Sublingual spray: a new technology oriented formulation with multiple benefits

Sublingual drug delivery system was a well-established platform for delivering the drug that need to exhibit quick actionwithout any irst-passmetabolic effect, but various pitfall in the regular sublingual drug delivery systems such as a tablet, capsule etc., that can be overcome by novel sublingual drug delivery technology such as particulate sublingual spray. Sublingual spray for drug administration has gained attention in the market since it proved its propensity to by-pass the irst-pass metabolism and to initiate a rapid onset of action due to its atomizedmicro particulate nature, which is signi icantly higher than the other sublingual formulations. The approval of sublingual spray by the regulatory agencies may commence further research in this ield by subsuming various essential drugs for indications such as cancer pain, cardiovascular issue etc. This article comprises a detailed study on the drawback of conventional sublingual drug delivery system and the approach by which these drawbacks can be overruled by spray technology in the sublingual area and the, in-depth mechanism of drug delivery through sublingual with the help of atomization followed by the entire formulation strategy alongwith evaluation and industrial perspective of the sublingual spray dosage form as a future tool of patient-friendly drug delivery.

[1]  H. Boddé,et al.  Methods for assessing the buccal mucosa as a route of drug delivery , 1993 .

[2]  P. Wertz,et al.  Organization, barrier function and antimicrobial lipids of the oral mucosa , 2013, International journal of cosmetic science.

[3]  R. Shangraw,et al.  PREPARATION AND STABILITY OF GLYCERYL TRINITRATE SUBLINGUAL TABLETS PREPARED BY DIRECT COMPRESSION. , 1965, Journal of pharmaceutical sciences.

[4]  M. Picardo,et al.  The structure and function of oral mucosa. , 1991, Dental update.

[5]  K. L. Moore,et al.  Clinically Oriented Anatomy , 1985 .

[6]  P. Saha,et al.  SUBLINGUAL DRUG DELIVERY: AN INDICATION OF POTENTIAL ALTERNATIVE ROUTE , 2017 .

[7]  J. Kaski,et al.  Vasodilator Therapy: Nitrates and Nicorandil , 2016, Cardiovascular Drugs and Therapy.

[8]  V. Pokharkar,et al.  Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles. , 2017 .

[9]  F. C. Holsinger,et al.  Anatomy, Function, and Evaluation of the Salivary Glands , 2007 .

[10]  K. Patel,et al.  Buccal Mucosa as A Route for Systemic Drug Delivery: A Review , 2012 .

[11]  Hellen Adams,et al.  Patent and Trademark Office , 2017 .

[12]  T. Davis,et al.  Pharmacokinetics of a Novel Sublingual Spray Formulation of the Antimalarial Drug Artemether in Healthy Adults , 2015, Antimicrobial Agents and Chemotherapy.

[13]  D. Luscombe,et al.  Pharmacokinetics and pharmacodynamics of verapamil following sublingual and oral administration to healthy volunteers. , 1992, British Journal of Clinical Pharmacology.

[14]  D. Breimer,et al.  Drug absorption by sublingual and rectal routes. , 1984, British journal of anaesthesia.

[15]  J. McElnay,et al.  The effect of pH on the buccal and sublingual absorption of captopril , 2004, European Journal of Clinical Pharmacology.

[16]  Preeta Caroline,et al.  Sublingual Tablets and the Benefits of the Sublingual Route of Administration , 2017 .

[17]  A Vissink,et al.  The functions of human saliva: A review sponsored by the World Workshop on Oral Medicine VI. , 2015, Archives of oral biology.

[18]  P. Wertz,et al.  STRUCTURE AND FUNCTION OF THE ORAL MUCOSA AND IMPLICATIONS FOR DRUG DELIVERY , 1996 .

[19]  B. Anson,et al.  Surgical anatomy of the facial nerve and parotid gland based upon a study of 350 cervicofacial halves. , 1956, Surgery, gynecology & obstetrics.

[20]  R. Ferrari,et al.  Treatment of Angina: Where Are We? , 2018, Cardiology.

[21]  P. Kothiyal,et al.  Sublingual tablets: an overview , 2016 .

[22]  W. Hollinshead.  Anatomy for surgeons. , 1969 .

[23]  Donald R. Taylor,et al.  Single-dose fentanyl sublingual spray for breakthrough cancer pain , 2013, Clinical pharmacology : advances and applications.

[24]  P. Treuting,et al.  Comparative Anatomy and Histology , 2012 .

[25]  Abeer M. Al-Ghananeem,et al.  Sublingual spray drug delivery of ketorolac-loaded chitosan nanoparticles , 2018, Drug development and industrial pharmacy.