Sleep deprivation and phasic activity of REM sleep: independence of middle-ear muscle activity from rapid eye movements.

In the recovery nights after total and partial sleep deprivation there is a reduction of rapid eye movements during REM sleep as compared to baseline nights; recent evidence provided by a selective SWS deprivation study also shows that the highest percentage of variance of this reduction is explained by SWS rebound. The present study assesses whether the reduction of rapid eye movements (REMs) during the recovery night after total sleep deprivation is paralleled by a decrease of middle-ear muscle activity (MEMA), another phasic muscle activity of REM sleep. Standard polysomnography, MEMA and REMs of nine subjects were recorded for three nights (one adaptation, one baseline, one recovery); baseline and recovery night were separated by a period of 40 hours of continuous wake. Results show that, in the recovery night, sleep deprivation was effective in determining an increase of SWS amount and of the sleep efficiency index, and a decrease of stage 1, stage 2, intra-sleep wake, and NREM latencies, without affecting REM duration and latency. However, MEMA frequency during REM sleep did not diminish during these nights as compared to baseline ones, while there was a clear effect of REM frequency reduction. Results indicate an independence of phasic events of REM sleep, suggesting that the inverse relation between recovery sleep after sleep deprivation and REM frequency is not paralleled by a concomitant variation in MEMA frequency.

[1]  R. Stafford,et al.  Principles and Practice of Sleep Medicine , 2001 .

[2]  M. Ferrara,et al.  Sleepiness, alertness and performance during a laboratory simulation of an acute shift of the wake-sleep cycle. , 1998, Ergonomics.

[3]  S. Sato,et al.  Relationship between muscle tone changes, sawtooth waves and rapid eye movements during sleep. , 1997, Electroencephalography and clinical neurophysiology.

[4]  K. Takahashi,et al.  Precise measurement of individual rapid eye movements in REM sleep of humans. , 1997, Sleep.

[5]  F. Lucidi,et al.  Rapid eye movements density as a measure of sleep need: REM density decreases linearly with the reduction of prior sleep duration. , 1996, Electroencephalography and clinical neurophysiology.

[6]  L. Sanford,et al.  Stimulus-elicited behavior in rapid eye movement sleep without atonia. , 1995, Behavioral neuroscience.

[7]  V. Zarcone,et al.  Middle ear muscle activity (MEMA) in schizophrenia using a noninvasive technique. , 1995, Sleep.

[8]  J. Csernansky,et al.  The effect of chronic alprazolam on sleep and bioamine metabolites in depression. , 1994, Journal of clinical psychopharmacology.

[9]  V. Zarcone,et al.  An inexpensive alternative for recording middle ear muscle activity (MEMA) during sleep. , 1992, Sleep.

[10]  V P Zarcone,et al.  Middle-ear muscle activity (MEMA) and its association with motor activity in the extremities and head in sleep. , 1991, Sleep.

[11]  I. Feinberg,et al.  Acute deprivation of the terminal four hours of sleep does not increase delta (0-3-Hz) electroencephalograms: a replication. , 1991, Sleep.

[12]  M. Kryger,et al.  Principles And Practice Of Sleep Medicine , 1989 .

[13]  I. Feinberg,et al.  Response of delta (0-3 Hz) EEG and eye movement density to a night with 100 minutes of sleep. , 1988, Sleep.

[14]  P. Geisler,et al.  Rapid eye movements, muscle twitches and sawtooth waves in the sleep of narcoleptic patients and controls. , 1987, Electroencephalography and clinical neurophysiology.

[15]  I. Feinberg,et al.  Effects of sleep loss on delta (0.3-3 Hz) EEG and eye movement density: new observations and hypotheses. , 1987, Electroencephalography and clinical neurophysiology.

[16]  D J Kupfer,et al.  Sleep research in affective illness: state of the art circa 1987. , 1987, Sleep.

[17]  I. Degrell.  Treatment of psychopathology in the aging , 1983 .

[18]  G. Fein,et al.  EEG patterns during and following extended sleep in young adults. , 1980, Electroencephalography and clinical neurophysiology.

[19]  E. Aserinsky,et al.  Relationship of rapid eye movement density to the prior accumulation of sleep and wakefulness. , 1973, Psychophysiology.

[20]  H. Roffwarg,et al.  Spontaneous Middle Ear Muscle Activity in Man: A Rapid Eye Movement Sleep Phenomenon , 1972, Science.

[21]  P. Salzarulo,et al.  Variations with time of the quantity of eye movements during fast sleep in man. , 1972, Electroencephalography and clinical neurophysiology.

[22]  E. Wolpert.  A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. , 1969 .

[23]  W. Bunney,et al.  Biological markers in depression. , 1986, Psychopathology.

[24]  V. Zarcone,et al.  Phasic events of REM sleep: phenomenology of middle ear muscle activity and periorbital integrated potentials in the same normal population. , 1979, Sleep.