MENTAL DEFICIENCY

respiration, but also after this centre -has been damaged or depressed, as by morphine. Mere tracings of the respiration before and after administration of any drug do not reveal the whole truth. Tests can be made on human patients in a way closely similar to laboratory experiments. Moncrieff and his colleagues did this when treating patients suffering from the effects of morphine and other sedative drugs, taken with suicidal intent. Oxygen was administered from a recording spirometer apparatus, with a mask strapped over the face. The breathing was recorded on a revolving drum and the effects of certain drugs were noted. Except in the moribund, definite stimulation of breathing was always obtained by allowing carbon dioxide to accumulate, and also by lobeline and other drugs. The most striking feature of the tests was the complete absence of any regular stimulant effect on respiration by strychnine, caffeine, atropine, pituitrin or adrenaline. Occasionally a phase of irregular breathing followed adrenaline.

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