论文信息 - Mammary carcinoma: toward a realistic mouse model of incurable cancers

Mammary carcinoma: toward a realistic mouse model of incurable cancers

ABSTRACT As long as breast cancer (BC) stays under immunosurveillance, it can be controlled by treatments eliciting anticancer immune responses. However, once BC escapes immunosurveillance, it becomes therapeutically uncontrollable. A paper in the Journal for ImmunoTherapy of Cancer describes a new hormone receptor-positive BC cell line generating incurable tumors in C57BL/6 mice.

C. López-Otín | M. Maiuri | G. Kroemer | María Pérez-Lanzón

[1] C. López-Otín,et al. New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma , 2023, Journal for ImmunoTherapy of Cancer.

[2] J. McQuade,et al. Bodywide ecological interventions on cancer , 2023, Nature Medicine.

[3] D. Hume,et al. Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer. , 2022, Cell reports.

[4] L. Zitvogel,et al. Immunogenic cell stress and death , 2022, Nature Immunology.

[5] Edoardo Pasolli,et al. Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment , 2021, Cell Death & Differentiation.

[6] Xueda Hu,et al. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells , 2021, Cell.

[7] O. Elemento,et al. Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer , 2020, Nature Communications.

[8] R. Schreiber,et al. Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion , 2011, Science.

[9] Lloyd J. Old,et al. Adaptive immunity maintains occult cancer in an equilibrium state , 2007, Nature.

[10] L. Galluzzi,et al. MPA/DMBA-driven mammary carcinomas. , 2021, Methods in cell biology.