High‐dose dietary myo‐inositol supplementation does not alter the ischaemia phenomenon in human diabetics

ABSTRACT Five diabetic patients and 3 non‐diabetics were subjected to a dietary supplement of 20 g per day of myo‐inositol (40 × the normal ingestion) for 14 days. This amount neither produced toxic side‐effects nor changed the peripheral nervefunction expressed by motor conduction velocity or resistance to ischaemia.

[1]  I. Steiness.  Vibratory perception in diabetics during arrested blood flow to the limb. , 2009, Acta medica Scandinavica.

[2]  T. Vilén,et al.  Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy. , 1988, The New England journal of medicine.

[3]  D. Price,et al.  Effect of Aldose Reductase Inhibition on Nerve Conduction Velocity and Resistance to Ischemic Conduction Block in Experimental Diabetes , 1988, Diabetes.

[4]  D. Greene,et al.  Are Disturbances of Sorbitol, Phosphoinositide, and Na+-K+-ATPase Regulation Involved in Pathogenesis of Diabetic Neuropathy? , 1988, Diabetes.

[5]  K. Palmano,et al.  Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes. , 1977, The Biochemical journal.

[6]  D. Greene,et al.  Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes. , 1975, The Journal of clinical investigation.

[7]  G. Gregersen,et al.  THE EFFECT OF ISCHAEMIA ON VIBRATION SENSE IN HYPO‐ OR HYPERCALCAEMIA AND IN DEMYELINATED NERVES , 1971, Acta neurologica Scandinavica.

[8]  K. Seneviratne,et al.  The effects of hypoxia on the excitability of the isolated peripheral nerves of alloxan-diabetic rats. , 1969, Journal of neurology, neurosurgery, and psychiatry.

[9]  G. Gregersen.  A study of the peripheral nerves in diabetic subjects during ischaemia. , 1968, Journal of neurology, neurosurgery, and psychiatry.