The crystal structure of diphtheria toxin

[1]  D. Eisenberg,et al.  Assessment of protein models with three-dimensional profiles , 1992, Nature.

[2]  A. Brunger Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. , 1992 .

[3]  D. Eisenberg,et al.  Crystallization of diphtheria toxin. , 1991, Journal of molecular biology.

[4]  D. Ellar,et al.  Crystal structure of insecticidal δ-endotoxin from Bacillus thuringiensis at 2.5 Å resolution , 1991, Nature.

[5]  T. Sixma,et al.  Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli , 1991, Nature.

[6]  Axel T. Brunger,et al.  Solution of a Fab (26-10)/digoxin complex by generalized molecular replacement , 1991 .

[7]  Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells. , 1991, Protein engineering.

[8]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[9]  H. Stenmark,et al.  Insertion of diphtheria toxin B-fragment into the plasma membrane at low pH. Characterization and topology of inserted regions. , 1991, The Journal of biological chemistry.

[10]  G. Schiavo,et al.  Tyrosine 65 is photolabeled by 8-azidoadenine and 8-azidoadenosine at the NAD binding site of diphtheria toxin. , 1991, The Journal of biological chemistry.

[11]  I. Pastan,et al.  A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[12]  A T Brünger,et al.  Slow-cooling protocols for crystallographic refinement by simulated annealing. , 1990, Acta crystallographica. Section A, Foundations of crystallography.

[13]  P. Main,et al.  The use of Sayre's equation with solvent flattening and histogram matching for phase extension and refinement of protein structures , 1990 .

[14]  S. Sprang,et al.  The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding. , 1990, The Journal of biological chemistry.

[15]  K. Sletten,et al.  Translocation of diphtheria toxin A-fragment to the cytosol. Role of the site of interfragment cleavage. , 1989, The Journal of biological chemistry.

[16]  D Eisenberg,et al.  Hydrophobic organization of membrane proteins. , 1989, Science.

[17]  G. Schiavo,et al.  Histidine 21 is at the NAD+ binding site of diphtheria toxin. , 1989, The Journal of biological chemistry.

[18]  D. I. Stuart,et al.  Structure of tumour necrosis factor , 1989, Nature.

[19]  D. Tsernoglou,et al.  Structure of the membrane-pore-forming fragment of colicin A , 1989, Nature.

[20]  R. Rappuoli,et al.  Selective immunotoxins prepared with mutant diphtheria toxins coupled to monoclonal antibodies. , 1989, Methods in enzymology.

[21]  E. London,et al.  Localization of the active site of diphtheria toxin. , 1988, Biochemistry.

[22]  S. Carroll,et al.  Amino acid sequence homology between the enzymic domains of diphtheria toxin and Pseudomonas aeruginosa exotoxin A , 1988, Molecular microbiology.

[23]  D. Mckay,et al.  Mapping the enzymatic active site of Pseudomonas aeruginosa exotoxin A , 1988, Proteins.

[24]  G. Schiavo,et al.  Lipid interaction of diphtheria toxin and mutants with altered fragment B. 2. Hydrophobic photolabelling and cell intoxication. , 1987, European journal of biochemistry.

[25]  R. Youle,et al.  Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity. , 1987, Science.

[26]  J. Ponder,et al.  Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes. , 1987, Journal of molecular biology.

[27]  W. Bishai,et al.  Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein. , 1987, Protein engineering.

[28]  David Eisenberg,et al.  Generalized method of determining heavy-atom positions using the difference Patterson function , 1987 .

[29]  R. Collier,et al.  Dimeric form of diphtheria toxin: purification and characterization. , 1986, Biochemistry.

[30]  D. Mckay,et al.  Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[31]  E. London,et al.  Effect of pH on the conformation of diphtheria toxin and its implications for membrane penetration. , 1985, Biochemistry.

[32]  R. Collier,et al.  Circular dichroism of diphtheria toxin, Pseudomonas aeruginosa exotoxin A, and various derivatives. , 1985, Biochimica et biophysica acta.

[33]  Jones Ta,et al.  Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO. , 1985, Methods in enzymology.

[34]  B. C. Wang Resolution of phase ambiguity in macromolecular crystallography. , 1985, Methods in enzymology.

[35]  R. Collier,et al.  NAD binding site of diphtheria toxin: identification of a residue within the nicotinamide subsite by photochemical modification with NAD. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[36]  R. Rappuoli,et al.  The amino-acid sequence of two non-toxic mutants of diphtheria toxin: CRM45 and CRM197. , 1984, Nucleic acids research.

[37]  G. Buck,et al.  Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. Eisenberg,et al.  X-ray grade crystals of diphtheria toxin. , 1982, The Journal of biological chemistry.

[39]  K. Sandvig,et al.  Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule. , 1981, The Journal of biological chemistry.

[40]  A. Finkelstein,et al.  Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[41]  M. Simon,et al.  Diphtheria toxin forms transmembrane channels in planar lipid bilayers. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[42]  J. Richardson,et al.  The anatomy and taxonomy of protein structure. , 1981, Advances in protein chemistry.

[43]  R. Proia,et al.  Characterization and affinity labeling of the cationic phosphate-binding (nucleotide-binding) peptide located in the receptor-binding region of the B-fragment of diphtheria toxin. , 1980, The Journal of biological chemistry.

[44]  J Deisenhofer,et al.  Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 A and 1.0 A resolution. , 1980, Journal of molecular biology.

[45]  S. Lory,et al.  Diphtheria toxin: nucleotide binding and toxin heterogeneity. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[46]  E. Mekada,et al.  One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell , 1978, Cell.

[47]  S. McLaughlin Electrostatic Potentials at Membrane-Solution Interfaces , 1977 .

[48]  R. Collier,et al.  Structure and activity of diphtheria toxin. I. Thiol-dependent dissociation of a fraction of toxin into enzymically active and inactive fragments. , 1971, The Journal of biological chemistry.

[49]  D. Blow,et al.  The detection of sub‐units within the crystallographic asymmetric unit , 1962 .