A portable functional imaging instrument for psychology research based on near-infrared spectroscopy

To aid psychology researches on the function of the prefrontal cortex, a 16-channel brain functional imaging instrument based on near-infrared spectroscopy is developed. The probe of the instrument, covering a detection area of 15 cm × 4.4 cm of the prefrontal cortex, is made flexible and is easy to fix to the forehead. By employing multi-wavelength LEDs as light sources, using integrated detectors and choosing a USB-interface-based data acquisition device, the whole system is portable and convenient to use, which is good for psychological experiments. The system software is developed using Visual C++ 6.0, which controls the imaging process, measurement data plotting and storage. The maximal temporal resolution is about 100 ms. Noise and long-term drift test are given. The Valsalva maneuver experiment is used to validate the reliability of the instrument for monitoring hemodynamic changes.

[1]  D. Newell,et al.  Evaluation of impaired cerebral autoregulation by the Valsalva maneuver. , 1996, Stroke.

[2]  F. Jöbsis.  Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. , 1977, Science.

[3]  B Chance,et al.  Study of an algorithm based on model experiments and diffusion theory for a portable tissue oximeter. , 1997, Journal of biomedical optics.

[4]  B. Chance,et al.  Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager , 2002 .

[5]  D. Boas,et al.  Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging. , 2003, Psychophysiology.

[6]  A. Villringer,et al.  Non-invasive optical spectroscopy and imaging of human brain function , 1997, Trends in Neurosciences.

[7]  J C Hebden,et al.  Time-resolved optical tomography. , 1993, Applied optics.

[8]  R. Haller,et al.  A modular NIRS system for clinical measurement of impaired skeletal muscle oxygenation. , 2000, Journal of applied physiology.

[9]  D. Tank,et al.  Brain magnetic resonance imaging with contrast dependent on blood oxygenation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[10]  D. Heeger,et al.  In this issue , 2002, Nature Reviews Drug Discovery.

[11]  M. Tamura,et al.  Quantitative analysis of hemoglobin oxygenation state of rat brain in situ by near-infrared spectrophotometry. , 1988, Journal of applied physiology.

[12]  H. Steinmetz,et al.  Craniocerebral topography within the international 10-20 system. , 1989, Electroencephalography and clinical neurophysiology.

[13]  Britton Chance,et al.  Precision localization of hidden absorbers in body tissues with phased-array optical systems , 1996 .

[14]  Eric A Newman,et al.  Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling , 2006, The Journal of Neuroscience.

[15]  V. Altuzar,et al.  Atmospheric pollution profiles in Mexico City in two different seasons , 2003 .