Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

[1]  H. Kitaura,et al.  Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb , 2015, Annals of neurology.

[2]  Beth K. Martin,et al.  Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia , 2015, Annals of neurology.

[3]  Seok-Gu Kang,et al.  Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy , 2015, Nature Medicine.

[4]  C. Cepeda,et al.  Basic Mechanisms of Epileptogenesis in Pediatric Cortical Dysplasia , 2015, CNS neuroscience & therapeutics.

[5]  B. Luikart,et al.  Hyperactivity of Newborn Pten Knock-out Neurons Results from Increased Excitatory Synaptic Drive , 2015, The Journal of Neuroscience.

[6]  Jacob M Rosenberg.  Shattuck lecture - A molecular basis for nicotine as a gateway drug , 2014, BDJ.

[7]  S. Danzer,et al.  Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation , 2014, Front. Mol. Neurosci..

[8]  D. Geschwind,et al.  Disentangling the heterogeneity of autism spectrum disorder through genetic findings , 2014, Nature Reviews Neurology.

[9]  H. Schiöth,et al.  Synaptic changes induced by melanocortin signalling , 2014, Nature Reviews Neuroscience.

[10]  Kaustubh Supekar,et al.  Brain hyperconnectivity in children with autism and its links to social deficits. , 2013, Cell reports.

[11]  A. Wilfong,et al.  Treating Epilepsy in Tuberous Sclerosis with Everolimus: Getting Closer , 2014, Epilepsy currents.

[12]  C. Shaw,et al.  Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus. , 2013, European journal of medical genetics.

[13]  A. Galanopoulou.  Basic mechanisms of catastrophic epilepsy – Overview from animal models , 2013, Brain and Development.

[14]  C. Laurent,et al.  Epilepsy in Simplex Autism Pedigrees is Much Lower Than the Rate in Multiplex Autism Pedigrees , 2013, Biological Psychiatry.

[15]  M. Kreek,et al.  Proopiomelanocortin (POMC) expression and conditioned place aversion during protracted withdrawal from chronic intermittent escalating-dose heroin in POMC-EGFP promoter transgenic mice , 2013, Neuroscience.

[16]  P. Bolton,et al.  Neural connectivity abnormalities in autism: Insights from the Tuberous Sclerosis model , 2013, BMC Medicine.

[17]  B. Murphy,et al.  Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy , 2012, Neuron.

[18]  S. Gabriel,et al.  De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly , 2012, Nature Genetics.

[19]  Charles B. Mikell,et al.  The mTOR pathway is activated in glial cells in mesial temporal sclerosis , 2012, Epilepsia.

[20]  S. Padilla,et al.  Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations. , 2012, Endocrinology.

[21]  N. Halfon,et al.  A National Profile of Childhood Epilepsy and Seizure Disorder , 2012, Pediatrics.

[22]  M. Lasaga,et al.  Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP – Protein kinase A pathway , 2012, Molecular and Cellular Endocrinology.

[23]  A. Anderson,et al.  Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS‐Pten conditional knockout mice , 2011, Epilepsia.

[24]  Diana V. Dugas,et al.  Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders , 2011, Science Translational Medicine.

[25]  P. Buckmaster,et al.  Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy , 2011, The Journal of Neuroscience.

[26]  Maria Thom,et al.  The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission 1 , 2011, Epilepsia.

[27]  S. Kochen,et al.  Doublecortin (DCX) immunoreactivity in hippocampus of chronic refractory temporal lobe epilepsy patients with hippocampal sclerosis , 2010, Seizure.

[28]  S. Yoshinari,et al.  Interictal cerebral blood flow abnormality in cryptogenic West syndrome , 2010, Epilepsia.

[29]  G. Mathern.  Challenges in the surgical treatment of epilepsy patients with cortical dysplasia , 2009, Epilepsia.

[30]  P. Crino.  Focal brain malformations: Seizures, signaling, sequencing , 2009, Epilepsia.

[31]  Maria Thom,et al.  Focal cortical dysplasia type II: biological features and clinical perspectives , 2009, The Lancet Neurology.

[32]  A. Anderson,et al.  Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia , 2009, Disease Models & Mechanisms.

