The juxtamembrane wedge negatively regulates CD45 function in B cells.

[1]  H. Nam,et al.  Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45 , 2005, The Journal of experimental medicine.

[2]  P. Borrow,et al.  Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. , 2004, International immunology.

[3]  N. Huntington,et al.  CD45: direct and indirect government of immune regulation. , 2004, Immunology letters.

[4]  C. Lowell.  Src-family kinases: rheostats of immune cell signaling. , 2004, Molecular immunology.

[5]  N. Rajewsky,et al.  Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer , 2004, Cell.

[6]  J. Monroe.  Ligand-independent tonic signaling in B-cell receptor function. , 2004, Current opinion in immunology.

[7]  M. Ogimoto,et al.  Dynamic regulation of Src-family kinases by CD45 in B cells. , 2004, Blood.

[8]  S. Pillai,et al.  Positive selection and lineage commitment during peripheral B‐lymphocyte development , 2004, Immunological reviews.

[9]  M. Hermiston,et al.  CD45: a critical regulator of signaling thresholds in immune cells. , 2003, Annual review of immunology.

[10]  D. Alexander,et al.  Either of the CD45RB and CD45RO Isoforms Are Effective in Restoring T Cell, But Not B Cell, Development and Function in CD45-Null Mice1 , 2003, The Journal of Immunology.

[11]  S. Akira,et al.  CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. , 2003, Blood.

[12]  J. den Hertog,et al.  Redox-regulated Rotational Coupling of Receptor Protein-tyrosine Phosphatase α Dimers* , 2003, The Journal of Biological Chemistry.

[13]  A. DeFranco,et al.  Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. , 2003, Molecular biology of the cell.

[14]  C. Quilici,et al.  Sustained Activation of Lyn Tyrosine Kinase In Vivo Leads to Autoimmunity , 2002, The Journal of experimental medicine.

[15]  H. Niiro,et al.  Decision making in the immune system: Regulation of B-cell fate by antigen-receptor signals , 2002, Nature Reviews Immunology.

[16]  A. Weiss,et al.  Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms , 2002, Nature Immunology.

[17]  D. Alexander,et al.  Differential Association of CD45 Isoforms with CD4 and CD8 Regulates the Actions of Specific Pools of p56lck Tyrosine Kinase in T Cell Antigen Receptor Signal Transduction* , 2002, The Journal of Biological Chemistry.

[18]  S. Latour,et al.  Negative regulation of immunoreceptor signaling. , 2002, Annual review of immunology.

[19]  K. Wucherpfennig,et al.  Mechanisms for the induction of autoimmunity by infectious agents. , 2001, The Journal of clinical investigation.

[20]  T. Hunter,et al.  Dimerization of Receptor Protein-Tyrosine Phosphatase alpha in living cells , 2001, BMC Cell Biology.

[21]  R. Majeti,et al.  An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity , 2000, Cell.

[22]  M. Mullan,et al.  CD45 Inhibits CD40L-induced Microglial Activation via Negative Regulation of the Src/p44/42 MAPK Pathway* , 2000, The Journal of Biological Chemistry.

[23]  T. Chatila,et al.  Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease , 2000, Nature Medicine.

[24]  J. Ashwell,et al.  CD45 and Src-family kinases: and now for something completely different. , 1999, Immunology today.

[25]  E. Brown,et al.  Positive and negative regulation of Src-family membrane kinases by CD45. , 1999, Immunology today.

[26]  K. Rajewsky,et al.  B Cell Antigen Receptor Specificity and Surface Density Together Determine B-1 versus B-2 Cell Development , 1999, The Journal of experimental medicine.

[27]  P. Johnson,et al.  Characterization of Recombinant CD45 Cytoplasmic Domain Proteins , 1998, The Journal of Biological Chemistry.

[28]  J. Cyster,et al.  Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. , 1998, Immunity.

[29]  J. Noel,et al.  Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. , 1998, Science.

[30]  Philippe Soriano,et al.  Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. , 1997, Immunity.

[31]  M. Neuberger,et al.  Hyperresponsive B Cells in CD22-Deficient Mice , 1996, Science.

[32]  J. Noel,et al.  Structural basis for inhibition of receptor protein-tyrosine phosphatase-α by dimerization , 1996, Nature.

[33]  T. Mak,et al.  Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 , 1996, Nature.

[34]  D. Alexander,et al.  CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation , 1996, The Journal of experimental medicine.

[35]  M. Ogimoto,et al.  Selective Regulation of Lyn Tyrosine Kinase by CD45 in Immature B Cells (*) , 1995, The Journal of Biological Chemistry.

[36]  S. Stacker,et al.  Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease , 1995, Cell.

[37]  J. Cyster,et al.  Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. , 1995, Immunity.

[38]  T. Mak,et al.  Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice , 1993, Cell.

[39]  J. Schlessinger,et al.  Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase , 1993, Cell.

[40]  A. Weiss,et al.  CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. , 1993, The EMBO journal.

[41]  J. J. Wu,et al.  Evidence for monomeric and dimeric forms of CD45 associated with a 30-kDa phosphorylated protein. , 1992, The Journal of biological chemistry.

[42]  C. Goodnow,et al.  Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens , 1991, Nature.

[43]  J. Cambier,et al.  Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. , 1991, Science.

[44]  A. Weiss,et al.  Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway , 1990, Nature.

[45]  P. Johnson,et al.  Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Matthew L. Thomas,et al.  Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation , 1989, Cell.

[47]  S. Smith‐Gill,et al.  Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice , 1988, Nature.

[48]  R. Hardy,et al.  Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. , 1984, Proceedings of the National Academy of Sciences of the United States of America.