Neuroprotective effects of phytochemicals on dopaminergic neuron cultures

Abstract Introduction Parkinson's disease is a progressive neurodegenerative disorder characterised by a loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a significant decrease in dopamine levels and consequent functional motor impairment. Development Although its aetiology is not fully understood, several pathogenic mechanisms, including oxidative stress, have been proposed. Current therapeutic approaches are based on dopamine replacement drugs; these agents, however, are not able to stop or even slow disease progression. Novel therapeutic approaches aimed at acting on the pathways leading to neuronal dysfunction and death are under investigation. Conclusions In recent years, such natural molecules as polyphenols, alkaloids, and saponins have been shown to have a neuroprotective effect due to their antioxidant and anti-inflammatory properties. The aim of our review is to analyse the most relevant studies worldwide addressing the benefits of some phytochemicals used in in vitro models of Parkinson's disease.

[1]  Shang-Der Chen,et al.  Resveratrol Partially Prevents Rotenone-Induced Neurotoxicity in Dopaminergic SH-SY5Y Cells through Induction of Heme Oxygenase-1 Dependent Autophagy , 2014, International journal of molecular sciences.

[2]  Zhan-You Wang,et al.  Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. , 2010, Rejuvenation research.

[3]  Joo-Yong Lee,et al.  Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1 , 2013, Molecules and cells.

[4]  M. Oh,et al.  Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models , 2010, British Journal of Nutrition.

[5]  M. M. Maróstica Júnior,et al.  Polyphenols, antioxidants, and antimutagenic effects of Copaifera langsdorffii fruit. , 2016, Food chemistry.

[6]  R. Fricker,et al.  Calcitriol Imparts Neuroprotection In Vitro to Midbrain Dopaminergic Neurons by Upregulating GDNF Expression , 2013, PloS one.

[7]  M. Kwak,et al.  Protective effects of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-hydroxydopamine-induced neuronal cell death , 2007, Experimental & Molecular Medicine.

[8]  Z. Hong,et al.  Chiral HPLC determination and stereoselective pharmacokinetics of tetrahydroberberine enantiomers in rats. , 2012, Chirality.

[9]  Dong Jin Kim,et al.  A Novel Compound ITC-3 Activates the Nrf2 Signaling and Provides Neuroprotection in Parkinson’s Disease Models , 2015, Neurotoxicity Research.

[10]  M. Oh,et al.  Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. , 2012, Biological & pharmaceutical bulletin.

[11]  E. Hilario,et al.  Pretreatment with Resveratrol Prevents Neuronal Injury and Cognitive Deficits Induced by Perinatal Hypoxia-Ischemia in Rats , 2015, PloS one.

[12]  N. Vassallo,et al.  Tea Polyphenols in Parkinson's Disease. , 2015, Advances in experimental medicine and biology.

[13]  Xuechu Zhen,et al.  Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta , 2010, Neuropharmacology.

[14]  Z. Dong,et al.  Ginsenoside Rd Protects SH-SY5Y Cells against 1-Methyl-4-phenylpyridinium Induced Injury , 2015, International journal of molecular sciences.

[15]  O. Firuzi,et al.  Modulation of neurotrophic signaling pathways by polyphenols , 2015, Drug design, development and therapy.

[16]  Guan-Hong Li,et al.  Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation , 2007, Neuroscience Letters.

[17]  Jun Chen,et al.  Peroxiredoxin-2 Protects against 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration via Attenuation of the Apoptosis Signal-Regulating Kinase (ASK1) Signaling Cascade , 2011, The Journal of Neuroscience.

[18]  K. Krieglstein,et al.  IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP+-Induced Neurodegeneration , 2012, NeuroMolecular Medicine.

[19]  Na Chen,et al.  Resveratrol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats , 2011, Neurochemical Research.

[20]  Kun-Young Park,et al.  Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. , 2004, Journal of ethnopharmacology.

[21]  A. Varela-Echavarría,et al.  Recovery from experimental parkinsonism by semaphorin-guided axonal growth of grafted dopamine neurons. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

[22]  G. Barreto,et al.  Paullinia cupana Mart. var. Sorbilis protects human dopaminergic neuroblastoma SH-SY5Y cell line against rotenone-induced cytotoxicity , 2011, Human & experimental toxicology.

[23]  W. Rausch,et al.  Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture. , 2007, Journal of neural transmission. Supplementum.

[24]  K. Yung,et al.  Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture , 2009, Neurochemistry International.