[33]  T. Bonhoeffer,et al.  Live-cell imaging of dendritic spines by STED microscopy , 2008, Proceedings of the National Academy of Sciences.

[34]  Mark F. Bear,et al.  The Autistic Neuron: Troubled Translation? , 2008, Cell.

[35]  M. Baulac,et al.  Epilepsy in Autism is Associated with Intellectual Disability and Gender: Evidence from a Meta-Analysis , 2008, Biological Psychiatry.

[36]  H. Shigeto,et al.  Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia , 2008, Epilepsia.

[37]  D. Gutmann,et al.  Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex , 2008, Annals of neurology.

[38]  M. Wilson,et al.  Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network , 2007, Science.

[39]  M. Frotscher,et al.  Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients , 2007, Experimental Neurology.

[40]  J. Swann,et al.  Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia , 2006, Annals of neurology.

[41]  A. Vincent,et al.  Faculty Opinions recommendation of Pten regulates neuronal arborization and social interaction in mice. , 2006 .

[42]  Wei Zhang,et al.  Pten Regulates Neuronal Arborization and Social Interaction in Mice , 2006, Neuron.

[43]  Katsuhiro Kobayashi,et al.  Prevalence of Childhood Epilepsy and Distribution of Epileptic Syndromes: A Population‐based Survey in Okayama, Japan , 2006, Epilepsia.

[44]  J. Eslava-Cobos,et al.  Epilepsy in Colombia: Epidemiologic Profile and Classification of Epileptic Seizures and Syndromes , 2006, Epilepsia.

[45]  C. Cepeda,et al.  Are Cytomegalic Neurons and Balloon Cells Generators of Epileptic Activity in Pediatric Cortical Dysplasia? , 2005, Epilepsia.

[46]  D. D. Fraser,et al.  Systemic Adrenocorticotropic Hormone Administration Down-Regulates the Expression of Corticotropin-Releasing Hormone (CRH) and CRH-Binding Protein in Infant Rat Hippocampus , 2004, Pediatric Research.

[47]  M. Low,et al.  A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus , 2004, The Journal of Neuroscience.

[48]  P. Bolton,et al.  Neuro-epileptic determinants of autism spectrum disorders in tuberous sclerosis complex. , 2002, Brain : a journal of neurology.

[49]  T. Mak,et al.  Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease , 2001, Nature Genetics.

[50]  Masatoshi Ito.  Extremely low-dose ACTH therapy for West syndrome in Japan , 2001, Brain and Development.

[51]  A. Trumpp,et al.  Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo , 2001, Science.

[52]  M. Low,et al.  Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus , 2001, Nature.

[53]  T. Sasaki,et al.  T cell-specific loss of Pten leads to defects in central and peripheral tolerance. , 2001, Immunity.

[54]  K. Christensen,et al.  Genetic and environmental factors in epilepsy: a population-based study of 11 900 Danish twin pairs , 2001, Epilepsy Research.

[55]  B. Neel,et al.  A Role for Nuclear PTEN in Neuronal Differentiation , 2000, The Journal of Neuroscience.

[56]  S. Kyrylenko,et al.  Regulation of PTEN expression in neuronal apoptosis. , 1999, Brain research. Molecular brain research.

[57]  H. Akil,et al.  Diurnal CRH mRNA rhythm in the hypothalamus: decreased expression in the evening is not dependent on endogenous glucocorticoids. , 1993, Neuroendocrinology.

[58]  Tallie A. Baram.  Pathophysiology of massive infantile spasms: Perpective on the putative role of the brain adrenal axis , 1993, Annals of neurology.

[59]  C. Walsh,et al.  Somatic mutations in cerebral cortical malformations. , 2014, The New England journal of medicine.

[60]  H. Shigeto,et al.  fosB-Null Mice Display Impaired Adult Hippocampal Neurogenesis and Spontaneous Epilepsy with Depressive Behavior , 2013, Neuropsychopharmacology.

[61]  T. Baram,et al.  ACTH treatment of infantile spasms: mechanisms of its effects in modulation of neuronal excitability. , 2002, International review of neurobiology.