The who, how and where of antigen presentation to B cells

[1]  F. Klauschen,et al.  SAP-controlled T-B cell interactions underlie germinal centre formation , 2008, Nature.

[2]  Burkhard Ludewig,et al.  Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence , 2008, Nature Reviews Immunology.

[3]  P. Ongusaha,et al.  Prolyl 4-hydroxylation regulates Argonaute 2 stability , 2008, Nature.

[4]  S. Pierce,et al.  Membrane heterogeneities in the formation of B cell receptor–Lyn kinase microclusters and the immune synapse , 2008, The Journal of cell biology.

[5]  Magdalini Moutaftsi,et al.  Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. , 2008, Immunity.

[6]  B. Heyman,et al.  A Novel B Cell-Mediated Transport of IgE-Immune Complexes to the Follicle of the Spleen1 , 2008, The Journal of Immunology.

[7]  B. Treanor,et al.  Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen , 2008, The Journal of experimental medicine.

[8]  M. Cahalan,et al.  Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. , 2008, Annual review of immunology.

[9]  M. Ishii,et al.  Making friends in out‐of‐the‐way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging , 2008, Immunological reviews.

[10]  J. Cyster,et al.  Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. , 2008, Seminars in immunology.

[11]  P. Bousso,et al.  Decoding the dynamics of T cell–dendritic cell interactions in vivo , 2008, Immunological reviews.

[12]  M. Bajénoff,et al.  Seeing is believing: A focus on the contribution of microscopic imaging to our understanding of immune system function , 2007, European journal of immunology.

[13]  N. D. Di Paolo,et al.  Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells , 2007, Nature.

[14]  T. Phan,et al.  Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells , 2007, Nature Immunology.

[15]  I. MacLennan Holding antigen where B cells can find it , 2007, Nature Immunology.

[16]  F. Batista,et al.  B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. , 2007, Immunity.

[17]  Anja E Hauser,et al.  Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. , 2007, Immunity.

[18]  M. Jenkins,et al.  The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. , 2007, Immunity.

[19]  Michael L. Dustin,et al.  In vivo imaging of germinal centres reveals a dynamic open structure , 2007, Nature.

[20]  Jason G. Cyster,et al.  Imaging of Germinal Center Selection Events During Affinity Maturation , 2007, Science.

[21]  R. Steinman,et al.  Differential Antigen Processing by Dendritic Cell Subsets in Vivo , 2007, Science.

[22]  Ronald N Germain,et al.  Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. , 2006, Immunity.

[23]  Ian Parker,et al.  Imaging the choreography of lymphocyte trafficking and the immune response. , 2006, Current opinion in immunology.

[24]  M. Cesta Normal Structure, Function, and Histology of the Spleen , 2006, Toxicologic pathology.

[25]  Michael L. Dustin,et al.  Dynamic imaging of the immune system: progress, pitfalls and promise , 2006, Nature Reviews Immunology.

[26]  Ronald N. Germain,et al.  Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells , 2006, Science.

[27]  F. Batista,et al.  B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands. , 2006, Current opinion in immunology.

[28]  J. Goldman,et al.  B Cell Ligand Discrimination Through a Spreading and Contraction Response , 2006, Science.

[29]  Shannon M. Anderson,et al.  Cutting Edge: Memory B Cell Survival and Function in the Absence of Secreted Antibody and Immune Complexes on Follicular Dendritic Cells1 , 2006, The Journal of Immunology.

[30]  D. Gray,et al.  Primary T Cell Expansion and Differentiation In Vivo Requires Antigen Presentation by B Cells1 , 2006, The Journal of Immunology.

[31]  N. Huang,et al.  B Cells Productively Engage Soluble Antigen-Pulsed Dendritic Cells: Visualization of Live-Cell Dynamics of B Cell-Dendritic Cell Interactions , 2005, The Journal of Immunology.

[32]  Takashi Saito,et al.  Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76 , 2005, Nature Immunology.

[33]  R. Clynes,et al.  Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. , 2005, Immunity.

[34]  Michael Loran Dustin,et al.  Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling , 2005, The Journal of experimental medicine.

