A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

[1]  P. Lipsky,et al.  Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-61 , 2004, The Journal of Immunology.

[2]  A. Coyle,et al.  Expression of the SH2D1A gene is regulated by a combination of transcriptional and post‐transcriptional mechanisms , 2004, European journal of immunology.

[3]  T. Dörner,et al.  Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus. , 2004, Arthritis and rheumatism.

[4]  E. Butcher,et al.  Unique gene expression program of human germinal center T helper cells. , 2004, Blood.

[5]  J. Penninger,et al.  Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. , 2004, Immunity.

[6]  V. Kuchroo,et al.  The Diabetes Susceptibility Locus Idd5.1 on Mouse Chromosome 1 Regulates ICOS Expression and Modulates Murine Experimental Autoimmune Encephalomyelitis 1 , 2004, The Journal of Immunology.

[7]  C. Mackay,et al.  T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells1 , 2004, The Journal of Immunology.

[8]  S. Goldenberg,et al.  TcZFP1: a CCCH zinc finger protein of Trypanosoma cruzi that binds poly-C oligoribonucleotides in vitro. , 2004, Biochemical and biophysical research communications.

[9]  N. Sarvetnick,et al.  Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity , 2004, Cell.

[10]  H. Dyson,et al.  Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d , 2004, Nature Structural &Molecular Biology.

[11]  J. Cambier,et al.  B lymphocyte activation during cognate interactions with CD4+ T lymphocytes: molecular dynamics and immunologic consequences. , 2003, Seminars in immunology.

[12]  N. Miyasaka,et al.  Involvement of Inducible Costimulator-B7 Homologous Protein Costimulatory Pathway in Murine Lupus Nephritis 1 , 2003, The Journal of Immunology.

[13]  C. Ng,et al.  Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2. , 2003, Blood.

[14]  U. Eriksson,et al.  Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses , 2003, Nature Immunology.

[15]  J. Penninger,et al.  Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. , 2003, Immunity.

[16]  M. Wickens,et al.  A Place to Die, a Place to Sleep , 2003, Science.

[17]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[18]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[19]  A. Schäffer,et al.  Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency , 2003, Nature Immunology.

[20]  Andreas Radbruch,et al.  Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10 , 2003, The Journal of experimental medicine.

[21]  D. Gray,et al.  T Cell Accumulation in B Cell Follicles Is Regulated by Dendritic Cells and Is Independent of B Cell Activation , 2003, The Journal of experimental medicine.

[22]  R. Ahmed,et al.  SAP is required for generating long-term humoral immunity , 2003, Nature.

[23]  A. Sher,et al.  A Critical Role for IL-21 in Regulating Immunoglobulin Production , 2002, Science.

[24]  C. Goodnow,et al.  Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes , 2002, The Journal of experimental medicine.

[25]  P. Loetscher,et al.  CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses. , 2002, Trends in immunology.

[26]  S. Elledge,et al.  Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex , 2002, Nature.

[27]  A. Strasser,et al.  BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes , 2002, Nature.

[28]  P. Blackshear Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover. , 2001, Biochemical Society transactions.

[29]  T. Behrens,et al.  Delineating the genetic basis of systemic lupus erythematosus. , 2001, Immunity.

[30]  R. Flavell,et al.  Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions1 , 2001, The Journal of Immunology.

[31]  J. Allison,et al.  ICOS co-stimulatory receptor is essential for T-cell activation and function , 2001, Nature.

[32]  T. Pawson,et al.  ICOS is essential for effective T-helper-cell responses , 2001, Nature.

[33]  G. Freeman,et al.  ICOS is critical for CD40-mediated antibody class switching , 2001, Nature.

[34]  Scott R. Presnell,et al.  Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function , 2000, Nature.

[35]  Ping Wang,et al.  Structure of a c-Cbl–UbcH7 Complex RING Domain Function in Ubiquitin-Protein Ligases , 2000, Cell.

[36]  W. Keller,et al.  Distinct roles of two Yth1p domains in 3′‐end cleavage and polyadenylation of yeast pre‐mRNAs , 2000, The EMBO journal.

[37]  P. Lane,et al.  Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. , 2000, Immunology today.

[38]  E. Shevach,et al.  Cbl-b regulates the CD28 dependence of T-cell activation , 2000, Nature.

[39]  T. Mak,et al.  T-cell co-stimulation through B7RP-1 and ICOS , 1999, Nature.

[40]  M. Riedinger,et al.  CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40‐ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles , 1999, European journal of immunology.

[41]  R. Cuesta,et al.  Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. , 1999, Science.

[42]  Andreas Hutloff,et al.  ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 , 1999, Nature.

[43]  K. Toellner,et al.  T Helper 1 (th1) and Th2 Characteristics Start to Develop during T Cell Priming and Are Associated with an Immediate Ability to Induce Immunoglobulin Class Switching , 1998 .

[44]  M. Davis,et al.  A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. , 1997, Immunity.

[45]  P. Marrack,et al.  The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire , 1995, The Journal of experimental medicine.

[46]  D. Loh,et al.  Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. , 1994, Immunity.

[47]  L. Peltonen,et al.  Aire regulates negative selection of organ-specific T cells , 2003, Nature Immunology.

[48]  P. Anderson,et al.  Stressful initiations. , 2002, Journal of cell science.

[49]  L. Glimcher,et al.  NFATc1 and NFATc2 together control both T and B cell activation and differentiation. , 2001, Immunity.