Pilot Clinical Trial of Type 1 Dendritic Cells Loaded with Autologous Tumor Lysates Combined with GM-CSF, Pegylated IFN, and Cyclophosphamide for Metastatic Cancer Patients
暂无分享,去创建一个
B. Sangro | I. Melero | S. Martín-Algarra | J. Pérez-Gracia | Álvaro González | S. Hervás-Stubbs | M. Redrado | A. Calvo | J. Richter | I. Martinez-Forero | I. Peñuelas | J. Richter | A. Benito | C. Vigil | E. Bolaños | I. Rodríguez | C. Alfaro | N. Suárez | Javier Rodríguez | A. Agliano | J. Pérez-Calvo | J. Rodriguez | M. Fernandez de Sanmamed | A. Gonzalez | I. Rodriguez | S. Martín-Algarra | J. Perez-Gracia | Jose L. Perez-Gracia | Miguel Fernandez de Sanmamed | Miriam Redrado | Alice Agliano | Elixabet Bolaños | Sandra Hervás-Stubbs | Javier Perez-Calvo | Ivan Martinez-Forero | Ignacio Melero | M. Fernández de Sanmamed | S. Martı́n-Algarra | Natalia Suárez
[1] K. Kakimi,et al. [Dendritic cells for cancer immunotherapy]. , 2012, Nihon rinsho. Japanese journal of clinical medicine.
[2] J. Kirkwood,et al. Helper Activity of Natural Killer Cells During the Dendritic Cell-mediated Induction of Melanoma-specific Cytotoxic T Cells , 2011, Journal of immunotherapy.
[3] S. Aamdal,et al. hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes , 2011, Cancer Immunology, Immunotherapy.
[4] H. Ueno,et al. Recent Developments in Cancer Vaccines , 2011, The Journal of Immunology.
[5] J. Banchereau,et al. Type‐1 polarized dendritic cells loaded with apoptotic prostate cancer cells are potent inducers of CD8+ T cells against prostate cancer cells and defined prostate cancer‐specific epitopes , 2011, The Prostate.
[6] J. Engh,et al. Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in patients with recurrent malignant glioma. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[7] M. Caligiuri,et al. Innate or Adaptive Immunity? The Example of Natural Killer Cells , 2011, Science.
[8] C. Punt,et al. Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents , 2010, Clinical Cancer Research.
[9] T. Taniguchi,et al. Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation , 2010, The Journal of experimental medicine.
[10] R. Steinman. Some active areas of DC research and their medical potential , 2010, European journal of immunology.
[11] Israel Lowy,et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] Anna M. Keller,et al. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells , 2010, The Journal of experimental medicine.
[13] H. Okada,et al. Polarized dendritic cells as cancer vaccines: directing effector-type T cells to tumors. , 2010, Seminars in immunology.
[14] F. Bertolini,et al. Circulating endothelial cells as biomarkers in clinical oncology. , 2010, Microvascular research.
[15] Zhuoshun Yang,et al. Selective depletion of CD4+CD25+Foxp3+ regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels. , 2010, Cancer research.
[16] W. Heath,et al. The CD8+ dendritic cell subset , 2010, Immunological reviews.
[17] John M.L. Ebos,et al. Phase I/II trial of metronomic chemotherapy with daily dalteparin and cyclophosphamide, twice-weekly methotrexate, and daily prednisone as therapy for metastatic breast cancer using vascular endothelial growth factor and soluble vascular endothelial growth factor receptor levels as markers of respon , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[18] T. Ley,et al. Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. , 2009, Cancer research.
[19] B. Sangro,et al. Clinical development of combination strategies in immunotherapy: are we ready for more than one investigational product in an early clinical trial? , 2009, Immunotherapy.
[20] A. Schned,et al. Clinical and Immunologic Effects of Intranodal Autologous Tumor Lysate-Dendritic Cell Vaccine with Aldesleukin (Interleukin 2) and IFN-α2a Therapy in Metastatic Renal Cell Carcinoma Patients , 2009, Clinical Cancer Research.
[21] W. Oyen,et al. Limited Amounts of Dendritic Cells Migrate into the T-Cell Area of Lymph Nodes but Have High Immune Activating Potential in Melanoma Patients , 2009, Clinical Cancer Research.
[22] I. Melero,et al. Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes , 2009, British Journal of Cancer.
[23] D. Kerr,et al. A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma , 2009, Hepatology.
[24] I. Tirapu,et al. Freeze‐and‐thaw‐disrupted tumour cells impair the responsiveness of DC to TLR stimulation , 2008, European journal of immunology.
[25] C. Melief. Cancer immunotherapy by dendritic cells. , 2008, Immunity.
[26] A. Melcher,et al. Optimization of Dendritic Cell Loading With Tumor Cell Lysates for Cancer Immunotherapy , 2008, Journal of immunotherapy.
