Cerebrovascular Reserve: The Link Between Fitness and Cognitive Function?

Better physical fitness in later life is associated positively with cognitive functioning. Novel data suggest that this association is mediated, in part, by increases in brain perfusion and the ability of cerebral blood vessels to respond to demand. This review presents evidence on the beneficial effects of exercise on cerebrovascular and cognitive health with aging and explores potential underlying vascular-related mechanisms.

[1]  Janet B W Williams,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[2]  M. Poulin,et al.  Effects of the nitric oxide synthase inhibitor L‐NMMA on cerebrovascular and cardiovascular responses to hypoxia and hypercapnia in humans , 2007, Journal of Physiology.

[3]  D. Seals,et al.  Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down‐regulation of NADPH oxidase , 2009, The Journal of physiology.

[4]  Greg Atkinson,et al.  Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing , 2008, The Journal of physiology.

[5]  Catherine Gondry-Jouet,et al.  Aging Effects on Cerebral Blood and Cerebrospinal Fluid Flows , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[6]  Vanessa Sluming,et al.  Calibrated fMRI during a cognitive Stroop task reveals reduced metabolic response with increasing age , 2012, NeuroImage.

[7]  L. Celi,et al.  Effects of Age and Coronary Artery Disease on Cerebrovascular Reactivity to Carbon Dioxide in Humans , 2010, Anaesthesia and intensive care.

[8]  C. Friedenreich,et al.  Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women , 2010, Neurobiology of Aging.

[9]  T. Manini,et al.  Activity energy expenditure and incident cognitive impairment in older adults. , 2011, Archives of internal medicine.

[10]  B. Thompson,et al.  Nitric oxide mediation of chemoregulation but not autoregulation of cerebral blood flow in primates. , 1996, Journal of neurosurgery.

[11]  M. Albert,et al.  Predictors of cognitive change in older persons: MacArthur studies of successful aging. , 1995, Psychology and aging.

[12]  B. Winblad,et al.  Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease , 2005, The Lancet Neurology.

[13]  T. Salthouse Selective review of cognitive aging , 2010, Journal of the International Neuropsychological Society.

[14]  A. Kramer,et al.  Fitness Effects on the Cognitive Function of Older Adults , 2003, Psychological science.

[15]  S. Rubin,et al.  Predictors of maintaining cognitive function in older adults , 2009, Neurology.

[16]  Martin R. Lindley,et al.  The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease , 2011, Nature Reviews Immunology.

[17]  C. Craig,et al.  Physical activity of Canadian adults: accelerometer results from the 2007 to 2009 Canadian Health Measures Survey. , 2011, Health reports.

[18]  E. Hamel Perivascular nerves and the regulation of cerebrovascular tone. , 2006, Journal of applied physiology.

[19]  Zhe Ying,et al.  Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition , 2004, The European journal of neuroscience.

[20]  Jeffrey N. Browndyke,et al.  Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials , 2010, Psychosomatic medicine.

[21]  M. Mattson,et al.  Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. , 2003, Developmental biology.

[22]  Arthur F. Kramer,et al.  Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function , 2007, Trends in Cognitive Sciences.

[23]  Paige E. Scalf,et al.  Aerobic exercise training increases brain volume in aging humans. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[24]  R. de Cabo,et al.  Mechanisms of vascular aging: new perspectives. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[25]  Richard P. White,et al.  Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia. , 1998, Stroke.

[26]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[27]  A. Kramer,et al.  Be smart, exercise your heart: exercise effects on brain and cognition , 2008, Nature Reviews Neuroscience.

[28]  M. Endres,et al.  Mechanisms of stroke protection by physical activity , 2003, Annals of neurology.

[29]  C. Friedenreich,et al.  Effect of Cardiorespiratory Fitness on Vascular Regulation and Oxidative Stress in Postmenopausal Women , 2009, Hypertension.

[30]  H. D. Morris,et al.  Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat , 2003, Neuroscience.

[31]  Diana Gaitini,et al.  Impaired cerebral CO2 vasoreactivity: association with endothelial dysfunction. , 2006, American journal of physiology. Heart and circulatory physiology.

[32]  K Yaffe,et al.  A prospective study of physical activity and cognitive decline in elderly women: women who walk. , 2001, Archives of internal medicine.

[33]  J. Manson,et al.  Physical activity and cognition in women with vascular conditions. , 2011, Archives of internal medicine.

[34]  Carl W. Cotman,et al.  Exercise builds brain health: key roles of growth factor cascades and inflammation , 2007, Trends in Neurosciences.

[35]  Eng H. Lo,et al.  The Science of Stroke: Mechanisms in Search of Treatments , 2010, Neuron.

[36]  D. Attwell,et al.  Glial and neuronal control of brain blood flow , 2022 .

[37]  M. Hamer,et al.  Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence , 2008, Psychological Medicine.

[38]  C. Iadecola Neurovascular regulation in the normal brain and in Alzheimer's disease , 2004, Nature Reviews Neuroscience.

[39]  M. Poulin,et al.  Frontiers in Aging Neuroscience Aging Neuroscience , 2022 .

[40]  E. McAuley,et al.  Exercise training increases size of hippocampus and improves memory , 2011, Proceedings of the National Academy of Sciences.

[41]  R. Shephard Physical activity of Canadian adults: Accelerometer results from the 2007 to 2009 Canadian Health Measures Survey , 2011 .

[42]  M. Hennerici,et al.  Age and stimulus dependency of visually evoked cerebral blood flow responses. , 1999, Stroke.