Genes that mediate breast cancer metastasis to lung

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

[1]  S. Devesa,et al.  Probabilities of death from breast cancer and other causes among female breast cancer patients. , 2004, Journal of the National Cancer Institute.

[2]  René Bernards,et al.  A progression puzzle. , 2002, Nature.

[3]  Christian A. Rees,et al.  Molecular portraits of human breast tumours , 2000, Nature.

[4]  M. Olivé,et al.  Long-term human breast carcinoma cell lines of metastatic origin: Preliminary characterization , 1978, In Vitro.

[5]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[6]  R. Hynes.  Metastatic Potential Generic Predisposition of the Primary Tumor or Rare, Metastatic Variants—Or Both? , 2003, Cell.

[7]  P. Goss,et al.  The role of COX-2 inhibition in breast cancer treatment and prevention. , 2004, Seminars in oncology.

[8]  S. Hellman,et al.  Clinical progression of breast cancer malignant behavior: what to expect and when to expect it. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  I. Macdonald,et al.  Metastasis: Dissemination and growth of cancer cells in metastatic sites , 2002, Nature Reviews Cancer.

[10]  Y. Yarden,et al.  Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.

[11]  Van,et al.  A gene-expression signature as a predictor of survival in breast cancer. , 2002, The New England journal of medicine.

[12]  C. Cordon-Cardo,et al.  A multigenic program mediating breast cancer metastasis to bone. , 2003, Cancer cell.

[13]  I. Fidler,et al.  The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited , 2003, Nature Reviews Cancer.

[14]  R. Blasberg,et al.  A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging , 2004, European Journal of Nuclear Medicine and Molecular Imaging.

[15]  M. Duffy,et al.  Metalloproteinases: role in breast carcinogenesis, invasion and metastasis , 2000, Breast Cancer Research.

[16]  E. Lander,et al.  A molecular signature of metastasis in primary solid tumors , 2003, Nature Genetics.

[17]  F. Balkwill.  Cancer and the chemokine network , 2004, Nature Reviews Cancer.

[18]  Michael J. Grusby,et al.  Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2 , 2003, The Journal of experimental medicine.

[19]  Eric S. Lander,et al.  Genomic analysis of metastasis reveals an essential role for RhoC , 2000, Nature.

[20]  R Simon,et al.  Diagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data , 2003, British Journal of Cancer.

[21]  R Kath,et al.  Tumor progression and metastasis , 1990, Zentralblatt fur Chirurgie.

[22]  A. Berner,et al.  Altered Expression of Metastasis-Associated and Regulatory Molecules in Effusions from Breast Cancer Patients , 2004, Clinical Cancer Research.

[23]  Jean-Philippe Coppé,et al.  Helix-Loop-Helix Proteins in Mammary Gland Development and Breast Cancer , 2003, Journal of Mammary Gland Biology and Neoplasia.

[24]  G. Bastert,et al.  Metastatic breast cancer: clinical course, prognosis and therapy related to the first site of metastasis , 2000, Breast Cancer Research and Treatment.

[25]  Z. Werb,et al.  New functions for the matrix metalloproteinases in cancer progression , 2002, Nature Reviews Cancer.

[26]  C. Malone,et al.  Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma. , 2002, European journal of cancer.

[27]  S. Ramaswamy,et al.  Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis , 2004, Cell.

[28]  H. Auer,et al.  Tissue-Wide Expression Profiling Using cDNA Subtraction and Microarrays to Identify Tumor-Specific Genes , 2004, Cancer Research.

[29]  Y. Yarden,et al.  Epiregulin Is a Potent Pan-ErbB Ligand That Preferentially Activates Heterodimeric Receptor Complexes* , 1998, The Journal of Biological Chemistry.

[30]  R. Benezra,et al.  Id proteins in development, cell cycle and cancer. , 2003, Trends in cell biology.

[31]  E. Sage,et al.  SPARC and tumor growth: Where the seed meets the soil? , 2004, Journal of cellular biochemistry.

[32]  David E. Misek,et al.  Gene-expression profiles predict survival of patients with lung adenocarcinoma , 2002, Nature Medicine.

[33]  W. Gerald,et al.  Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. , 2005, The Journal of clinical investigation.