Wind of Change Challenges Toxicological Regulators
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Andreas Luch | Manfred Liebsch | Christian Riebeling | Andrea Seiler | Tewes Tralau | A. Luch | M. Oelgeschläger | A. Seiler | T. Tralau | C. Riebeling | R. Pirow | Michael Oelgeschläger | Ralph Pirow | M. Liebsch | M. Oelgeschläger
[1] Andreas Luch,et al. Drug-mediated toxicity: illuminating the 'bad' in the test tube by means of cellular assays? , 2012, Trends in pharmacological sciences.
[2] L. Kuepfer,et al. Using Expression Data for Quantification of Active Processes in Physiologically Based Pharmacokinetic Modeling , 2012, Drug Metabolism and Disposition.
[3] O. Lee,et al. Rapid generation of mature hepatocyte‐like cells from human induced pluripotent stem cells by an efficient three‐step protocol , 2012, Hepatology.
[4] Laurent Griscom,et al. Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. , 2012, Toxicology and applied pharmacology.
[5] A. Bader,et al. Three dimensional cultures of rat liver cells using a natural self‐assembling nanoscaffold in a clinically relevant bioreactor for bioartificial liver construction , 2012, Journal of cellular physiology.
[6] D J Dix,et al. Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics. , 2011, Toxicology and applied pharmacology.
[7] Scott M. Auerbach,et al. Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.
[8] A. Kamburov,et al. Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity , 2011, Toxicological sciences : an official journal of the Society of Toxicology.
[9] Ivan Rusyn,et al. Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches. , 2011, Chemical research in toxicology.
[10] A. Piersma,et al. Developmental immunotoxicity of di-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study. , 2011, Toxicology letters.
[11] Mandy B. Esch,et al. The role of body-on-a-chip devices in drug and toxicity studies. , 2011, Annual review of biomedical engineering.
[12] Weida Tong,et al. Comparative analysis of predictive models for nongenotoxic hepatocarcinogenicity using both toxicogenomics and quantitative structure-activity relationships. , 2011, Chemical research in toxicology.
[13] David M. Reif,et al. Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay , 2011, PloS one.
[14] Andrea E M Seiler,et al. The validated embryonic stem cell test to predict embryotoxicity in vitro , 2011, Nature Protocols.
[15] Jan G. Hengstler,et al. A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing , 2011, Archives of Toxicology.
[16] Andreas Luch,et al. Alternatives to animal testing: current status and future perspectives , 2011, Archives of Toxicology.
[17] Valérie Zuang,et al. Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010 , 2011, Archives of Toxicology.
[18] E. Fabian,et al. Chemical toxicity testing in vitro using cytochrome P450–expressing cell lines, such as human CYP1B1 , 2011, Nature Protocols.
[19] W. Koh,et al. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing , 2011, Cell Death and Differentiation.
[20] H. Wichterle,et al. Programming embryonic stem cells to neuronal subtypes , 2011, Current Opinion in Neurobiology.
[21] A. Wobus,et al. Present state and future perspectives of using pluripotent stem cells in toxicology research , 2011, Archives of Toxicology.
[22] D. Rancourt,et al. Comparing three novel endpoints for developmental osteotoxicity in the embryonic stem cell test. , 2010, Toxicology and applied pharmacology.
[23] J C Madden,et al. Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity. , 2010, Reproductive toxicology.
[24] Hilda Witters,et al. The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants. , 2010, Reproductive toxicology.
[25] M. Ott,et al. Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing. , 2010, Reproductive toxicology.
[26] D. Hay,et al. Role of stem-cell-derived hepatic endoderm in human drug discovery. , 2010, Biochemical Society transactions.
[27] Uwe Marx,et al. Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure. , 2010, Journal of biotechnology.
[28] D. Ingber,et al. Reconstituting Organ-Level Lung Functions on a Chip , 2010, Science.
[29] D. Dix,et al. Computational Toxicology as Implemented by the U.S. EPA: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard and Risk , 2010, Journal of toxicology and environmental health. Part B, Critical reviews.
