Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
暂无分享,去创建一个
Dave T. Gerrard | Hassan Malik | Ludovic Vallier | Neil A. Hanley | N. Hanley | L. Vallier | N. Kitteringham | C. Goldring | C. Rowe | H. Malik | R. Sison-Young | S. Fenwick | Sarah Withey | M. Baxter | Stephen W. Fenwick | Charis-Patricia Segeritz | Sarah Withey | Fang Zhang | R. Jenkins | Cliff Rowe | Sean Harrison | Melissa Baxter | Charis-Patricia Segeritz | Fang Zhang | Rebecca Atkinson-Dell | Rowena Sison-Young | Roz Jenkins | Joanne Henry | Andrew A. Berry | Lisa Mohamet | Marie Best | Neil R. Kitteringham | Chris E. Goldring | Karen Piper Hanley | L. Mohamet | R. Atkinson-Dell | S. Harrison | K. Piper Hanley | Marie B. Best | J. Henry
[1] E. Kroon,et al. Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells , 2006, Nature Biotechnology.
[2] Ludovic Vallier,et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. , 2010, The Journal of clinical investigation.
[3] Robert Lanza,et al. Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells , 2008, Stem cells.
[4] Genevieve Konopka,et al. HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells , 2011, Development.
[5] F. Nevens,et al. Human Embryonic and Rat Adult Stem Cells with Primitive Endoderm-Like Phenotype Can Be Fated to Definitive Endoderm, and Finally Hepatocyte-Like Cells , 2010, PloS one.
[6] R. McKay,et al. Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. , 2012, Gastroenterology.
[7] C. C. West,et al. Robust generation of hepatocyte-like cells from human embryonic stem cell populations. , 2011, Journal of visualized experiments : JoVE.
[8] Jehyuk Lee,et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells , 2009, Hepatology.
[9] J. Adamson,et al. Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis , 2003, Nature Genetics.
[10] M. Omary,et al. Toward unraveling the complexity of simple epithelial keratins in human disease. , 2009, The Journal of clinical investigation.
[11] Hayley S. Brown,et al. Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies , 2007, Drug metabolism reviews.
[12] T. Kono,et al. Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study , 2012, Histopathology.
[13] M. Nyirenda,et al. Prenatal programming of hepatocyte nuclear factor 4α in the rat: a key mechanism in the ‘foetal origins of hyperglycaemia’? , 2006, Diabetologia.
[14] Dave T. Gerrard,et al. Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation , 2013, Hepatology.
[15] H. Deng,et al. Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects , 2012, Cell Research.
[16] Catherine Payne,et al. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling , 2008, Proceedings of the National Academy of Sciences.
[17] S. Kimber,et al. Analysis of the distinct functions of growth factors and tissue culture substrates necessary for the long-term self-renewal of human embryonic stem cell lines. , 2009, Stem cell research.
[18] Xiaolei Yin,et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells , 2009, Cell Research.
[19] Hung-Chih Kuo,et al. Rapid generation of mature hepatocyte‐like cells from human induced pluripotent stem cells by an efficient three‐step protocol , 2012, Hepatology.
[20] A. Schambach,et al. Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. , 2011, Human molecular genetics.
[21] R. Pedersen,et al. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development , 2010, Hepatology.
[22] Ludovic Vallier,et al. Production of hepatocyte-like cells from human pluripotent stem cells , 2013, Nature Protocols.
[23] B. Shields,et al. The Diabetic Phenotype in HNF4A Mutation Carriers Is Moderated By the Expression of HNF4A Isoforms From the P1 Promoter During Fetal Development , 2008, Diabetes.
[24] S. Duncan,et al. Protocol for directed differentiation of human pluripotent stem cells toward a hepatocyte fate , 2014 .
[25] R. Bataller,et al. Liver progenitor cell markers correlate with liver damage and predict short‐term mortality in patients with alcoholic hepatitis , 2012, Hepatology.
[26] Magnus Ingelman-Sundberg,et al. Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage. , 2010, Journal of biotechnology.
[27] Anne E Carpenter,et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation , 2013, Nature chemical biology.
[28] T. Hearn,et al. Development of the Human Pancreas From Foregut to Endocrine Commitment , 2013, Diabetes.
[29] David C Hay,et al. Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo , 2008, Stem cells.
[30] L. Chavez,et al. Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation. , 2011, Stem cells and development.
[31] Zheng Li,et al. Generation, characterization and potential therapeutic applications of mature and functional hepatocytes from stem cells , 2013, Journal of cellular physiology.
[32] H. Aburatani,et al. Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. , 2005, Genomics.
[33] J. Ruijter,et al. Hepatic HNF4α deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes , 2007, Hepatology.
[34] F. Sladek,et al. HNF4α--role in drug metabolism and potential drug target? , 2010, Current opinion in pharmacology.
[35] Cole Trapnell,et al. How to map billions of short reads onto genomes , 2009, Nature Biotechnology.
[36] Mark Bradley,et al. Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism. , 2011, Stem cell research.
[37] N. Hanley,et al. Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. , 2010, Stem cell research.
[38] Tom H. Pringle,et al. The human genome browser at UCSC. , 2002, Genome research.
[39] Stephen Dalton,et al. Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells , 2010, Hepatology.
[40] Alejandro Soto-Gutiérrez,et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. , 2009, Gastroenterology.