Influences of age and mechanical stability on volume, microstructure, and mineralization of the fracture callus during bone healing: is osteoclast activity the key to age-related impaired healing?

[1]  G. Duda,et al.  Locally applied osteogenic predifferentiated progenitor cells are more effective than undifferentiated mesenchymal stem cells in the treatment of delayed bone healing. , 2009, Tissue engineering. Part A.

[2]  Thomas A Einhorn,et al.  Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function. , 2009, Bone.

[3]  G. Duda,et al.  A new animal model for bone atrophic nonunion: Fixation by external fixator , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[4]  G. Duda,et al.  Effect of Mechanical Stimulation on Osteoblast- and Osteoclast-Like Cells in vitro , 2008, Cells Tissues Organs.

[5]  Hicham Drissi,et al.  Reduced COX-2 Expression in Aged Mice Is Associated With Impaired Fracture Healing , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[6]  G. Duda,et al.  A new device to control mechanical environment in bone defect healing in rats. , 2008, Journal of biomechanics.

[7]  G. Duda,et al.  Influence of age and mechanical stability on bone defect healing: age reverses mechanical effects. , 2008, Bone.

[8]  R. Meyer,et al.  Genes with greater up‐regulation in the fracture callus of older rats with delayed healing , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[9]  C. Krettek,et al.  Effect of mechanical stability on fracture healing--an update. , 2007, Injury.

[10]  T. Keaveny,et al.  A biomechanical perspective on bone quality. , 2006, Bone.

[11]  W. R. Taylor,et al.  Impaired Angiogenesis, Early Callus Formation, and Late Stage Remodeling in Fracture Healing of Osteopontin‐Deficient Mice , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[12]  Thomas A. Einhorn,et al.  Fracture healing in the elderly patient , 2006, Experimental Gerontology.

[13]  N. Haas,et al.  Osteoclastic activity begins early and increases over the course of bone healing. , 2006, Bone.

[14]  Diane Hu,et al.  Cellular basis for age‐related changes in fracture repair , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[15]  G N Duda,et al.  The course of bone healing is influenced by the initial shear fixation stability , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  Georg N Duda,et al.  Initial vascularization and tissue differentiation are influenced by fixation stability , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[17]  N. Haas,et al.  Development and Characterization of a Standard Closed Tibial Fracture Model in the Rat , 2004, European Journal of Trauma.

[18]  L. Claes,et al.  The effect of mechanical stability on local vascularization and tissue differentiation in callus healing , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[19]  Mohit Bhandari,et al.  An economic evaluation of early versus delayed operative treatment in patients with closed tibial shaft fractures , 2002, Archives of Orthopaedic and Trauma Surgery.

[20]  John D. Currey,et al.  Bones: Structure and Mechanics , 2002 .

[21]  L. Phieffer,et al.  Delayed union of femoral fractures in older rats:decreased gene expression , 2001, BMC musculoskeletal disorders.

[22]  D. M. Banks,et al.  Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[23]  N. Haas.  Callusmodulation – Fiktion oder Realität? , 2000, Der Chirurg.

[24]  D Kaspar,et al.  Effects of Mechanical Factors on the Fracture Healing Process , 1998, Clinical orthopaedics and related research.

[25]  P. Lips,et al.  Response of normal and osteoporotic human bone cells to mechanical stress in vitro. , 1998, American journal of physiology. Endocrinology and metabolism.

[26]  L. Claes,et al.  Quantitative Assessment of Experimental Fracture Repair by Peripheral Computed Tomography , 1997, Calcified Tissue International.

[27]  P. Rüegsegger,et al.  A new method for the model‐independent assessment of thickness in three‐dimensional images , 1997 .

[28]  H. Gruber,et al.  Age‐related changes in osteogenic stem cells in mice , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  E. Chao,et al.  Noninvasive monitoring techniques for quantitative description of callus mineral content and mechanical properties. , 1993, Clinical orthopaedics and related research.

[30]  George Sanger,et al.  Structure and Mechanics , 1991 .

[31]  R. Brentani,et al.  Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections , 1979, The Histochemical Journal.

[32]  B. Nilsson,et al.  Age and fracture healing: a statistical analysis of 418 cases of tibial shaft fractures. , 1969, Geriatrics.

[33]  Movat Hz.  Demonstration of all connective tissue elements in a single section; pentachrome stains. , 1955 .

[34]  R. Shindell,et al.  Mineral and matrix contributions to rigidity in fracture healing. , 1990, Journal of biomechanics.

[35]  M. Ashby,et al.  Cellular solids: Structure & properties , 1988 .

[36]  E. Cronkite.  23 The Periosteum: Autoradiographic Studies on Cellular Proliferation and Transformation Utilizing Tritiated Thymidine , 1963, Clinical orthopaedics and related research.