[35]  C. Halin,et al.  In vivo imaging of lymphocyte trafficking. , 2005, Annual review of cell and developmental biology.

[36]  T. van der Poll,et al.  Specific ICAM‐3 grabbing nonintegrin‐related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection , 2005, European journal of immunology.

[37]  J. Kearney,et al.  Marginal zone B cells in lymphocyte activation and regulation. , 2005, Current opinion in immunology.

[38]  Mark J. Miller,et al.  Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells , 2005, PLoS biology.

[39]  Henry C. Chang,et al.  Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate , 2005, Science.

[40]  Randall L. Lindquist,et al.  Visualizing dendritic cell networks in vivo , 2004, Nature Immunology.

[41]  R. Corley,et al.  Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells. , 2004, International immunology.

[42]  Marc K Jenkins,et al.  Visualizing the first 50 hr of the primary immune response to a soluble antigen. , 2004, Immunity.

[43]  Philippe Bousso,et al.  Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy. , 2004, Immunity.

[44]  M. Lindorfer,et al.  Analyses of the In Vivo Trafficking of Stoichiometric Doses of an Anti-Complement Receptor 1/2 Monoclonal Antibody Infused Intravenously in Mice1 , 2004, The Journal of Immunology.

[45]  J. Mora,et al.  In vivo imaging of leukocyte trafficking in blood vessels and tissues. , 2004, Current opinion in immunology.

[46]  Michael Loran Dustin,et al.  LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. , 2004, Immunity.

[47]  Ulrich H. von Andrian,et al.  Homing and cellular traffic in lymph nodes , 2003, Nature Reviews Immunology.

[48]  M. Kosco-Vilbois Are follicular dendritic cells really good for nothing? , 2003, Nature Reviews Immunology.

[49]  M. Shlomchik,et al.  Reassessing the function of immune-complex retention by follicular dendritic cells , 2003, Nature Reviews Immunology.

[50]  M. Nolte,et al.  A Conduit System Distributes Chemokines and Small Blood-borne Molecules through the Splenic White Pulp , 2003, The Journal of experimental medicine.

[51]  A. Rudensky,et al.  Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. , 2003, Immunity.

[52]  Philippe Bousso,et al.  Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes , 2003, Nature Immunology.

[53]  Michael C. Carroll,et al.  B Lymphocyte Memory , 2002, The Journal of experimental medicine.

[54]  Tetsuo Yamazaki,et al.  T cell receptor ligation induces the formation of dynamically regulated signaling assemblies , 2002, The Journal of cell biology.

[55]  J. Kearney,et al.  Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. , 2002, Immunity.

[56]  R. Corley,et al.  Synergistic roles of IgM and complement in antigen trapping and follicular localization , 2002, European journal of immunology.

[57]  Philippe Bousso,et al.  Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy , 2002, Science.

[58]  R. Germain,et al.  Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes , 2002, Science.

[59]  Mark J. Miller,et al.  Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node , 2002, Science.

[60]  J. Kearney,et al.  Marginal-zone B cells , 2002, Nature Reviews Immunology.

[61]  C. Snapper,et al.  Dendritic Cells Pulsed with Intact Streptococcus pneumoniae Elicit both Protein- and Polysaccharide-specific Immunoglobulin Isotype Responses In Vivo through Distinct Mechanisms , 2002, The Journal of experimental medicine.

[62]  J. Tew,et al.  Follicular dendritic cells: beyond the necessity of T-cell help. , 2001, Trends in immunology.

[63]  M. Neuberger,et al.  B cells acquire antigen from target cells after synapse formation , 2001, Nature.

[64]  Stephen Shaw,et al.  Lymph-Borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex , 2000, The Journal of experimental medicine.

[65]  Shannon M. Anderson,et al.  Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells , 2000, The Journal of experimental medicine.

[66]  M. Davis,et al.  Differential clustering of CD4 and CD3zeta during T cell recognition. , 2000, Science.

[67]  J. Cyster,et al.  Follicular stromal cells and lymphocyte homing to follicles , 2000, Immunological reviews.

