Mechanistic model to predict colostrum intake based on deuterium oxide dilution technique data and impact of gestation and prefarrowing diets on piglet intake and sow yield of colostrum.

The aims of the present study were to quantify colostrum intake (CI) of piglets using the D2O dilution technique, to develop a mechanistic model to predict CI, to compare these data with CI predicted by a previous empirical predictive model developed for bottle-fed piglets, and to study how composition of diets fed to gestating sows affected piglet CI, sow colostrum yield (CY), and colostrum composition. In total, 240 piglets from 40 litters were enriched with D2O. The CI measured by D2O from birth until 24 h after the birth of first-born piglet was on average 443 g (SD 151). Based on measured CI, a mechanistic model to predict CI was developed using piglet characteristics (24-h weight gain [WG; g], BW at birth [BWB; kg], and duration of CI [D; min]: CI, g=-106+2.26 WG+200 BWB+0.111 D-1,414 WG/D+0.0182 WG/BWB (R2=0.944). This model was used to predict the CI for all colostrum suckling piglets within the 40 litters (n=500, mean=437 g, SD=153 g) and was compared with the CI predicted by a previous empirical predictive model (mean=305 g, SD=140 g). The previous empirical model underestimated the CI by 30% compared with that obtained by the new mechanistic model. The sows were fed 1 of 4 gestation diets (n=10 per diet) based on different fiber sources (low fiber [17%] or potato pulp, pectin residue, or sugarbeet pulp [32 to 40%]) from mating until d 108 of gestation. From d 108 of gestation until parturition, sows were fed 1 of 5 prefarrowing diets (n=8 per diet) varying in supplemented fat (3% animal fat, 8% coconut oil, 8% sunflower oil, 8% fish oil, or 4% fish oil+4% octanoic acid). Sows fed diets with pectin residue or sugarbeet pulp during gestation produced colostrum with lower protein, fat, DM, and energy concentrations and higher lactose concentrations, and their piglets had greater CI as compared with sows fed potato pulp or the low-fiber diet (P<0.05), and sows fed pectin residue had a greater CY than potato pulp-fed sows (P<0.05). Prefarrowing diets affected neither CI nor CY, but the prefarrowing diet with coconut oil decreased lactose and increased DM concentrations of colostrum compared with other prefarrowing diets (P<0.05). In conclusion, the new mechanistic predictive model for CI suggests that the previous empirical predictive model underestimates CI of sow-reared piglets by 30%. It was also concluded that nutrition of sows during gestation affected CY and colostrum composition.

[1]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.

[2]  W. Horwitz.  Official Methods of Analysis , 1980 .

[3]  S. Rotenberg,et al.  The Effect of Dietary Citrus Pectin on Fatty Acid Balance and on the Fatty Acid Content of the Liver and Small Intestine in Rats , 1980 .

[4]  J. Noblet,et al.  Energy metabolism of the newborn pig during the first 24 h or life. , 1981, Biology of the neonate.

[5]  J. Pettigrew.  SUPPLEMENTAL DIETARY FAT FOR PERIPARTAL SOWS: A REVIEW' , 1981 .

[6]  J. Pettigrew,et al.  A refinement and evaluation of the isotope dilution method for estimating milk intake by piglets , 1987 .

[7]  B. Hansen.  Determination of nitrogen as elementary N, an alternative to Kjeldahl. , 1989 .

[8]  J. Rushen,et al.  Suckling and teat disputes by neonatal piglets , 1989 .

[9]  J. N. R. Jeffers,et al.  Graphical Models in Applied Multivariate Statistics. , 1990 .

[10]  A. H. Jensen,et al.  Effects of induced or delayed parturition and supplemental dietary fat on colostrum and milk composition in sows. , 1995, Journal of animal science.

[11]  K. Knudsen.  Carbohydrate and lignin contents of plant materials used in animal feeding , 1997 .

[12]  J. Speakman,et al.  Doubly Labelled Water: Theory and Practice , 1997 .

[13]  J. Dourmad,et al.  Energy metabolism in pregnant sows and newborn pigs. , 1997, Journal of animal science.

[14]  P. Herpin,et al.  Effect of fat content of colostrum on voluntary colostrum intake and fat utilization in newborn pigs. , 1997, Journal of animal science.

[15]  D. Bates,et al.  Mixed-Effects Models in S and S-PLUS , 2001 .

[16]  N. Kristensen,et al.  Energy intake and milk production in mink (MUSTELA vison)‐effect of litter size , 2001, Archiv fur Tierernahrung.

[17]  T. T. Nielsen,et al.  Estimation of Milk Production in Lactating Sows by Determination of Deuterated Water Turnover in Three Piglets per Litter , 2002 .

[18]  T. Cole,et al.  Water turnover and the measurement of milk intake , 2004, Pflügers Archiv.

[19]  Charlotte Lauridsen,et al.  Lactational dietary fat levels and sources influence milk composition and performance of sows and their progeny , 2004 .

[20]  A. Prunier,et al.  Estimation of colostrum intake in the neonatal pig , 2004 .

[21]  P. Herpin,et al.  Nutritional and immunological importance of colostrum for the new-born pig , 2005, The Journal of Agricultural Science.

[22]  J. Le Dividich,et al.  Variability of colostrum yield and colostrum intake in pigs. , 2007, Animal : an international journal of animal bioscience.

[23]  P. Theil,et al.  Milk intake and carbon dioxide production of piglets determined with the doubly labelled water technique. , 2007, Animal : an international journal of animal bioscience.

[24]  David Edwards,et al.  High-dimensional Graphical Model Search with gRapHD R Package , 2009, 0909.1234.

[25]  Gabriel C. G. de Abreu,et al.  Characterization of differentially expressed genes using high-dimensional co-expression networks , 2010, 1011.3805.

[26]  P. Theil,et al.  Effects of gestation and transition diets, piglet birth weight, and fasting time on depletion of glycogen pools in liver and 3 muscles of newborn piglets. , 2011, Journal of animal science.

[27]  P. Theil,et al.  Effects of nutrient supply, plasma metabolites, and nutritional status of sows during transition on performance in the next lactation. , 2012, Journal of animal science.

[28]  P. Theil,et al.  Feeding motivation and plasma metabolites in pregnant sows fed diets rich in dietary fiber either once or twice daily. , 2012, Journal of animal science.

[29]  N. Devillers,et al.  Colostrum intake: Influence on piglet performance and factors of variation , 2012 .

[30]  P. Theil,et al.  Colostrum and milk production of sows is affected by dietary conjugated linoleic acid. , 2012, Journal of animal science.

[31]  Effect of β-hydroxy β-methyl butyrate supplementation of sows in late gestation and lactation on sow production of colostrum and milk and piglet performance. , 2012, Journal of animal science.

[32]  P. Theil,et al.  Intrauterine growth restricted piglets defined by their head shape ingest insufficient amounts of colostrum. , 2013, Journal of animal science.

[33]  P. Ramaekers,et al.  Effects of high fiber intake during late pregnancy on sow physiology, colostrum production, and piglet performance. , 2013, Journal of animal science.

[34]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .