Pilot study: Raman spectroscopy in differentiating premalignant and malignant oral lesions from normal mucosa and benign lesions in humans

Current practice for differentiating tissue lesions are based on histopathological criteria. This process is subject to error. The purpose of this study was to test whether an alternative, tissue‐based molecular signatures Raman spectra could be used to differentiate premalignant and malignant lesions from normal mucosa or benign lesions.

[1]  D. McLean,et al.  Real-time Raman Spectroscopy for in Vivo Skin Cancer Diagnosis Raman Spectroscopy of Skin Cancer , 2022 .

[2]  Vijayashree S. Bhattar,et al.  Accuracy of In Vivo Multimodal Optical Imaging for Detection of Oral Neoplasia , 2012, Cancer Prevention Research.

[3]  Alexandros D. Polydorides,et al.  Discrimination of Benign and Neoplastic Mucosa with a High-Resolution Microendoscope (HRME) in Head and Neck Cancer , 2012, Annals of Surgical Oncology.

[4]  Timothy J Muldoon,et al.  Noninvasive imaging of oral neoplasia with a high-resolution fiber-optic microendoscope , 2012, Head & neck.

[5]  Haishan Zeng,et al.  Using Laser Raman Spectroscopy to Reduce False Positives of Autofluorescence Bronchoscopies: A Pilot Study , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[6]  H. Zeng,et al.  Comparison of molecular images as defined by Raman spectra between normal mucosa and squamous cell carcinoma in the oral cavity , 2011 .

[7]  H. Tashiro,et al.  Improvement and analysis of a micro Raman probe. , 2009, Applied optics.

[8]  H. Zeng,et al.  Parameters defining the potential applicability of Raman spectroscopy as a diagnostic tool for oral disease. , 2009, Journal of biomedical optics.

[9]  S. Lam,et al.  Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers. , 2008, Optics letters.

[10]  H. Saleh,et al.  Fine needle aspiration biopsy of intraoral and oropharyngeal mass lesions , 2008, CytoJournal.

[11]  B. Wong,et al.  Imaging of the Pediatric Airway Using Optical Coherence Tomography , 2007, The Laryngoscope.

[12]  Y. Seta,et al.  Immunohistochemical identification of cells expressing steroidogenic enzymes cytochrome P450scc and P450 aromatase in taste buds of rat circumvallate papillae. , 2007, Archives of histology and cytology.

[13]  D. McLean,et al.  Automated Autofluorescence Background Subtraction Algorithm for Biomedical Raman Spectroscopy , 2007, Applied Spectroscopy.

[14]  A. Talari,et al.  Raman Spectroscopy of Biological Tissues , 2007 .

[15]  Haishan Zeng,et al.  Changes in nuclei and peritumoral collagen within nodular basal cell carcinomas via confocal micro-Raman spectroscopy. , 2006, Journal of biomedical optics.

[16]  Christoph Krafft,et al.  Near infrared Raman spectra of human brain lipids. , 2005, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[17]  H. Barr,et al.  Raman spectroscopy for identification of epithelial cancers. , 2004, Faraday discussions.

[18]  Haishan Zeng,et al.  Raman spectroscopy of in vivo cutaneous melanin. , 2004, Journal of biomedical optics.

[19]  S. Lam,et al.  Near‐infrared Raman spectroscopy for optical diagnosis of lung cancer , 2003, International journal of cancer.

[20]  H. Lui,et al.  Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx—preliminary findings , 2003, Lasers in surgery and medicine.

[21]  R. Dasari,et al.  Identifying microcalcifications in benign and malignant breast lesions by probing differences in their chemical composition using Raman spectroscopy. , 2002, Cancer research.

[22]  J. Sudbø,et al.  Retracted: Comparison of histological grading and large‐scale genomic status (DNA ploidy) as prognostic tools in oral dysplasia , 2001, The Journal of pathology.

[23]  H. Barr,et al.  Raman Spectroscopy for Early Detection of Laryngeal Malignancy: Preliminary Results , 2000, The Laryngoscope.

[24]  Brian C. Wilson,et al.  In vivo Near-infrared Raman Spectroscopy: Demonstration of Feasibility During Clinical Gastrointestinal Endoscopy¶ , 2000, Photochemistry and photobiology.

[25]  Gerwin J. Puppels,et al.  Progress in the detection of neoplastic progress and cancer by Raman spectroscopy , 2000, BiOS.

[26]  Anita Mahadevan-Jansen,et al.  Diagnostic tool for early detection of ovarian cancers using Raman spectroscopy , 2000, BiOS.

[27]  R. Dasari,et al.  Prospects for in vivo Raman spectroscopy. , 2000, Physics in medicine and biology.

[28]  Brian C. Wilson,et al.  Study of Fiber-Optic Probes for in vivo Medical Raman Spectroscopy , 1999 .

[29]  John B. Cooper,et al.  Chemometric analysis of Raman spectroscopic data for process control applications , 1999 .

[30]  A. Mahadevan-Jansen,et al.  Near‐Infrared Raman Spectroscopy for In Vitro Detection of Cervical Precancers , 1998 .

[31]  M. Feld,et al.  Raman Spectroscopy and Fluorescence Photon Migration for Breast Cancer Diagnosis and Imaging , 1998, Photochemistry and photobiology.

[32]  H. Wulf,et al.  Distinctive Molecular Abnormalities in Benign and Malignant Skin Lesions: Studies by Raman Spectroscopy , 1997, Photochemistry and photobiology.

[33]  R. Richards-Kortum,et al.  Raman spectroscopy for the detection of cancers and precancers. , 1996, Journal of biomedical optics.

[34]  A Mashberg,et al.  Early diagnosis of asymptomatic oral and oropharyngeal squamouscancers , 1995, CA: a cancer journal for clinicians.

[35]  E. Eisenberg,et al.  Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia. , 1995, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[36]  A. Karabulut,et al.  Observer variability in the histologic assessment of oral premalignant lesions. , 1995, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[37]  Yukihiro Ozaki,et al.  Near‐infrared Fourier transform Raman spectroscopic study of human brain tissues and tumours , 1994 .

[38]  R. Alfano,et al.  Raman, fluorescence, and time-resolved light scattering as optical diagnostic techniques to separate diseased and normal biomedical media. , 1992, Journal of photochemistry and photobiology. B, Biology.

[39]  J. Schnetler.  Oral cancer diagnosis and delays in referral. , 1992, The British journal of oral & maxillofacial surgery.

[40]  R. Alfano,et al.  Human breast tissues studied by IR Fourier-transform Raman spectroscopy , 1991 .

[41]  K. S. Krishnan,et al.  A New Type of Secondary Radiation , 1928, Nature.