[25]  M. Martinoli,et al.  Quercetin and Sesamin Protect Dopaminergic Cells from MPP+-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System , 2012, Oxidative medicine and cellular longevity.

[26]  J. Kim,et al.  Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages. , 2007, Journal of ethnopharmacology.

[27]  G. Le Douaron,et al.  Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease. , 2015, European journal of medicinal chemistry.

[28]  Sufen Yang,et al.  Curcumin Protects Dopaminergic Neuron Against LPS Induced Neurotoxicity in Primary Rat Neuron/Glia Culture , 2008, Neurochemical Research.

[29]  K. Lim,et al.  Mitochondrial dysfunction and Parkinson disease: a Parkin–AMPK alliance in neuroprotection , 2015, Annals of the New York Academy of Sciences.

[30]  Amaya Aleixandre,et al.  Los polifenoles, compuestos de origen natural con efectos saludables sobre el sistema cardiovascular , 2012 .

[31]  P. Tuchinda,et al.  Curcumin I Mediates Neuroprotective Effect Through Attenuation of Quinoprotein Formation, p‐p38 MAPK Expression, and Caspase‐3 Activation in 6‐Hydroxydopamine Treated SH‐SY5Y Cells , 2014, Phytotherapy research : PTR.

[32]  S. E. Park,et al.  Celastrol from ‘Thunder God Vine’ Protects SH-SY5Y Cells Through the Preservation of Mitochondrial Function and Inhibition of p38 MAPK in a Rotenone Model of Parkinson’s Disease , 2013, Neurochemical Research.

[33]  G. Sethi,et al.  Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. , 2011, Cancer letters.

[34]  M. Oh,et al.  Protective effects of Chunghyuldan against ROS-mediated neuronal cell death in models of Parkinson's disease. , 2010, Basic & clinical pharmacology & toxicology.

[35]  A. Deslandes,et al.  We need to move more: Neurobiological hypotheses of physical exercise as a treatment for Parkinson's disease. , 2015, Medical hypotheses.

[36]  J. Blesa,et al.  Oxidative stress and Parkinson’s disease , 2015, Front. Neuroanat..

[37]  J. Stock,et al.  Neuroprotective and Anti-inflammatory Properties of a Coffee Component in the MPTP Model of Parkinson’s Disease , 2013, Neurotherapeutics.

[38]  Tianhong Pan,et al.  Effects of green tea polyphenols on dopamine uptake and on MPP+ -induced dopamine neuron injury. , 2003, Life sciences.

[39]  C. Pérez,et al.  Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease. , 2013, ACS chemical neuroscience.

[40]  M. Martinoli,et al.  Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation , 2008, Journal of neuroscience research.

[41]  B. Aggarwal,et al.  Curcumin as "Curecumin": from kitchen to clinic. , 2008, Biochemical pharmacology.

[42]  Malcolm K Horne,et al.  Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. , 2005, Biochemical pharmacology.

[43]  D. Choi,et al.  Neuroprotective Effects of Vanillyl Alcohol in Gastrodia elata Blume Through Suppression of Oxidative Stress and Anti-Apoptotic Activity in Toxin-Induced Dopaminergic MN9D Cells , 2011, Molecules.

[44]  M. Oh,et al.  6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation , 2013, Acta Pharmacologica Sinica.

[45]  L. Hurley,et al.  Protective Effects of Curcumin Against Rotenone and Salsolinol-Induced Toxicity: Implications for Parkinson’s Disease , 2013, Neurotoxicity Research.

[46]  M. Miguel,et al.  [The polyphenols, naturally occurring compounds with beneficial effects on cardiovascular disease]. , 2012, Nutricion hospitalaria.

[47]  A. Akaike,et al.  Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. , 2007, Biochemical pharmacology.

[48]  Chunnuan Chen,et al.  Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson's disease , 2012, Neurobiology of Aging.

[49]  M. Martinoli,et al.  Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress , 2008, Oxidative medicine and cellular longevity.

[50]  Astragaloside IV prevents MPP+-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production , 2012, Molecular and Cellular Biochemistry.

[51]  J. Sousa,et al.  Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents. , 2016, Journal of ethnopharmacology.

[52]  W. Rausch,et al.  Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate , 2004, Brain Research.

[53]  G. Du,et al.  Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro , 2009, Pharmacology Biochemistry and Behavior.

[54]  W. Rausch,et al.  Protective effects of resveratrol on glutamate-induced damages in murine brain cultures , 2013, Journal of Neural Transmission.