[68]  T. Manser,et al.  Fcγ Receptor IIB on Follicular Dendritic Cells Regulates the B Cell Recall Response1 , 2000, The Journal of Immunology.

[69]  K. Stiller,et al.  Microstructure of a boron containing high purity nickel-based alloy 690 , 2000 .

[70]  S. Gordon,et al.  A Member of the Dendritic Cell Family That Enters B Cell Follicles and Stimulates Primary Antibody Responses Identified by a Mannose Receptor Fusion Protein , 1999, The Journal of experimental medicine.

[71]  S. Bromley,et al.  The immunological synapse: a molecular machine controlling T cell activation. , 1999, Science.

[72]  Jianzhu Chen,et al.  A Critical Role of Natural Immunoglobulin M in Immediate Defense Against Systemic Bacterial Infection , 1998, The Journal of experimental medicine.

[73]  M. Carroll,et al.  Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses. , 1998, Journal of immunology.

[74]  Colin R. F. Monks,et al.  Three-dimensional segregation of supramolecular activation clusters in T cells , 1998, Nature.

[75]  M. Neuberger,et al.  Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[76]  A. Pombo,et al.  Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. , 1998, Journal of immunology.

[77]  E. Ingulli,et al.  Visualization of specific B and T lymphocyte interactions in the lymph node. , 1998, Science.

[78]  V. Holers,et al.  Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response. , 1998, Journal of immunology.

[79]  M. Neuberger,et al.  Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. , 1998, Immunity.

[80]  S. Korsmeyer,et al.  On the Key Role of Secondary Lymphoid Organs in Antiviral Immune Responses Studied in Alymphoplastic (aly/aly) and Spleenless (Hox11− /−) Mutant Mice , 1997, The Journal of experimental medicine.

[81]  Stephen Shaw,et al.  Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex , 1997, Immunological reviews.

[82]  S. Gordon,et al.  Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers , 1996, The Journal of experimental medicine.

[83]  K. Rajewsky Clonal selection and learning in the antibody system , 1996, Nature.

[84]  Christopher C. Goodnow,et al.  C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity , 1996, Science.

[85]  F. Sallusto,et al.  Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha , 1994, The Journal of experimental medicine.

[86]  T. K. van den Berg,et al.  Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcR gamma II-mediated immune-complex trapping. , 1993, Immunology.

[87]  I. Macdonald,et al.  Comparative aspects of splenic microcirculatory pathways in mammals: the region bordering the white pulp. , 1993, Scanning microscopy.

[88]  T. K. van den Berg,et al.  Selective inhibition of immune complex trapping by follicular dendritic cells with monoclonal antibodies against rat C3 , 1992, European journal of immunology.

[89]  E. Wisse,et al.  Lymphoid microenvironments in the thymus and lymph node. , 1988, Scanning microscopy.

[90]  H. Saito,et al.  Reticular meshwork of the spleen in rats studied by electron microscopy. , 1988, The American journal of anatomy.

[91]  L. Herzenberg,et al.  The LY‐1B Cell Lineage , 1986 .

[92]  G. Kraal,et al.  The differential effects of bacterial lipopolysaccharide (LPS) on splenic non-lymphoid cells demonstrated by monoclonal antibodies. , 1986, Immunology.

[93]  G. Kraal,et al.  In vivo effects of LPS on B lymphocyte subpopulations. Migration of marginal zone-lymphocytes and IgD-blast formation in the mouse spleen. , 1985, Immunobiology.

[94]  Antonio Lanzavecchia,et al.  Antigen-specific interaction between T and B cells , 1985, Nature.

[95]  K. Rock,et al.  Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors , 1984, The Journal of experimental medicine.

[96]  D. Gray,et al.  Relation of intra-splenic migration of marginal zone B cells to antigen localization on follicular dendritic cells. , 1984, Immunology.

[97]  K. Holmes,et al.  Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology. , 1983, Journal of immunology.

[98]  G. Klaus,et al.  The Follicular Dendritic Cell: Its Role in Antigen Presentation in the Generation of Immunological Memory , 1980, Immunological reviews.

