Highly selective and sensitive determination of dopamine by the novel molecularly imprinted poly(nicotinamide)/CuO nanoparticles modified electrode.

A novel electrochemical sensor was proposed for the determination of dopamine (DA) based on the molecularly imprinted electropolymers (MIPs)/copper oxide (CuO) nanoparticles modified electrode. MIPs were firstly prepared by using nicotinamide as an environment-friendly monomer to selectively recognize the template molecules. CuO nanoparticles were used to enhance the number of imprinted sites per unit surface area of the electrode and then improve the selectivity and sensitivity of the electrochemical sensor. Thus, the obtained electrochemical sensor could effectively minimize the interferences caused by ascorbic acid (AA), uric acid (UA) and sample matrix. The linear range for the detection of DA was changed from 0.02 μmol L(-1) to 25 μmol L(-1) with the detection limit of 8 nmol L(-1) (S/N=3), which was lower than those of the reported MIPs-based sensor. Finally, the proposed method was applied to measure dopamine in serum samples. The spiked recoveries were changed from 96.9% to 105.9% and the RSD was not higher than 8.8%. It was shown that the proposed sensor exhibited significant promise as a reliable technique for the detection of DA in human serum samples.

[1]  Mingyuan Du,et al.  Simultaneous quantification of seven hippocampal neurotransmitters in depression mice by LC–MS/MS , 2014, Journal of Neuroscience Methods.

[2]  Fuan Wang,et al.  Sensitive Biomimetic Sensor Based on Molecular Imprinting at Functionalized Indium Tin Oxide Electrodes , 2007 .

[3]  É. Grinenval,et al.  Spatially controlled immobilisation of biomolecules: A complete approach in green chemistry , 2014 .

[4]  Tingting Wen,et al.  Novel electrochemical sensing platform based on magnetic field-induced self-assembly of Fe3O4@Polyaniline nanoparticles for clinical detection of creatinine. , 2014, Biosensors & bioelectronics.

[5]  Jianping Li,et al.  A strategy for improving the sensitivity of molecularly imprinted electrochemical sensors based on catalytic copper deposition. , 2014, Analytica chimica acta.

[6]  L. Lee,et al.  A dopamine electrochemical sensor based on molecularly imprinted poly(acrylamidophenylboronic acid) film , 2013 .

[7]  Ling-Jie Kong,et al.  Molecularly imprinted quartz crystal microbalance sensor based on poly(o-aminothiophenol) membrane and Au nanoparticles for ractopamine determination. , 2014, Biosensors & bioelectronics.

[8]  Li Niu,et al.  Electrochemical sensor for dopamine based on a novel graphene-molecular imprinted polymers composite recognition element. , 2011, Biosensors & bioelectronics.

[9]  Ling-bo Qu,et al.  Nano-sized copper oxide/multi-wall carbon nanotube/Nafion modified electrode for sensitive detection of dopamine , 2013 .

[10]  Behzad Rezaei,et al.  A novel electrochemical nanocomposite imprinted sensor for the determination of lorazepam based on modified polypyrrole@sol-gel@gold nanoparticles/pencil graphite electrode , 2014 .

[11]  Nianjun Yang,et al.  Cyclic voltammetric response of nicotinic acid and nicotinamide on a polycrystalline gold electrode , 2006 .

[12]  Yang Wang,et al.  Amperometric detection of dopamine in human serum by electrochemical sensor based on gold nanoparticles doped molecularly imprinted polymers. , 2013, Biosensors & bioelectronics.

[13]  Robert C. Davis,et al.  Chemical vapor deposition of three aminosilanes on silicon dioxide: surface characterization, stability, effects of silane concentration, and cyanine dye adsorption. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[14]  A. Srivastava,et al.  Polarographic behavior of nicotinamide in surfactant media and its determination in cetyltrimethylammonium bromide surfactant system. , 2008, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[15]  Ying Zhang,et al.  Efficient synthesis of narrowly dispersed hydrophilic and magnetic molecularly imprinted polymer microspheres with excellent molecular recognition ability in a real biological sample. , 2014, Chemical communications.

[16]  I. Bulut,et al.  Electrochemical study of the interaction of nicotinamide with tryptophan in the presence and absence of nickel(II) , 2001 .

[17]  Sathish Reddy,et al.  CuO nanoparticle sensor for the electrochemical determination of dopamine , 2012 .

[18]  Xiaohong Zhu,et al.  Eletropolymerization of Niacinamide for Fabrication of Electrochemical Sensor: Simultaneous Determination of Dopamine, Uric Acid and Ascorbic Acid , 2009 .

[19]  W. Kutner,et al.  Electrochemically synthesized polymers in molecular imprinting for chemical sensing , 2012, Analytical and Bioanalytical Chemistry.

[20]  B. D. Malhotra,et al.  Molecularly imprinted polyaniline-polyvinyl sulphonic acid composite based sensor for para-nitrophenol detection. , 2013, Analytica chimica acta.

[21]  Sergey A. Piletsky,et al.  Electrochemical sensor for catechol and dopamine based on a catalytic molecularly imprinted polymer-conducting polymer hybrid recognition element. , 2009, Analytical chemistry.

[22]  Jianping Li,et al.  A sensitive and selective sensor for dopamine determination based on a molecularly imprinted electropolymer of o-aminophenol , 2009 .

[23]  Dan Wu,et al.  Sensitive and selective determination of dopamine by electrochemical sensor based on molecularly imprinted electropolymerization of o-phenylenediamine , 2013 .

[24]  R. Saboori,et al.  Synthesis and characterization of mono sized CuO nanoparticles , 2012 .

[25]  Chen Li,et al.  Imprinted electrochemical sensor for dopamine recognition and determination based on a carbon nanotube/polypyrrole film , 2012 .

[26]  Daming Gao,et al.  Molecular imprinting at walls of silica nanotubes for TNT recognition. , 2008, Analytical chemistry.

[27]  Xiaoping Zhou,et al.  Ultrasensitive dopamine sensor based on novel molecularly imprinted polypyrrole coated carbon nanotubes. , 2014, Biosensors & bioelectronics.

[28]  Xianwen Kan,et al.  Composites of Multiwalled Carbon Nanotubes and Molecularly Imprinted Polymers for Dopamine Recognition , 2008 .