Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation

[1]  K. Rosengren,et al.  Circular Proteins from Plants and Fungi* , 2012, The Journal of Biological Chemistry.

[2]  Julie H. Campbell,et al.  Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. , 2011, Blood.

[3]  D. Craik,et al.  Engineering of conotoxins for the treatment of pain. , 2011, Current pharmaceutical design.

[4]  J. Ottesen,et al.  A Reversible Protection Strategy To Improve Fmoc‐SPPS of Peptide Thioesters by the N‐Acylurea Approach , 2011, Chembiochem : a European journal of chemical biology.

[5]  A. Cole,et al.  Retrocyclins and their activity against HIV-1 , 2011, Cellular and Molecular Life Sciences.

[6]  Cyril F. Reboul,et al.  Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network , 2011, PloS one.

[7]  O. Seitz,et al.  9-Fluorenylmethoxycarbonyl-based solid-phase synthesis of peptide α-thioesters. , 2011, Angewandte Chemie.

[8]  D. Craik,et al.  Interlocking disulfides in circular proteins: toward efficient oxidative folding of cyclotides. , 2011, Antioxidants & redox signaling.

[9]  D. Craik,et al.  Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization. , 2011, Antioxidants & redox signaling.

[10]  D. Andersson,et al.  The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria. , 2010, The Journal of antimicrobial chemotherapy.

[11]  Sungkyun Park,et al.  An Efficient Approach for the Total Synthesis of Cyclotides by Microwave Assisted Fmoc-SPPS , 2010, International Journal of Peptide Research and Therapeutics.

[12]  David J Craik,et al.  The engineering of an orally active conotoxin for the treatment of neuropathic pain. , 2010, Angewandte Chemie.

[13]  R. Liskamp,et al.  Synthesis and structural characterization of all four diastereoisomers of the crossed alkene-bridged nisin DE-ring mimic , 2010 .

[14]  David J Craik,et al.  Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins. , 2010, Biopolymers.

[15]  U. Haberkorn,et al.  Sunflower Trypsin Inhibitor 1 Derivatives as Molecular Scaffolds for the Development of Novel Peptidic Radiopharmaceuticals , 2010, Molecular Imaging and Biology.

[16]  E. Tate,et al.  Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold. , 2009, Journal of medicinal chemistry.

[17]  Judit Tulla-Puche,et al.  Optimized Fmoc solid‐phase synthesis of Thymosin α1 by side‐chain anchoring onto a PEG resin , 2009, Biopolymers.

[18]  D. Craik,et al.  Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides. , 2008, Journal of medicinal chemistry.

[19]  K. Sletten,et al.  Cyclic Peptides from Oldenlandia affinis DC. Molecular and Biological Properties , 2008, Chemistry & biodiversity.

[20]  O. Seitz,et al.  Native chemical ligation at valine. , 2008, Angewandte Chemie.

[21]  P. Dawson,et al.  An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation. , 2008, Angewandte Chemie.

[22]  E. Tate,et al.  Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides. , 2008, Organic & biomolecular chemistry.

[23]  Conan K. L. Wang,et al.  CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering , 2007, Nucleic Acids Res..

[24]  D. Craik,et al.  Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. , 2008, Chembiochem : a European journal of chemical biology.

[25]  S. Danishefsky,et al.  Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. , 2007, Angewandte Chemie.

[26]  Norelle L Daly,et al.  The Absolute Structural Requirement for a Proline in the P3′-position of Bowman-Birk Protease Inhibitors Is Surmounted in the Minimized SFTI-1 Scaffold* , 2006, Journal of Biological Chemistry.

[27]  Edward W. Tate,et al.  Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II. , 2006, Chemical communications.

[28]  K. Gustafson,et al.  Anti-HIV cyclotides. , 2004, Current protein & peptide science.

[29]  L. Bohlin,et al.  Cytotoxic cyclotides from Viola tricolor. , 2004, Journal of natural products.

[30]  A. Lönneborg,et al.  Isolation and characterization of a cDNA encoding a plant defensin-like protein from roots of Norway spruce , 1996, Plant Molecular Biology.

[31]  D. Craik,et al.  Disulfide Folding Pathways of Cystine Knot Proteins , 2003, The Journal of Biological Chemistry.

[32]  E. Gerner,et al.  Selenomethionine Inhibits Growth and Suppresses Cyclooxygenase-2 (COX-2) Protein Expression in Human Colon Cancer Cell Lines , 2002, Cancer biology & therapy.

[33]  A. Jaśkiewicz,et al.  Chemical synthesis and kinetic study of the smallest naturally occurring trypsin inhibitor SFTI-1 isolated from sunflower seeds and its analogues. , 2002, Biochemical and biophysical research communications.

[34]  A. Backlund,et al.  Cyclotides: a novel type of cytotoxic agents. , 2002, Molecular cancer therapeutics.

[35]  I. Enyedy,et al.  Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase. , 2001, Bioorganic & medicinal chemistry letters.

[36]  Clement Waine,et al.  Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[37]  D. Craik,et al.  Solution structures by 1H NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant. , 2001, Journal of molecular biology.

[38]  D. Clapham,et al.  Identification of candidate genes for use in molecular breeding - A case study with the Norway spruce defensin-like gene, SPI 1 , 2001 .

[39]  A. Clippingdale,et al.  Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation , 2000, Journal of peptide science : an official publication of the European Peptide Society.

[40]  D. Craik,et al.  Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. , 1999, Journal of molecular biology.

[41]  J. Griffin,et al.  Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[42]  S Luckett,et al.  High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds. , 1999, Journal of molecular biology.

[43]  L. Juliano,et al.  Studies on lactam formation during coupling procedures of N alpha-N omega-protected arginine derivatives. , 1996, Peptide research.

[44]  T. Muir,et al.  Synthesis of proteins by native chemical ligation. , 1994, Science.

[45]  R. B. Merrifield,et al.  Mechanisms of aspartimide formation: the effects of protecting groups, acid, base, temperature and time. , 1988, Peptide research.

[46]  R. Sheppard,et al.  The safety catch principle in solid phase peptide synthesis , 1971 .