Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha.

[1]  S. Bonner-Weir,et al.  The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. , 1999, Diabetes.

[2]  R. Schmid,et al.  Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice. , 1998, Gastroenterology.

[3]  C. Wright,et al.  Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Stein,et al.  Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene , 1997, Molecular and cellular biology.

[5]  R. Balling,et al.  Pax genes and organogenesis , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[6]  M. G. Lee,et al.  Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells. , 1997, The American journal of physiology.

[7]  M. German,et al.  Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. , 1997, Genes & development.

[8]  J. Rehfeld,et al.  Expression of gastrin and transforming growth factor-α during duct to islet cell differentiation in the pancreas of duct-ligated adult rats , 1997, Diabetologia.

[9]  M. C. Jørgensen,et al.  Transcription factors contributing to the pancreatic beta-cell phenotype. , 1997, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[10]  P. Gruss,et al.  Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas , 1997, Nature.

[11]  M. German,et al.  The β cell transcription factors and development of the pancreas , 1997, Journal of Molecular Medicine.

[12]  A. Cooke,et al.  α-Cell Neogenesis in an Animal Model of IDDM , 1997, Diabetes.

[13]  R. Stein,et al.  Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. , 1997, Endocrinology.

[14]  William L. Clarke,et al.  Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence , 1997, Nature Genetics.

[15]  O. Sundin,et al.  The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia. , 1997, Investigative ophthalmology & visual science.

[16]  B. Hogan,et al.  PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. , 1996, Development.

[17]  P. Pour,et al.  The role of pancreatic islets in experimental pancreatic carcinogenicity. , 1995, The American journal of pathology.

[18]  J. Slack.  Developmental biology of the pancreas. , 1995, Development.

[19]  R. Stein,et al.  Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. , 1995, Development.

[20]  H. Edlund,et al.  Insulin-promoter-factor 1 is required for pancreas development in mice , 1994, Nature.

[21]  F. Radvanyi,et al.  Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells. , 1994, Molecular endocrinology.

[22]  L. Baxter,et al.  A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development , 1993, Diabetes.

[23]  E. Schmidt,et al.  Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. , 1993, The Journal of clinical investigation.

[24]  P. Gruss,et al.  The oncogenic potential of Pax genes. , 1993, The EMBO journal.

[25]  N. Sarvetnick,et al.  Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. , 1993, Development.

[26]  G. Merlino,et al.  Cytological changes in the pancreas of transgenic mice overexpressing transforming growth factor alpha. , 1992, Gastroenterology.

[27]  R. Coffey,et al.  Possible role of transforming growth factor alpha in the pathogenesis of Ménétrier's disease: supportive evidence form humans and transgenic mice. , 1992, Gastroenterology.

[28]  I. Ihse,et al.  The importance of the centroacinar region in cerulein-induced mouse pancreatic growth. , 1992, Scandinavian journal of gastroenterology.

[29]  G. Merlino,et al.  TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas , 1990, Cell.

[30]  R. Palmiter,et al.  Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast , 1990, Cell.

[31]  S. Githens.  The pancreatic duct cell: proliferative capabilities, specific characteristics, metaplasia, isolation, and culture. , 1988, Journal of pediatric gastroenterology and nutrition.

[32]  A. Vinik,et al.  Induction of Nesidioblastosis Will Reverse Diabetes in Syrian Golden Hamster , 1988, Diabetes.

[33]  P. Pour.  Cell differentiation during pancreatic carcinogenesis. , 1988, Scandinavian journal of gastroenterology. Supplement.

[34]  G. Teitelman,et al.  Cell lineage analysis of pancreatic islet development: glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct. , 1987, Developmental biology.

[35]  P. Pour,et al.  Ductal metaplasia of human exocrine pancreas and its association with carcinoma. , 1985, Cancer research.