Bloch long-range surface plasmons on waveguide arrays as multichannel biosensors

Novel, cost-effective and label-free Bloch surface plasmon biosensors are presented in this work. The biosensor chip consists of Au waveguides on a truncated 1D photonic crystal supporting Bloch long range surface plasmons (LRSPs) to form an optical biosensor. Gratings capable of coupling perpendicularly incident Gaussian beams are employed as the input-output means. The waveguides are covered with a low index fluoropolymer, etched to form the microfluidic channels and wafer bonded to seal and enable side fluidic interfaces. The devices are fabricated using wafer-scale processes and are capable of multichannel multimodal biosensing. Similar sensitivities to LRSPPs in the corresponding fluoropolymer/solution system are expected with Bloch LRSPPs.

[1]  V. Konopsky,et al.  Photonic crystal surface waves for optical biosensing , 2007, 2011 International Workshop on Biophotonics.

[2]  P. Berini,et al.  Grating couplers fabricated by e-beam lithography for long-range surface plasmon waveguides embedded in a fluoropolymer. , 2019, Applied optics.

[3]  J. Sipe,et al.  Long-range surface plasmons in multilayer structures , 2013, 1307.4353.

[4]  D. Van Thourhout,et al.  Compact Focusing Grating Couplers for Silicon-on-Insulator Integrated Circuits , 2007, IEEE Photonics Technology Letters.

[5]  Eli Yablonovitch,et al.  Numerical optimization of a grating coupler for the efficient excitation of surface plasmons at an Ag-SiO 2 interface , 2007, physics/0703036.

[6]  Characterization of grating-coupled long range surface plasmon polariton membrane waveguides. , 2015, Optics express.

[7]  Wei Ru Wong,et al.  Detection of dengue NS1 antigen using long-range surface plasmon waveguides. , 2016, Biosensors & bioelectronics.

[8]  Pierre Berini,et al.  Biomolecular kinetics analysis using long-range surface plasmon waveguides , 2017 .

[9]  Q. Gong,et al.  Efficient Unidirectional Launching of Surface Plasmons by Multi-Groove Structures , 2017, Plasmonics.

[10]  Pierre Berini,et al.  Grating couplers for broadside input and output coupling of long-range surface plasmons. , 2010, Optics express.

[11]  Siegfried Janz,et al.  Waveguide subwavelength structures : a review of principles and applications , 2014 .

[12]  V. Konopsky,et al.  Ultralong-range propagation of plasmon-polaritons in a thin metal film on a one-dimensional photonic crystal surface , 2006, 2007 European Conference on Lasers and Electro-Optics and the International Quantum Electronics Conference.

[13]  J. Homola Surface plasmon resonance sensors for detection of chemical and biological species. , 2008, Chemical reviews.

[14]  Sergey I. Bozhevolnyi,et al.  Efficiency of local surface plasmon polariton excitation on ridges , 2008, SPIE Photonics Europe.

[15]  J. Homola Present and future of surface plasmon resonance biosensors , 2003, Analytical and bioanalytical chemistry.

[16]  P. Berini,et al.  Low detection limits using sandwich and inhibition assays on long-range surface plasmon waveguide biosensors , 2018, Sensors and Actuators B: Chemical.

[17]  P. Berini Long-range surface plasmon polaritons , 2009 .

[18]  X. D. Hoa,et al.  Towards integrated and sensitive surface plasmon resonance biosensors: a review of recent progress. , 2007, Biosensors & bioelectronics.

[19]  A Bräuer,et al.  Efficient coupling into polymer waveguides by gratings. , 1997, Applied optics.

[20]  P. Berini,et al.  Grating couplers for (Bloch) long-range surface plasmons on metal stripe waveguides , 2019, Journal of the Optical Society of America B.

[21]  Tsuyoshi Nomura,et al.  Topology optimization of grating couplers for the efficient excitation of surface plasmons , 2010 .