[30] J. Bailar,et al. Toxicity Testing in the 21st Century: A Vision and a Strategy , 2010, Journal of toxicology and environmental health. Part B, Critical reviews.
[31] J. Dorne,et al. Metabolism, variability and risk assessment. , 2010, Toxicology.
[32] David M. Reif,et al. In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project , 2009, Environmental health perspectives.
[33] A. Sachinidis,et al. The potential of embryonic stem cells combined with -omics technologies as model systems for toxicology. , 2009, Current medicinal chemistry.
[34] T. Hartung. Toxicology for the twenty-first century , 2009, Nature.
[35] James S MacDonald,et al. Toxicity testing in the 21st century: a view from the pharmaceutical industry. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.
[36] Francesco Pampaloni,et al. Three-Dimensional Cell Cultures in Toxicology , 2009, Biotechnology & genetic engineering reviews.
[37] Rajeev Kumar,et al. A systems biology based integrative framework to enhance the predictivity of in vitro methods for drug-induced liver injury , 2008, Expert opinion on drug safety.
[38] Nathalie Delrue,et al. A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426 , 2008, Environmental health perspectives.
[39] F. Collins,et al. Transforming Environmental Health Protection , 2008, Science.
[40] R. Feil,et al. Epigenetic stability of embryonic stem cells and developmental potential. , 2007, Trends in biotechnology.
[41] M. Rao,et al. The therapeutic potential of embryonic stem cells: A focus on stem cell stability. , 2006, Current opinion in molecular therapeutics.
[42] Susanne Bremer,et al. Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests , 2004, Alternatives to laboratory animals : ATLA.
[43] J. Dorne,et al. Uncertainty factors for chemical risk assessment: interspecies differences in glucuronidation. , 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[44] J M Collins,et al. Extrapolation of animal toxicity to humans: interspecies comparisons in drug development. , 1990, Regulatory toxicology and pharmacology : RTP.
[45] S. Kharb. Toxicology , 1936 .
[46] In Vitro. OECD GUIDELINES FOR THE TESTING OF CHEMICALS In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method , 2013 .
[47] S. Hongeng,et al. Development of immortalized hepatocyte-like cells from hMSCs. , 2012, Methods in molecular biology.
[48] Takao Hayakawa,et al. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.
[49] M. Shuler,et al. In vitro microscale systems for systematic drug toxicity study , 2010, Bioprocess and biosystems engineering.
[50] C. Rovida,et al. Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the transatlantic think tank for toxicology (t(4)). , 2009, ALTEX.
[51] Roberto Binetti,et al. Exponential growth of new chemicals and evolution of information relevant to risk control. , 2008, Annali dell'Istituto superiore di sanita.
[52] OECD GUIDELINES FOR THE TESTING OF CHEMICALS , 2008 .
[53] D. Dix,et al. The ToxCast program for prioritizing toxicity testing of environmental chemicals. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.
[54] Manfred Fleischer,et al. Testing Costs and Testing Capacity According to the REACH Requirements - Results of a Survey of Independent and Corporate GLP Laboratories in the EU and Switzerland , 2007 .
[55] Yudong D. He,et al. Development of an approach for ab initio estimation of compound-induced liver injury based on global gene transcriptional profiles. , 2006, Genome informatics. International Conference on Genome Informatics.
[56] C. Eskes,et al. Alternative (non-Animal) Methods for Cosmetics Testing : Current Status and Future Prospects. A Report Prepared in the Context of the 7th Amendment to the Cosmetics Directive for Establishing the Timetable for Phasing Out Animal Testing , 2005 .
[57] H. Spielmann,et al. Cytotoxicity test using blastocyst-derived euploid embryonal stem cells: a new approach to in vitro teratogenesis screening. , 1991, Reproductive toxicology.
[58] K. Keller,et al. Potential human developmental toxicants and the role of animal testing in their identification and characterization. , 1989, Critical reviews in toxicology.
[59] L. Wolpert. Developmental Biology , 1968, Nature.