Editorial: Recent Advances in Pathophysiological Studies and Treatment of Epilepsy

Secondly, substance P is widely distributed in the regions of the central nervous system associated with epilepsy and it contributes to the initiation and maintenance phases of epilepsy. In vivo, substance P binds to the neurokinin-1 receptor and modulates the biological activity of the receptor. Although NK-1 receptor antagonists have anti-epileptic properties in animal models [4, 5], the clinical efficacy of these drugs has not yet been verified. Therefore, Dr. Chi provides an overview of current understanding of the structural and functional mechanisms of the substance P involved in regulating epilepsy pathologic process [6].

[1]  Edward F. Chang,et al.  Seizure outcomes in nonresective epilepsy surgery: an update , 2017, Neurosurgical Review.

[2]  Hong-Ki Song,et al.  Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment , 2017, Brain Research.

[3]  F. Tang,et al.  Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis , 2016, Current neuropharmacology.

[4]  Michael R Sperling,et al.  Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy , 2016, Epilepsia.

[5]  B. Blass.  Sulfonamide Derivatives and Pharmaceutical Applications Thereof. , 2016, ACS medicinal chemistry letters.

[6]  Dong Zhou,et al.  Review of the use of botanicals for epilepsy in complementary medical systems — Traditional Chinese Medicine , 2015, Epilepsy & Behavior.

[7]  Lei Xiang,et al.  MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons , 2015, Brain Research.

[8]  M. Duchowny,et al.  MR‐guided laser interstitial thermal therapy for pediatric drug‐resistant lesional epilepsy , 2015, Epilepsia.

[9]  R. Voskuyl,et al.  MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells , 2015, Scientific Reports.

[10]  Yuan Wu,et al.  Grouping Pentylenetetrazol-Induced Epileptic Rats According to Memory Impairment and MicroRNA Expression Profiles in the Hippocampus , 2015, PloS one.

[11]  Hong-Ki Song,et al.  Cytidine 5′-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death , 2015, Brain Research.

[12]  Jing Zhao,et al.  The Anticonvulsant Effects of SR 57227 on Pentylenetetrazole-Induced Seizure in Mice , 2014, PloS one.

[13]  Yingjie Guo,et al.  Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy , 2013, Epilepsy Research.

[14]  G. Capovilla,et al.  Epilepsy and vaccinations: Italian guidelines , 2013, Epilepsia.

[15]  M. Ghasemi,et al.  Seizure susceptibility alteration through 5-HT3 receptor: Modulation by nitric oxide , 2010, Seizure.

[16]  Y. Urade,et al.  Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. , 2004, Archives italiennes de biologie.

[17]  S. Baraban,et al.  Interneuron Diversity series: Interneuronal neuropeptides – endogenous regulators of neuronal excitability , 2004, Trends in Neurosciences.

[18]  M. Cortez,et al.  Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet , 2003, Annals of neurology.

[19]  Anne Williamson,et al.  A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories , 2003, Epilepsia.

[20]  K. Kelly,et al.  Quantitative reverse transcription-polymerase chain reaction of GABAA α1, β1 and γ2S subunits in epileptic rats following photothrombotic infarction of neocortex , 2002, Epilepsy Research.

[21]  J. Rho,et al.  Acetoacetate, Acetone, and Dibenzylamine (a Contaminant in l‐(+)‐β‐Hydroxybutyrate) Exhibit Direct Anticonvulsant Actions in Vivo , 2002, Epilepsia.

[22]  K. Kelly,et al.  Quantitative reverse transcription-polymerase chain reaction of GABA(A) alpha1, beta1 and gamma2S subunits in epileptic rats following photothrombotic infarction of neocortex. , 2002, Epilepsy research.