Alteration of cartilagenous proteoglycan in psoriasis

Articular tissue was obtained at surgery for a femoral neck fracture in a patient with psoriasis without arthritis. The proteoglycan of the cartilage of the sample was analysed biochemically. Normal cartilage is known to produce two types of proteoglycan monomers (fast‐ and slow‐sedimenting groups), which are distinguishable by density‐gradient ultracentrifugation. In the psoriatic cartilage analysed in the present study, it was shown that the former group was absent and only the latter group remained.

[1]  Y. Nozawa,et al.  Increased protein kinase C activity in fibroblast membranes from psoriatic patients. , 1988, The Journal of investigative dermatology.

[2]  M. Takigawa,et al.  Differential effects of parathyroid hormone and somatomedin-like growth factors on the sizes of proteoglycan monomers and their synthesis in rabbit costal chondrocytes in culture. , 1985, Biochimica et biophysica acta.

[3]  M. Takigawa,et al.  Differentiation and de-differentiation of cultured chondrocytes: increase in monomeric size of 'cartilage-specific' proteoglycans by dibutyryl cyclic AMP and complete inhibition of their synthesis by retinoic acid. , 1985, Biochemistry international.

[4]  G. Priestley.  Hyperactivity of fibroblasts cultured from psoriatic skin: II. Synthesis of macromolecules , 1983, The British journal of dermatology.

[5]  L. W. Adams,et al.  Hyperactivity of fibroblasts cultured from psoriatic skin: I. Faster proliferation and effect of serum withdrawal , 1983, The British journal of dermatology.

[6]  L. W. Adams,et al.  Proliferative responses of fibroblasts from psoriatic and normal skin to clobetasol propionate. , 1983, Acta dermato-venereologica.

[7]  L. Rosenthall,et al.  Periarticular uptake of 99mtechnetium diphosphonate in psoriatics: correlation with cutaneous activity. , 1976, Arthritis and rheumatism.

[8]  H. Little,et al.  Psoriatic arthritis in severe psoriasis. , 1975, Canadian Medical Association journal.

[9]  A. Eisen,et al.  A sensitive microassay for prolyl hydroxylase: activity in normal and psoriatic skin. , 1973, The Journal of investigative dermatology.

[10]  E. Tábora,et al.  Alterations of collagen in psoriatic skin. , 1972, Dermatologica.

[11]  R. Fleischmajer,et al.  Fractionation of glycosaminoglycans from psoriatic skin. , 1970, The Journal of investigative dermatology.

[12]  R. Brunish,et al.  Urinary Excretion of Acid Mucopolysaccharides and Hydroxyproline in Psoriasis , 1965 .