[99]  A. Abbot,et al.  The Follicular Dendritic Cell: Long Term Antigen Retention During Immunity , 1980, Immunological reviews.

[100]  R. Phipps,et al.  The Maintenance and Regulation of the Humoral Immune Response: Persisting Antigen and the Role of Follicular Antigen‐Binding Dendritic Cells as Accessory Cells , 1980, Immunological reviews.

[101]  S. Fossum,et al.  The architecture of rat lymph nodes , 1980, Anatomy and Embryology.

[102]  K. Lennert,et al.  Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas. , 1980, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[103]  A. Farr,et al.  The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage. , 1980, The American journal of anatomy.

[104]  R. Steinman,et al.  Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells , 1978, The Journal of cell biology.

[105]  G. Klaus,et al.  The generation of memory cells. I. The role of C3 in the generation of B memory cells. , 1977, Immunology.

[106]  E. Holborow,et al.  Complement Dependence of Localisation of Aggregated IgG in Germinal Centres , 1975, Scandinavian journal of immunology.

[107]  E. Holborow,et al.  Lymphocyte-mediated Transport of Aggregated Human γ-Globulin into Germinal Centre Areas of Normal Mouse Spleen , 1970, Nature.

[108]  E. Unanue,et al.  Persistence of Antigen on the Surface of Macrophages , 1969, Nature.

[109]  G. Nossal,et al.  ANTIGENS IN IMMUNITY , 1968, The Journal of experimental medicine.

[110]  A. Abbot,et al.  Ultrastructure of the Antigen-retaining Reticulum of Lymph Node Follicles as shown by High-resolution Autoradiography , 1965, Nature.

[111]  G. Nossal,et al.  Antigens in immunity: VIII. Localization of 125I-labelled antigens in the secondary response , 1965 .

[112]  G. Nossal,et al.  ANTIGENS IN IMMUNITY , 1964, The Journal of experimental medicine.

[113]  S. L. Clark The reticulum of lymph nodes in mice studied with the electron microscope. , 1962, The American journal of anatomy.

[114]  Gowans Jl The effect of the continuous re-infusion of lymph and lymphocytes on the output of lymphocytes from the thoracic duct of unanaesthetized rats. , 1957 .

[115]  V. Tybulewicz,et al.  CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand , 2008, Nature Immunology.

[116]  M. Zachariah,et al.  Follicular shuttling of marginal zone B cells facilitates antigen transport , 2008, Nature Immunology.

[117]  J. Cyster,et al.  Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. , 2005, Annual review of immunology.

[118]  Michael Sixt,et al.  The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. , 2005, Immunity.

[119]  S Gordon,et al.  Macrophage receptors and immune recognition. , 2005, Annual review of immunology.

[120]  W. Hendrickson,et al.  DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. , 2002, Immunity.

[121]  B. Heyman,et al.  Regulation of antibody responses via antibodies, complement, and Fc receptors. , 2000, Annual review of immunology.

[122]  D. Chaplin,et al.  Development and maturation of secondary lymphoid tissues. , 1999, Annual review of immunology.

[123]  M. Carroll,et al.  The role of complement and complement receptors in induction and regulation of immunity. , 1998, Annual review of immunology.

[124]  G. Kraal Cells in the marginal zone of the spleen. , 1992, International review of cytology.

[125]  J. Tew,et al.  Microanatomy of lymphoid tissue during humoral immune responses: structure function relationships. , 1989, Annual review of immunology.

[126]  E. Brown,et al.  The role of the spleen in resistance to infection. , 1986, Annual review of medicine.

[127]  M. Moeremans,et al.  Transfer of immune complexes from lymphocytes to follicular dendritic cells , 1986, European journal of immunology.

[128]  I. Maclennan,et al.  Marginal zones: the major B cell compartment of rat spleens , 1981, European journal of immunology.

[129]  J. Humphrey,et al.  Different macrophage populations distinguished by means of fluorescent polysaccharides. Recognition and properties of marginal‐zone macrophages , 1981, European journal of immunology.

[130]  C. M. Austin,et al.  Antigens in Immunity , 1966 .