[27] C. Figdor,et al. Dendritic cell vaccination and immune monitoring , 2008, Cancer Immunology, Immunotherapy.
[28] D. Pennington,et al. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. , 2008, The Journal of clinical investigation.
[29] B. Neyns,et al. Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.
[30] F. Belardelli,et al. Dendritic cells and cytokines in immune rejection of cancer. , 2008, Cytokine & growth factor reviews.
[31] L. Bracci,et al. IFN‐α and Novel Strategies of Combination Therapy for Cancer , 2007 .
[32] John E. Connolly,et al. IL‐15‐induced human DC efficiently prime melanoma‐specific naive CD8+ T cells to differentiate into CTL , 2007, European journal of immunology.
[33] I. Melero,et al. Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer , 2007, Expert opinion on biological therapy.
[34] E. Gilboa. DC-based cancer vaccines. , 2007, The Journal of clinical investigation.
[35] B. Chauffert,et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients , 2007, Cancer Immunology, Immunotherapy.
[36] G. Rabinovich,et al. Immunosuppressive strategies that are mediated by tumor cells. , 2007, Annual review of immunology.
[37] H. Ueno,et al. Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34+ progenitor-derived dendritic cells , 2006, Cancer Immunology, Immunotherapy.
[38] G. Dranoff. The Therapeutic Implications of Intratumoral Regulatory T Cells , 2005, Clinical Cancer Research.
[39] L. Zitvogel,et al. Natural killer cell–dendritic cell crosstalk in the initiation of immune responses , 2005, Expert opinion on biological therapy.
[40] J. Prieto,et al. Dendritic cells delivered inside human carcinomas are sequestered by interleukin‐8 , 2005, International journal of cancer.
[41] J. Prieto,et al. Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[42] L. Zitvogel,et al. NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. , 2004, Blood.
[43] M. Atkins,et al. Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses , 2004, Clinical Cancer Research.
[44] T. Olencki,et al. Clinical and immunologic effects of subcutaneously administered interleukin-12 and interferon alfa-2b: phase I trial of patients with metastatic renal cell carcinoma or malignant melanoma. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[45] R. Kalluri,et al. Thrombospondin-1 Associated with Tumor Microenvironment Contributes to Low-Dose Cyclophosphamide-Mediated Endothelial Cell Apoptosis and Tumor Growth Suppression , 2004, Cancer Research.
[46] R. Foà,et al. IFN-alpha promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment. , 2004, Blood.
[47] P. Morel,et al. Dendritic Cells Mediate NK Cell Help for Th1 and CTL Responses: Two-Signal Requirement for the Induction of NK Cell Helper Function 1 , 2003, The Journal of Immunology.
[48] T. Curiel,et al. Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity , 2003, Nature Medicine.
[49] Donna Niedzwiecki,et al. Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. , 2003, Cancer research.
[50] G. Trinchieri,et al. Interleukin-12 and the regulation of innate resistance and adaptive immunity , 2003, Nature Reviews Immunology.
[51] J. Prieto,et al. αvβ3 Integrin-Mediated Adenoviral Transfer of Interleukin-12 at the Periphery of Hepatic Colon Cancer Metastases Induces VCAM-1 Expression and T-Cell Recruitment , 2001 .
[52] J. Prieto,et al. Alpha(v)beta(3) integrin-mediated adenoviral transfer of interleukin-12 at the periphery of hepatic colon cancer metastases induces VCAM-1 expression and T-cell recruitment. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.
[53] Lieping Chen,et al. IL-12 gene therapy for cancer: in synergy with other immunotherapies. , 2001, Trends in immunology.
[54] Eli Gilboa,et al. Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. , 2000, Nature Medicine.
[55] A. Enk,et al. Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma , 1999, The Journal of experimental medicine.
[56] J. Prieto,et al. Different doses of adenoviral vector expressing IL-12 enhance or depress the immune response to a coadministered antigen: the role of nitric oxide. , 1999, Journal of immunology.
[57] Dirk Schadendorf,et al. Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells , 1998, Nature Medicine.
[58] H. Rammensee,et al. Priming of cytotoxic T lymphocytes by five heat‐aggregated antigens in vivo: Conditions, efficiency, and relation to antibody responses , 1997, European journal of immunology.
[59] L. Zitvogel,et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity , 1995, Nature Medicine.
[60] C. Punt,et al. Cancer Therapy : Clinical Frequency of Circulating Tregs with Demethylated FOXP 3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents , 2011 .
[61] C. Melief,et al. Cancer immunology. , 2011, Current opinion in immunology.
[62] L. Bracci,et al. IFN-alpha and novel strategies of combination therapy for cancer. , 2007, Annals of the New York Academy of Sciences.
[63] M. Serio,et al. Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity. , 2001, The Journal of clinical investigation.
[64] J. Teruya-Feldstein,et al. Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12. , 1999, Blood.
[65] Edgar G. Engleman,et al. Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells , 1996, Nature Medicine.