ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.
暂无分享,去创建一个
W. Wahli | H. Guillou | F. Lasserre | R. Métivier | Y. Lippi | D. Langin | P. Gourdy | A. Polizzi | F. Benhamed | C. Postic | A. Fougerat | M. Schupp | A. Lass | T. Levade | C. Jouffe | Delphine Meynard | F. Greulich | E. Amri | M. Régnier | N. Loiseau | S. Smati | B. Tramunt | A. Montagner | Gabriele Schoiswohl | G. Panasyuk | L. Gamet-Payrastre | Patricia Dubot | Carina Wagner | S. Ellero-Simatos | C. Cruciani-Guglielmacci | Chantal Alkhoury | C. Sommer | T. Fougeray | Ilyès Raho | Valentine Melin | Anthony Emile | Henriette Uhlenhaut
[1] A. Reinisch,et al. Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism , 2022, Science advances.
[2] E. Selen,et al. Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease , 2021, JCI insight.
[3] G. Shulman,et al. A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21 , 2020, Genes & development.
[4] R. Zechner,et al. Adipose Triglyceride Lipase is needed for homeostatic control of Sterol Element-Binding Protein-1c driven hepatic lipogenesis , 2020, bioRxiv.
[5] T. Walther,et al. Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis , 2020, bioRxiv.
[6] W. Wahli,et al. Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-α and insulin-dependent signalling in hepatocytes. , 2020, Diabetes & metabolism.
[7] Kohske Takahashi,et al. Welcome to the Tidyverse , 2019, J. Open Source Softw..
[8] L. Linares,et al. Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer , 2019, Molecular metabolism.
[9] G. Van den Berghe,et al. Hepatic PPARα is critical in the metabolic adaptation to sepsis. , 2019, Journal of hepatology.
[10] Olga Tanaseichuk,et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets , 2019, Nature Communications.
[11] S. Kliewer,et al. A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21. , 2019, Cell metabolism.
[12] Matthew J. Potthoff,et al. Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure , 2019, Scientific Reports.
[13] Damian Szklarczyk,et al. STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets , 2018, Nucleic Acids Res..
[14] A. Kurisaki,et al. Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine. , 2018, Cell reports.
[15] R. Zechner,et al. Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice. , 2018, Cell metabolism.
[16] M. Klingenspor,et al. Brown adipocyte glucose metabolism: a heated subject , 2018, EMBO reports.
[17] W. Wahli,et al. Insights into the role of hepatocyte PPARα activity in response to fasting , 2017, Molecular and Cellular Endocrinology.
[18] C. Diwoky,et al. Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue , 2017, Cell metabolism.
[19] O. Gavrilova,et al. Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice. , 2017, Cell metabolism.
[20] W. Wahli,et al. A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response , 2017, Cell reports.
[21] S. Imbeaud,et al. Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. , 2017, Journal of hepatology.
[22] R. Zechner,et al. Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. , 2017, Cell metabolism.
[23] J. Zucman‐Rossi,et al. Hepatocyte nuclear factor 1&agr; suppresses steatosis-associated liver cancer by inhibiting PPAR&ggr; transcription , 2017, The Journal of clinical investigation.
[24] T. Schulz,et al. Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[25] John Quackenbush,et al. Smooth Quantile Normalization , 2016, bioRxiv.
[26] W. Wahli,et al. Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids , 2016, International journal of molecular sciences.
[27] W. Wahli,et al. Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD , 2016, Gut.
[28] Richard D. Smith,et al. SerpinB1 Promotes Pancreatic β Cell Proliferation. , 2016, Cell metabolism.
[29] I. Goldstein,et al. Transcriptional and Chromatin Regulation during Fasting – The Genomic Era , 2015, Trends in Endocrinology & Metabolism.
[30] J. Auwerx,et al. Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice , 2015, Hepatology.
[31] K. Guan,et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling , 2015, Nature Communications.
[32] R. Zechner,et al. Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids , 2015, Journal of hepatology.
[33] D. Stolz,et al. Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice. , 2015, Endocrinology.
[34] Raphael Gottardo,et al. Orchestrating high-throughput genomic analysis with Bioconductor , 2015, Nature Methods.
[35] Matthew E. Ritchie,et al. limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.
[36] A. Doria,et al. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. , 2015, Cell metabolism.
[37] S. Kliewer,et al. Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding , 2014, Diabetes.
[38] B. Staels,et al. The transrepressive activity of peroxisome proliferator‐activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice , 2014, Hepatology.
[39] R. MacPherson,et al. Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice. , 2014, American journal of physiology. Endocrinology and metabolism.
[40] TL Jensen,et al. Fasting of mice: a review , 2013, Laboratory animals.
[41] KyeongJin Kim,et al. S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator‐activated receptor alpha activity in the liver , 2012, Hepatology.
[42] B. Spiegelman,et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. , 2012, Genes & development.
[43] D. Sabatini,et al. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing , 2010, Nature.
[44] Frans Voorbraak,et al. Bias in the Cq value observed with hydrolysis probe based quantitative PCR can be corrected with the estimated PCR efficiency value. , 2010, Methods.
[45] F. Villarroya,et al. Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. , 2010, Cell metabolism.
[46] L. Sanderson,et al. Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver , 2009, Molecular and Cellular Biology.
[47] John Turk,et al. Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver , 2009, Cell.
[48] A. Moorman,et al. Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data , 2009, Nucleic acids research.
[49] J. Flier,et al. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. , 2007, Cell metabolism.
[50] S. Kliewer,et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. , 2007, Cell metabolism.
[51] Michael Schuler,et al. PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes , 2006 .
[52] J. Gromada,et al. Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways , 2006, Diabetes.
[53] E. Wagner,et al. Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase , 2006, Science.
[54] J. Schneider,et al. "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. , 2005, Cell metabolism.
[55] T. Mak,et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. , 2004, The Journal of clinical investigation.
[56] Masataka Harada,et al. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 , 2003, Nature.
[57] W. Wahli,et al. Peroxisome proliferator-activated receptors: nuclear control of metabolism. , 1999, Endocrine reviews.
[58] W. Wahli,et al. Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting , 1999 .
[59] D. Chace,et al. Rapid diagnosis of MCAD deficiency: quantitative analysis of octanoylcarnitine and other acylcarnitines in newborn blood spots by tandem mass spectrometry. , 1997, Clinical chemistry.
[60] B. Lowell,et al. β3-Adrenergic Receptors on White and Brown Adipocytes Mediate β3-Selective Agonist-induced Effects on Energy Expenditure, Insulin Secretion, and Food Intake , 1997, The Journal of Biological Chemistry.
[61] Y. Benjamini,et al. Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .
[62] T. Hiroshige,et al. Role of ketone bodies in nonshivering thermogenesis in cold-acclimated rats. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.