Analytical treatment of pattern formation in the Gierer-Meinhardt model of morphogenesis

SummaryWe first perform a linear stability analysis of the Gierer-Meinhardt model to determine the critical parameters where the homogeneous distribution of activator and inhibitor concentrations becomes unstable. There are two kinds of instabilities, namely, one leading to spatial patterns and another one leading to temporal oscillations. Focussing our attention on spatial pattern formation we solve the corresponding nonlinear equations by means of our previously introduced method of generalized Ginzburg-Landau equations. We explicitly consider the two-dimensional case and find both rolls and hexagon-like structures. The impact of different boundary conditions on the resulting patterns is also discussed. The occurrence of the new patterns has all the features of nonequilibrium phase transitions.

[1]  A. Turing The chemical basis of morphogenesis , 1952, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[2]  Friedrich H. Busse,et al.  The stability of finite amplitude cellular convection and its relation to an extremum principle , 1967, Journal of Fluid Mechanics.

[3]  John Whitehead,et al.  Finite bandwidth, finite amplitude convection , 1969, Journal of Fluid Mechanics.

[4]  Friedrich H. Busse,et al.  Thermal instabilities in rapidly rotating systems , 1970, Journal of Fluid Mechanics.

[5]  Lee A. Segel,et al.  Non-linear wave-number interaction in near-critical two-dimensional flows , 1971, Journal of Fluid Mechanics.

[6]  H. Meinhardt,et al.  Applications of a theory of biological pattern formation based on lateral inhibition. , 1974, Journal of cell science.

[7]  A Babloyantz,et al.  Models for cell differentiation and generation of polarity in diffusion-governed morphogenetic fields. , 1975, Bulletin of mathematical biology.

[8]  Bernard J. Matkowsky,et al.  On Boundary Layer Problems Exhibiting Resonance , 1975 .

[9]  H. Haken Higher order corrections to generalized ginzburg-Landau Equations of non-equilibrium systems , 1975 .

[10]  H. Haken Generalized Ginzburg-Landau equations for phase transition-like phenomena in lasers, nonlinear optics, hydrodynamics and chemical reactions , 1975 .

[11]  F. Busse Patterns of convection in spherical shells , 1975, Journal of Fluid Mechanics.

[12]  G. Sell,et al.  The Hopf Bifurcation and Its Applications , 1976 .

[13]  S. Levin Uniqueness theorems for the compressible flow equation , 1976 .

[14]  H. Meinhardt,et al.  The Spatial Control of Cell Differentiation by Autocatalysis and Lateral Inhibition , 1977 .

[15]  M. Granero,et al.  A bifurcation analysis of pattern formation in a diffusion governed morphogenetic field , 1977, Journal of mathematical biology.

[16]  Cooperative Effects in Fluid Problems , 1977 .

[17]  H. Haken Synergetics: an Introduction, Nonequilibrium Phase Transitions and Self-organization in Physics, Chemistry, and Biology , 1977 .

[18]  T. J. Mahar,et al.  A Model Biochemical Reaction Exhibiting Secondary Bifurcation , 1977 .