Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore.
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S. Sakya | Kevin Ogilvie | Jason K. Dutra | Chewah Lee | R. Lira | B. O’Neill | M. Brodney | Christopher J. Helal | Joseph Young | Erik A Lachapelle | J. Murray | Erik A. Lachapelle