson,et al.  Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber. , 2010, Optics express.

[177]  Lihong V. Wang,et al.  Neurovascular Photoacoustic Tomography , 2010, Front. Neuroenerg..

[178]  Fernand Labrie,et al.  Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone. , 2005, The Journal of investigative dermatology.

[179]  R. Bersin,et al.  Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate. , 1994, Journal of the American College of Cardiology.

[180]  Avishay Eyal,et al.  Photoacoustic Doppler measurement of flow using tone burst excitation. , 2010, Optics express.

[181]  A. Calpena,et al.  Skin density in the hairless rat. Evidence of regional differences. , 1991, European journal of drug metabolism and pharmacokinetics.

[182]  J E JESSEPH,et al.  EFFECTS OF PARTIAL RESECTION OF MAMMALIAN SMALL INTESTINE. III. GLUCOSE ABSORPTION, CO2 PRODUCTION AND BLOOD FLOW IN RESIDUAL ILEUM IN THE DOG. , 1963, Review of surgery.

[183]  P. Maquet,et al.  Sleep function(s) and cerebral metabolism , 1995, Behavioural Brain Research.

[184]  A. Oraevsky,et al.  Detection of ultrawide-band ultrasound pulses in optoacoustic tomography , 2003, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[185]  Ruikang K. Wang,et al.  Autocorrelation optical coherence tomography for mapping transverse particle-flow velocity. , 2010, Optics letters.