Application of Time Series Analysis to Serial Blood Neutrophil Counts in Normal Individuals and Patients Receiving Cyclophosphamide

For periods of time ranging from 1 to 3 mth white blood cell and differential counts were made daily on eight normal volunteers and two patients receiving cyclophosphamide. The patients tended to have lower mean neutrophil (PMN) counts than the volunteers; moreover, there was a corresponding decrease in the variability of the counts around the means.

[1]  M. H. Quenouille.  A Large‐Sample Test for the Goodness of Fit of Autoregressive Schemes , 1947 .

[2]  A. Morley,et al.  Cyclic leucocytosis as evidence for retention of normal homoeostatic control in chronic granulocytic leukaemia. , 1967, Lancet.

[3]  M. Kendall.  Statistical Methods for Research Workers , 1937, Nature.

[4]  R. Fisher.  Tests of significance in harmonic analysis , 1929 .

[5]  A. Morley,et al.  Cyclophosphamide-induced cyclical neutropenia. An animal model of a human periodic disease. , 1970, The New England journal of medicine.

[6]  B. Kennedy,et al.  Cyclic leukocyte oscillations in chronic myelogenous leukemia during hydroxyurea therapy. , 1970, Blood.

[7]  Erhan Çinlar,et al.  Introduction to stochastic processes , 1974 .

[8]  E. Ponder,et al.  ON VARIATIONS IN THE WHITE‐CELL COUNT OF MAN , 1931 .

[9]  W. J. Richar,et al.  Evaluation of an electronic particle counter for the counting of white blood cells. , 1959, American journal of clinical pathology.

[10]  A. Morley.  A neutrophil cycle in healthy individuals. , 1966, Lancet.

[11]  H. Hartley,et al.  Tests of significance in harmonic analysis. , 1949, Biometrika.

[12]  A Morley,et al.  Periodic diseases, physiological rhythms and feedback control--a hypothesis. , 1970, Australasian annals of medicine.

[13]  A. Morley,et al.  Erythropoiesis in the Dog: The Periodic Nature of the Steady State , 1969, Science.

[14]  H. Cramér.  Mathematical Methods of Statistics (PMS-9), Volume 9 , 1946 .