Embedded Unit for Point-of-Care Impedance Based Biosensor Readout

Bridging the gap between state of the art consumer electronics and bio-analytical setups designed for lab environments, an embedded, miniaturised, stand-alone measurement device is developed. The presented impedance analyser incorporates most of the data communication features present in current-generation smartphones and is specifically optimised for low-frequency impedance based biosensor readout. The compact unit operates fully stand-alone with a touchscreen. Its functionality was tested and verified. In this work the unit is tested by using a biomimetic sensing device for the detection of L-nicotine. The combination between the handheld, embedded design of this specialised measurement equipment and a sensor layout fine-tuned for specific applications could mean significant advances in point-of-care systems.

[1]  Anne Marie Piper,et al.  Supporting medical communication for older patients with a shared touch-screen computer , 2013, Int. J. Medical Informatics.

[2]  Rajkumar Buyya,et al.  An autonomic cloud environment for hosting ECG data analysis services , 2012, Future Gener. Comput. Syst..

[3]  Nicholas A Peppas,et al.  Critical review and perspective of macromolecularly imprinted polymers. , 2012, Acta biomaterialia.

[4]  M vandeVen,et al.  A MIP-based impedimetric sensor for the detection of low-MW molecules. , 2008, Biosensors & bioelectronics.

[5]  Eun-Hyun Lee,et al.  Touch-Screen Computerized Quality-of-Life Assessment for Patients with Cancer. , 2009, Asian nursing research.

[6]  John O'Mahony,et al.  Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003 , 2006, Journal of molecular recognition : JMR.

[7]  N. V. D. Weghe,et al.  The use of Bluetooth for analysing spatiotemporal dynamics of human movement at mass events: a case study of the Ghent Festivities. , 2012 .

[8]  Chen-Khong Tham,et al.  Experiences on developing SOA based mobile healthcare services , 2009, 2009 IEEE Asia-Pacific Services Computing Conference (APSCC).

[9]  Nicole Jaffrezic-Renault,et al.  Molecularly imprinted polymers (MIP) based electrochemical sensor for detection of urea and creatinine , 2010 .

[10]  Ward De Ceuninck,et al.  Customized impedance spectroscopy device as possible sensor platform for biosensor applications , 2010 .

[11]  Wlodzimierz Kutner,et al.  Molecularly imprinted polymer (MIP) based piezoelectric microgravimetry chemosensor for selective determination of adenine. , 2010, Biosensors & bioelectronics.

[12]  L Michiels,et al.  Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation. , 2011, Lab on a chip.

[13]  M vandeVen,et al.  Impedimetric immunosensors based on the conjugated polymer PPV. , 2005, Biosensors & bioelectronics.

[14]  Evi Bongaers,et al.  MIP-based sensor platforms for the detection of histamine in the nano- and micromolar range in aqueous media , 2010 .

[15]  Sie Boo Chiang,et al.  Ultra low power SOC for portable health monitoring platforms , 2011, 2011 International Symposium on Integrated Circuits.

[16]  Marloes Peeters,et al.  Miniaturised eight‐channel impedance spectroscopy unit as sensor platform for biosensor applications , 2011 .

[17]  P. St-Louis.  Status of point-of-care testing: promise, realities, and possibilities. , 2000, Clinical biochemistry.

[18]  Manoj Kumar,et al.  Screening for psychological distress in palliative care: performance of touch screen questionnaires compared with semistructured psychiatric interview. , 2009, Journal of pain and symptom management.

[19]  Laurence Lutsen,et al.  A MIP‐based biomimetic sensor for the impedimetric detection of histamine in different pH environments , 2010 .

[20]  Seok-Jun Lee,et al.  Microwatt Embedded Processor Platform for Medical System-on-Chip Applications , 2011, IEEE Journal of Solid-State Circuits.

[21]  Sourabh Ravindran,et al.  Low complexity algorithms for heart rate and epileptic seizure detection , 2009, 2009 2nd International Symposium on Applied Sciences in Biomedical and Communication Technologies.

[22]  Joseph Yiu,et al.  The definitive guide to the ARM Cortex-M3 , 2007 .

[23]  Fan-Ching Chien,et al.  A microfluidic chip integrated with molecular imprinting polymer for surface plasmon resonance detection , 2005, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05..

[24]  Ken Haenen,et al.  Heat-transfer resistance at solid-liquid interfaces: a tool for the detection of single-nucleotide polymorphisms in DNA. , 2012, ACS nano.

[25]  Ward De Ceuninck,et al.  Development of multichannel quartz crystal microbalances for MIP‐based biosensing , 2012 .

[26]  F. Navarro-Villoslada,et al.  Molecularly imprinted polymer diffraction grating as label-free optical bio(mimetic)sensor. , 2011, Biosensors & bioelectronics.